NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Xenon

Last Revision: November 16, 2020.

Estimated reading time: 1 minute

CASRN: 7440-63-3

image 134988675 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Xenon is an inert gas that has ben used for general anesthesia. It was undetectable in breastmilk after extubation of the mothers. Breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse.[1] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure.

Drug Levels

Maternal Levels. Two mothers who underwent general anesthesia were given propofol and remifentanil as induction agents and rocuronium for intubation. After induction, propofol was stopped and xenon inhalation was used to maintain anesthesia for 57 and 59 minutes, respectively. Xenon was undetectable in breastmilk at 0 and 300 minutes after extubation in both mothers.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Four mothers who underwent general anesthesia were given propofol and remifentanil as induction agents and rocuronium for intubation. After induction, propofol was stopped and xenon inhalation was used to maintain anesthesia for between 57 and 70 minutes. Infants resumed breastfeeding from 1.5 to 5 hours after the end of surgery. None of the infants had noticeable symptoms of dizziness or drowsiness. All infants fared well at home after their mothers were discharged.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014;24:359–71. [PubMed: 24372776]
2.
Stuttmann R, Schafer C, Hilbert P, et al. The breast feeding mother and xenon anaesthesia: Four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol. 2010;10:1. [PMC free article: PMC2837001] [PubMed: 20167123]

Substance Identification

Substance Name

Xenon

CAS Registry Number

7440-63-3

Drug Class

Breast Feeding

Lactation

Anesthetics, Inhalation

Elements

Gases

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Nitrous Oxide[Drugs and Lactation Database (...]
    Review Nitrous Oxide
    . Drugs and Lactation Database (LactMed). 2006
  • Review Nitrogen, Liquid[Drugs and Lactation Database (...]
    Review Nitrogen, Liquid
    . Drugs and Lactation Database (LactMed). 2006
  • Review Fospropofol[Drugs and Lactation Database (...]
    Review Fospropofol
    . Drugs and Lactation Database (LactMed). 2006
  • Review Propofol[Drugs and Lactation Database (...]
    Review Propofol
    . Drugs and Lactation Database (LactMed). 2006
  • Review Enflurane[Drugs and Lactation Database (...]
    Review Enflurane
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...