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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
Although no published information on the aluminum, calcium or magnesium content of milk during maternal antacid therapy could be found, additional intake of these minerals by a nursing mother is unlikely to surpass that found in other infant foods. In addition, oral absorption of aluminum and magnesium is poor. Because of these factors, reviewers generally consider antacid use during breastfeeding to be acceptable.[1-3] No special precautions are required.
Drug Levels
Maternal Levels. The aluminum content of human milk is normally lower than cow's milk and much lower than infant formula.[4,5] Magnesium is a normal component of human milk.[6] When magnesium is administered intravenously in large doses, milk magnesium levels are increased only slightly.[7] Calcium is a normal component of human milk.[6] Alginic acid and simethicone, which are components of some antacids are not absorbed orally.[1,8]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Cimetidine, Famotidine, Nizatidine, Omeprazole, Pantoprazole, Sucralfate
References
- 1.
- Lewis JH, Weingold AB., Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912–23. [PubMed: 2864852]
- 2.
- Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: What are the safest therapy options? Drug Saf. 1998;19:325–37. [PubMed: 9804446]
- 3.
- Richter JE. Review article: The management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005;22:749–57. [PubMed: 16225482]
- 4.
- Fernández-Lorenzo JR, Cocho JA, Rey-Goldar ML, et al. Aluminum contents of human milk, cow's milk, and infant formulas. J Pediatr Gastroenterol Nutr. 1999;28:270–5. [PubMed: 10067727]
- 5.
- Mandić ML, Grgić J, Grgić Z, et al. Aluminum levels in human milk. Sci Total Environ. 1995;170:165–70. [PubMed: 7481740]
- 6.
- Neville MC. Calcium secretion into milk. J Mammary Gland Biol Neoplasia. 2005;10:119–28. [PubMed: 16025219]
- 7.
- Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982;143:685–8. [PubMed: 7091241]
- 8.
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998;14:259–62. [PubMed: 10205441]
Substance Identification
Substance Name
Antacids
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Antacid therapy--changes in mineral metabolism.[Scand J Gastroenterol Suppl. 1...]Review Antacid therapy--changes in mineral metabolism.Herzog P, Holtermüller KH. Scand J Gastroenterol Suppl. 1982; 75:56-62.
- Effect of metal-cation antacids on the pharmacokinetics of 1200 mg raltegravir.[J Pharm Pharmacol. 2016]Effect of metal-cation antacids on the pharmacokinetics of 1200 mg raltegravir.Krishna R, East L, Larson P, Valiathan C, Butterfield K, Teng Y, Hernandez-Illas M. J Pharm Pharmacol. 2016 Nov; 68(11):1359-1365. Epub 2016 Sep 27.
- [Effect of antacids on mineral metabolism].[Z Gastroenterol. 1983][Effect of antacids on mineral metabolism].Herzog P. Z Gastroenterol. 1983 Mar; 21 Suppl:117-26.
- Evaluation of buffering capacity and acid neutralizing-pH time profile of antacids.[J Formos Med Assoc. 1998]Evaluation of buffering capacity and acid neutralizing-pH time profile of antacids.Lin MS, Sun P, Yu HY. J Formos Med Assoc. 1998 Oct; 97(10):704-10.
- Review Effects of antacids on the clinical pharmacokinetics of drugs. An update.[Clin Pharmacokinet. 1990]Review Effects of antacids on the clinical pharmacokinetics of drugs. An update.Gugler R, Allgayer H. Clin Pharmacokinet. 1990 Mar; 18(3):210-9.
- Antacids - Drugs and Lactation Database (LactMed®)Antacids - Drugs and Lactation Database (LactMed®)
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