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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 9005-49-6
Drug Levels and Effects
Summary of Use during Lactation
Although heparin itself has not been studied, low molecular weight heparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because heparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1,2]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Acenocoumarol, Dalteparin, Enoxaparin, Heparin, Rivaroxaban, Warfarin
References
- 1.
- Bates SM, Greer IA, Middeldorp S, et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e691S-736S. [PMC free article: PMC3278054] [PubMed: 22315276]
- 2.
- Bates SM, Rajasekhar A, Middeldorp S, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Venous thromboembolism in the context of pregnancy. Blood Adv 2018;2:3317-59. [PMC free article: PMC6258928] [PubMed: 30482767]
Substance Identification
Substance Name
Heparin
CAS Registry Number
9005-49-6
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Low molecular weight heparins and their clinical applications.[Prog Mol Biol Transl Sci. 2019]Review Low molecular weight heparins and their clinical applications.Hao C, Sun M, Wang H, Zhang L, Wang W. Prog Mol Biol Transl Sci. 2019; 163:21-39. Epub 2019 Mar 25.
- Review Polyethylene Glycol.[Drugs and Lactation Database (...]Review Polyethylene Glycol.. Drugs and Lactation Database (LactMed®). 2006
- Osteoblast growth inhibition by unfractionated heparin and by low molecular weight heparins: an in-vitro investigation.[Clin Appl Thromb Hemost. 2002]Osteoblast growth inhibition by unfractionated heparin and by low molecular weight heparins: an in-vitro investigation.Kock HJ, Handschin AE. Clin Appl Thromb Hemost. 2002 Jul; 8(3):251-5.
- Product individuality of commercially available low-molecular-weight heparins and their generic versions: therapeutic implications.[Clin Appl Thromb Hemost. 2006]Product individuality of commercially available low-molecular-weight heparins and their generic versions: therapeutic implications.Maddineni J, Walenga JM, Jeske WP, Hoppensteadt DA, Fareed J, Wahi R, Bick RL. Clin Appl Thromb Hemost. 2006 Jul; 12(3):267-76.
- The effects of three different low-molecular-weight heparins on blood loss after intramedullary nailing of trochanteric fractures.[Eur J Orthop Surg Traumatol. 2...]The effects of three different low-molecular-weight heparins on blood loss after intramedullary nailing of trochanteric fractures.Sivro M, Omerović Đ, Lazović F, Papović A. Eur J Orthop Surg Traumatol. 2023 Dec; 33(8):3631-3635. Epub 2023 May 31.
- Heparin - Drugs and Lactation Database (LactMed®)Heparin - Drugs and Lactation Database (LactMed®)
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