NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Amantadine

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 768-94-5

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Amantadine is a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1.
Correa N, Opler LA, Kay SR et al. Amantadine in the treatment of neuroendocrine side effects of neuroleptics. J Clin Psychopharmacol. 1987;7(2):91-5. [PubMed: 2884239]
2.
Siever LJ. The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients. J Clin Psychopharmacol. 1981;1(1):2-7. [PubMed: 6117579]

Substance Identification

Substance Name

Amantadine

CAS Registry Number

768-94-5

Drug Class

  • Breast Feeding
  • Anti-Infective Agents
  • Antiparkinson Agents
  • Antiviral Agents
  • Dopamine Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Ketamine[Drugs and Lactation Database (...]
    Review Ketamine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Cycloserine[Drugs and Lactation Database (...]
    Review Cycloserine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Cyclizine[Drugs and Lactation Database (...]
    Review Cyclizine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Trihexyphenidyl[Drugs and Lactation Database (...]
    Review Trihexyphenidyl
    . Drugs and Lactation Database (LactMed). 2006
  • Review Oxaprozin[Drugs and Lactation Database (...]
    Review Oxaprozin
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...