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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Bendroflumethiazide

Last Revision: February 7, 2019.

Estimated reading time: 1 minute

CASRN: 73-48-3

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the amount of bendroflumethiazide in breastmilk. Intense diuresis with large doses of bendroflumethiazide can decrease breastmilk production, especially during the neonatal period. Shorter-acting diuretics in low doses are preferred over bendroflumethiazide.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Bendroflumethiazide has been used to suppress lactation in oral doses of 5 mg twice daily for 5 days,[1] and in doses of 10 mg in the morning and 5 mg in the afternoon.[2] The added contribution of the diuretic to these measures, which are effective in suppressing lactation, has not been studied. There are no data on the effects of potent diuretics on established, ongoing lactation.

Alternate Drugs to Consider

Chlorothiazide, Hydrochlorothiazide

References

1.
Healy M. Suppressing lactation with oral diuretics. Lancet. 61;1:1353-4.
2.
Stout G. Suppression of lactation. Br Med J. 62;1:1150. Letter. PMC: PMC1958377.

Substance Identification

Substance Name

Bendroflumethiazide

CAS Registry Number

73-48-3

Drug Class

  • Breast Feeding
  • Antihypertensive Agents
  • Thiazide Diuretics

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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