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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Piperacillin and Tazobactam

Last Revision: February 15, 2021.

Estimated reading time: 1 minute

CASRN: 157044-21-8

image 135079097 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Limited information indicates that piperacillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Tazobactam has not been studied in nursing mothers. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. No studies on the combination of piperacillin and tazobactam during breastfeeding have been reported. Piperacillin in a dosage of 4 grams intravenously every 8 hours for 3 or more days was given to 8 women. Milk levels were measured after 2 subsequent doses. After the first dose, milk levels ranged from 0.49 to 1.5 mg/L in the 3 hours after the dose. After the second dose, milk levels ranged from 1.1 to 1.9 mg/L in the 3 hours after the dose. Peak milk levels occurred 2 to 3 hours after the dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Baier R, Wolnik L, Puppel H, et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC 1982:203. Abstract 779.

Substance Identification

Substance Name

Piperacillin and Tazobactam

CAS Registry Number


Drug Class

Breast Feeding


Anti-Infective Agents

Antibacterial Agents


Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501068PMID: 30000127


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