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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

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Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 92129-86-7

Drug Levels and Effects

Summary of Use during Lactation

There is no reason to withhold breastfeeding after tuberculosis skin testing or to avoid skin testing in nursing mothers.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

There is some evidence that breastfed infants can acquire immune responsiveness to tuberculin via breastmilk.[1][2][3] However, other investigators have found no evidence of breastmilk transfer of immunity.[4]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Martinez-Cairo Cueto S, Alasio-Chavez C, Davila Velasquez JR. [In vitro transfer of immunity against PPD with dialyzable extract of leukocytes from human colostrum]. Rev Alerg. 1992;39:126-32. [PubMed: 1492196]
Schlesinger JJ, Covelli HD. Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding. Lancet. 1977;2:529-32. [PubMed: 95733]
Masters PL. Maternal transmission of skin sensitivity to tuberculin. Lancet. 1982;2:276-7. [PubMed: 6124704]
Keller MA, Rodgriguez AL, Alvarez S et al. Transfer of tuberculin immunity from mother to infant. Pediatr Res.1987;22:277-81. [PubMed: 3658548]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Antigens
  • Purified Protein Derivative

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.


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