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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 70052-12-9
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that maternal intravenous eflornithine 400 mg/kg daily for 7 days does not cause any adverse serious effects in breastfed infants. Eflornithine is poorly absorbed after topical application, so it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
A cohort of 33 infants who were breastfed (extent not stated) by hospitalized mothers taking nifurtimox was followed in the Democratic Republic of the Congo. Thirty mothers took a full course of 30 doses of oral nifurtimox 15 mg/kg daily and all received 14 doses of intravenous eflornithine 400 mg/kg daily for 7 days for human African trypanosomiasis. (sleeping sickness). Nursing mothers also took a median of 4 other concomitant medications, including amoxicillin, ciprofloxacin, metronidazole, trimethoprim-sulfamethoxazole, aspirin, and diclofenac (1 patient each); hydrocortisone, promethazine and quinine (2 patients each); levamisole (6 patients); sulfadoxine-pyrimethamine (8 patients); dipyrone (13 patients); acetaminophen (16 patients); and mebendazole (17 patients). No serious adverse events were reported in any of the breastfed infants.[1,2]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Schmid C, Kuemmerle A, Blum J, et al. In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. PLoS Negl Trop Dis. 2012;6:e1920. [PMC free article: PMC3510081] [PubMed: 23209861]
- 2.
- Kuemmerle A, Schmid C, Kande V, et al. Prescription of concomitant medications in patients treated with nifurtimox eflornithine combination therapy (NECT) for T.b. gambiense second stage sleeping sickness in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2020;14:e0008028. [PMC free article: PMC7004379] [PubMed: 31986140]
Substance Identification
Substance Name
Eflornithine
CAS Registry Number
70052-12-9
Drug Class
Breast Feeding
Antiparasitic Agents
Antiprotozoal Agents
Enzyme Inhibitors
Trypanocidal Agents
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- Action of DL-alpha-difluoromethyl ornithine on Acanthamoeba culbertsoni.[Indian J Exp Biol. 1991]Action of DL-alpha-difluoromethyl ornithine on Acanthamoeba culbertsoni.Kishore P, Shukla OP. Indian J Exp Biol. 1991 Dec; 29(12):1134-9.
- Regulation of epidermal proliferation in mouse epidermis by combination of difluoromethyl ornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG).[J Invest Dermatol. 1985]Regulation of epidermal proliferation in mouse epidermis by combination of difluoromethyl ornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG).McCullough JL, Peckham P, Klein J, Weinstein GD, Jenkins JJ. J Invest Dermatol. 1985 Dec; 85(6):518-21.
- DL-alpha-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of DL-alpha-difluoromethylarginine to DL-alpha-difluoromethylornithine.[Biochem J. 1988]DL-alpha-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of DL-alpha-difluoromethylarginine to DL-alpha-difluoromethylornithine.Slocum RD, Bitonti AJ, McCann PP, Feirer RP. Biochem J. 1988 Oct 1; 255(1):197-202.
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