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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 5591-45-7
Drug Levels and Effects
Summary of Use during Lactation
Because there is no published experience with thiothixene during breastfeeding, other antipsychotic agents are preferred.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Thiothixene has caused galactorrhea.[1] Hyperprolactinemia appears to be the cause of the galactorrhea.[2-4] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[5] [5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
References
- 1.
- Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry. 1979;136:1617–8. [Letter] [PubMed: 574364]
- 2.
- Turkington RW. Prolactin secretion in patients treated with various drugs: Phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349–54. [PubMed: 4560178]
- 3.
- Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62–6. [PubMed: 5061776]
- 4.
- Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279–86. [PubMed: 1259521]
- 5.
- Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63 Suppl 4:56–62. [PubMed: 11913677]
Substance Identification
Substance Name
Thiothixene
CAS Registry Number
5591-45-7
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Flupenthixol.[Drugs and Lactation Database (...]Review Flupenthixol.. Drugs and Lactation Database (LactMed®). 2006
- Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples.[J Pharm Sci. 1987]Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples.Severin G. J Pharm Sci. 1987 Mar; 76(3):231-4.
- Some clinical and physiologic effects of a thioxanthene derivative, thiothixene (P-4657B), in 20 newly hospitalized male schizophrenics.[J Clin Pharmacol J New Drugs. ...]Some clinical and physiologic effects of a thioxanthene derivative, thiothixene (P-4657B), in 20 newly hospitalized male schizophrenics.Hekimian LJ, Gershon S, Floyd A Jr. J Clin Pharmacol J New Drugs. 1967 Jan-Feb; 7(1):52-7.
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- Thiothixene - Drugs and Lactation Database (LactMed®)Thiothixene - Drugs and Lactation Database (LactMed®)
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