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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Lisuride

Last Revision: December 3, 2018.

Estimated reading time: 1 minute

CASRN: 18016-80-3

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Lisuride is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. It lowers serum prolactin and is approved in some countries for lactation suppression. Some experts recommend lisuride as a safer alternative to bromocriptine for lactation suppression, but others recommend avoiding all lactation suppressants.[1][2] Data are insufficient recommend one treatment for lactation suppression over another.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Lisuride suppresses serum prolactin increases in a dose-related fashion.[4][5] Comparative studies have found lisuride comparable in efficacy to bromocriptine, although rebound lactation occurred in more patients treated with lisuride 0.4 mg daily than in those treated with bromocriptine 5 mg daily.[6][7] Rebound lactation appears to be less with a higher dose of 0.6 mg daily and with 15 days of therapy rather than 10 days.[8][9]

Alternate Drugs to Consider

(Hyperprolactinemia) Bromocriptine, Cabergoline

References

1.
Marcellin L, Chantry AA. [Breast-feeding (part II): Lactation inhibition--Guidelines for clinical practice]. J Gynecol Obstet Biol Reprod (Paris). 2015;44:1080-3. [PubMed: 26527027]
2.
Anon. Do not use drugs to delay the onset of lactation. Relieve the discomfort and wait. Prescrire Int. 2012;32:918-20. [PubMed: 23951598]
3.
Oladapo OT, Fawole B. Treatments for suppression of lactation. Cochrane Database Syst Rev. 2012;9:CD005937. [PMC free article: PMC6599849] [PubMed: 22972088]
4.
Hardt W, Schmidt-Gollwitzer M, Horowski R. Suppression of lactation with lisuride. Gynecol Obstet Invest. 1979;10:95-105. [PubMed: 535777]
5.
De Cecco L, Venturine PL, Ragni N et al. Effect of lisuride on inhibition of lactation and serum prolactin. Br J Obstet Gynaecol. 1979;86:905-8. [PubMed: 508675]
6.
Bohnet HG, Kato K, De Moll H. Prolactin stimulation tests: Different response patterns after bromocriptine, lisuride, and metergoline treatment of puerperal women. Obstet Gynecol. 1988;71:53-5. [PubMed: 3336541]
7.
Van Dam LJ, Rolland R. Lactation-inhibiting and prolactin-lowering effect of lisuride and bromocriptine: A comparative study. Eur J Obstet Gynecol Reprod Biol. 1981;12:323-30. [PubMed: 7333409]
8.
Sereno Colo JA, Navarrete Horta MT. [Inhibition of lactation with lisuride. Clinical evaluation]. Ginecol Obstet Mex. 1994;62:31-4. [PubMed: 8168721]
9.
Strahl HJ, Goretzlehner G, Strahl S et al. [Lactation inhibition with various dosages of lisuride--prolactin secretion and effectiveness]. Zentralbl Gynakol. 1985;107:300-3. [PubMed: 4039514]

Substance Identification

Substance Name

Lisuride

CAS Registry Number

18016-80-3

Drug Class

  • Breast Feeding
  • Antiparkinson Agents
  • Dopamine Agonists
  • Serotonin Receptor Agonists

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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