U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

Cover of Drugs and Lactation Database (LactMed®)

Drugs and Lactation Database (LactMed®) [Internet].

Show details


Last Revision: August 16, 2021.

Estimated reading time: 1 minute

CASRN: 155-09-9

image 134974261 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Because little information is available on the use of tranylcypromine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A woman with severe depression took tranylcypromine 100 to 120 mg daily, as well as pimozide, diazepam and alprazolam during pregnancy and postpartum. She breastfed her infant until about 2 weeks postpartum when the infant developed abdominal distension and feeding intolerance. The symptoms resolved on discontinuation of breastfeeding.[1]

Effects on Lactation and Breastmilk

Nine subjects were treated with an average dose of 29 mg daily (range 10 to 40 mg daily) of oral tranylcypromine for an average of 16 days. Serum prolactin levels increased by 3 mcg/L.[2]The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Nortriptyline, Paroxetine, Sertraline


Kennedy D, Webster WS, Hill M, et al. Abnormal pregnancy outcome associated with high-dose maternal tranylcypromine therapy: Case report and literature review. Reprod Toxicol. 2017;69:146–9. [PubMed: 28237611]
Price LH, Charney DS, Heninger GR. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients. Life Sci. 1985;37:809–18. [PubMed: 4033356]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antidepressive Agents

Monoamine Oxidase Inhibitors

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501173PMID: 30000232


Related information

Similar articles in PubMed

  • Review Isotretinoin.[Drugs and Lactation Database (...]
    Review Isotretinoin.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Triamterene.[Drugs and Lactation Database (...]
    Review Triamterene.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Dantrolene.[Drugs and Lactation Database (...]
    Review Dantrolene.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Droperidol.[Drugs and Lactation Database (...]
    Review Droperidol.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Tolazamide.[Drugs and Lactation Database (...]
    Review Tolazamide.
    . Drugs and Lactation Database (LactMed®). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...