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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Methyclothiazide

Last Revision: January 18, 2021.

Estimated reading time: 1 minute

CASRN: 135-07-9

image 134975247 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the amount of methyclothiazide in breastmilk. Intense diuresis with large doses may decrease breastmilk production. Other diuretics in low doses are preferred over methyclothiazide.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information on methyclothiazide was not found as of the revision date. Intense diuresis with thiazides and thiazide-like diuretics, fluid restriction and breast binding have been used to suppress postpartum lactation.[1-3] The added contribution of the diuretic to these measures, which are effective in suppressing lactation, has not been studied. There are no data on the effects of diuretics on established, ongoing lactation.

Alternate Drugs to Consider

Chlorothiazide, Hydrochlorothiazide

References

1.
Healy M. Suppressing lactation with oral diuretics. Lancet. 1961;277:1353–4.
2.
Reiher KH. Zentralbl Gynakol. 1963;85:188–90. [Suppression of lactation by stimulation of diuresis] [PubMed: 13973786]
3.
Stout G. Suppression of lactation. Br Med J 1962;1:1150. Letter. PMC1958377.

Substance Identification

Substance Name

Methyclothiazide

CAS Registry Number

135-07-9

Drug Class

Breast Feeding

Lactation

Antihypertensive Agents

Thiazide Diuretics

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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