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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Linaclotide

Last Revision: September 20, 2021.

Estimated reading time: 1 minute

CASRN: 851199-59-2

image 135264508 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Linaclotide is minimally absorbed from the gastrointestinal tract and the drug and its active metabolite is not measurable in plasma following administration of recommended doses. Linaclotide would not be expected to enter the breastmilk or cause any adverse effects in breastfed infants. Linaclotide appears to be acceptable in nursing mothers and no special precautions are required.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date. However, the manufacturer reports that following oral administration of 72 mcg, 145 mcg, or 290 mcg of linaclotide once daily for 3 days to breastfeeding mothers taking linaclotide therapeutically, the concentrations of linaclotide and its metabolite were below the limits of quantitation (<0.25 mcg/L and <1 mcg/L, respectively) in all breast milk samples collected over 24 hours. No further details were provided.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Irritable Bowel Syndrome) Lubiprostone, Plecanatide, Polyethylene Glycol, Psyllium, Tenapanor

Substance Identification

Substance Name

Linaclotide

CAS Registry Number

851199-59-2

Drug Class

Breast Feeding

Lactation

Gastrointestinal Agents

Peptides

Guanylate Cyclase C Agonists

Laxatives

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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