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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Benzathine Penicillin G

Last Revision: November 16, 2020.

Estimated reading time: 1 minute

CASRN: 1538-09-6

image 134980183 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

: Limited information indicates benzathine penicillin G produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Benzathine penicillin G is acceptable in nursing mothers.

Drug Levels

Maternal Levels. Two women received one dose of 2.4 million units of benzathine penicillin G intramuscularly 20 hours after delivery. Milk concentrations decreased from 30 units/L on the third day to 10 units/L on the fifth day. After the fifth day, milk levels were undetectable. The authors estimated that an exclusively breastfed infant would receive a maximum of 6 to 7 units daily.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A breastfed 1-month-old infant with congenital syphilis developed a Herxheimer reaction 6 hours after its mother received 2.4 million units of benzathine penicillin G intramuscularly. However, the baby had also received 10 units of penicillin G at about the same time as the mother's injection. The reaction was possibly caused by penicillin in breastmilk.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Borderon E, Soutoul JH, Borderon JC, et al. Med Mal Infect. 1975;5:373–6. [Excretion of antibiotics in human milk]
2.
Rollier R, Rollier M, Bellouchi M. Bull Soc Fr Dermatol Syphiligr. 1967;74:178–80. [Herxheimer's reaction in maternal milk in early congenital syphilis] [PubMed: 6070262]

Substance Identification

Substance Name

Benzathine Penicillin G

CAS Registry Number

1538-09-6

Drug Class

Breast Feeding

Lactation

Anti-Infective Agents

Antibacterial Agents

Penicillins

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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