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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Ethacrynic Acid

Last Revision: January 20, 2020.

Estimated reading time: 1 minute

CASRN: 58-54-8

image 134971799 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Because no information is available on the use of ethacrynic acid during breastfeeding and because intense diuresis might decrease lactation, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Low doses of ethacrynic acid may not suppress lactation.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Ethacrynic acid was reportedly used successfully to suppress lactation in 6 postpartum women who did not want to breastfeed and to decrease the intensity of milk production in another.[1] The added contribution of the diuretic to the other measures, which are effective in suppressing lactation, has not been studied. No data exist on the effects of loop diuretics on established, ongoing lactation.

Alternate Drugs to Consider

Chlorothiazide, Hydrochlorothiazide

References

1.
Mahon R, Dubecq J, Baudet E, et al. Bull Fed Soc Gynecol Obstet Lang Fr. 1968;20:440–2. [Use of Edecrine in obstetrics] [PubMed: 5759113]

Substance Identification

Substance Name

Ethacrynic Acid

CAS Registry Number

58-54-8

Drug Class

Breast Feeding

Lactation

Antihypertensive Agents

Loop Diuretics

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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