NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Cladribine

Last Revision: June 3, 2019.

Estimated reading time: 1 minute

CASRN: 4291-63-8

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Because there is no published experience with cladribine during breastfeeding, it should be avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2] One group of authors recommends withholding breastfeeding for at 48 hours after a dose and longer in patients with impaired kidney function.[2] Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[4]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Multiple Sclerosis) Glatiramer, Immune Globulin, Interferon Beta, Methylprednisolone

References

1.
Cree BA. Update on reproductive safety of current and emerging disease-modifying therapies for multiple sclerosis. Mult Scler. 2013;19:835-43. [PubMed: 23319073]
2.
Almas S, Vance J, Baker T et al. Management of multiple sclerosis in the breastfeeding mother. Mult Scler Int. 2016;2016:6527458. [PMC free article: PMC4757692] [PubMed: 26966579]
3.
Urbaniak C, McMillan A, Angelini M et al. Effect of chemotherapy on the microbiota and metabolome of human milk, a case report. Microbiome. 2014;2:24. [PMC free article: PMC4109383] [PubMed: 25061513]
4.
Stopenski S, Aslam A, Zhang X et al. After chemotherapy treatment for maternal cancer during pregnancy, is breastfeeding possible? Breastfeed Med. 2017;12:91-7. [PubMed: 28170295]

Substance Identification

Substance Name

Cladribine

CAS Registry Number

4291-63-8

Drug Class

  • Breast Feeding
  • Antineoplastic Agents
  • Immunosuppressive Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site .

Views

Related information

Similar articles in PubMed

  • Review Gemcitabine[Drugs and Lactation Database (...]
    Review Gemcitabine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Azacitidine[Drugs and Lactation Database (...]
    Review Azacitidine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Bleomycin[Drugs and Lactation Database (...]
    Review Bleomycin
    . Drugs and Lactation Database (LactMed). 2006
  • Review Capecitabine[Drugs and Lactation Database (...]
    Review Capecitabine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Dacarbazine[Drugs and Lactation Database (...]
    Review Dacarbazine
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...