NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Alteplase

Last Revision: December 3, 2018.

Estimated reading time: 1 minute

CASRN: 105857-23-6

Drug Levels and Effects

Summary of Use during Lactation

Tissue plasminogen activator (tPA), which is identical to alteplase, is a normal component of human colostrum and breastmilk.[1][2][3] Levels in milk are highest in colostrum and decrease rapidly during the first week, followed by a sower decrease over time.[2][3] Because alteplase is a large protein molecule with a molecular weight of about 59,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. No information is available on the clinical use of alteplase during breastfeeding. Until more data become available, alteplase should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Heegaard CW, Larsen LB, Rasmussen LK, Hojberg KE, Petersen TE, Andreasen PA. Plasminogen activation system in human milk. J Pediatr Gastroenterol Nutr. 1997;25:159-66. [PubMed: 9252902]
2.
Ishii A, Yamada S, Yamada R, Hamada H. Determination of t-PA activity and t-PA antigen in human milk. J Perinat Med. 1992;20:203-7. [PubMed: 1453294]
3.
Marshall JM, Rees MC, Cederholm-Williams SA. Identification of t-PA as the major active plasminogen activator in human milk. Thromb Haemost. 1986;55:279-81. [PubMed: 3087004]

Substance Identification

Substance Name

Alteplase

CAS Registry Number

105857-23-6

Drug Class

  • Breast Feeding
  • Enzymes
  • Blood Coagulation Factors
  • Plasminogen Activators

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Ocrelizumab[Drugs and Lactation Database (...]
    Review Ocrelizumab
    . Drugs and Lactation Database (LactMed). 2006
  • Review Ofatumumab[Drugs and Lactation Database (...]
    Review Ofatumumab
    . Drugs and Lactation Database (LactMed). 2006
  • Review Natalizumab[Drugs and Lactation Database (...]
    Review Natalizumab
    . Drugs and Lactation Database (LactMed). 2006
  • Review Pertuzumab[Drugs and Lactation Database (...]
    Review Pertuzumab
    . Drugs and Lactation Database (LactMed). 2006
  • Review Factor Xa (recombinant), Inactivated[Drugs and Lactation Database (...]
    Review Factor Xa (recombinant), Inactivated
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...