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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 339086-32-7
Drug Levels and Effects
Summary of Use during Lactation
Crotalidae polyvalent immune Fab (Ovine) is used to treat crotalid envenomation (rattlesnakes, copperheads, cottonmouths, water moccasins). No information is available on the clinical use of Crotalidae polyvalent immune Fab during breastfeeding. Because it is a large protein molecule, the amount in milk is likely to be very low, and it is probably partially destroyed in the infant's gastrointestinal tract and very poorly absorbed by the infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Crotalidae Polyvalent Immune Fab (Ovine)
CAS Registry Number
339086-32-7
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Crotalidae Immune F(ab')2 (Equine)[Drugs and Lactation Database (...]Review Crotalidae Immune F(ab')2 (Equine). Drugs and Lactation Database (LactMed). 2006
- Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')<sub>2</sub> (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.[Clin Toxicol (Phila). 2022]Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')<sub>2</sub> (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.Spyres MB, Padilla GK, Gerkin RD, Hoyte CO, Wolk BJ, Ruha AM, ToxIC Snakebite Study Group.. Clin Toxicol (Phila). 2022 Jul; 60(7):838-842. Epub 2022 Mar 9.
- Use of both Fab and F(ab')<sub>2</sub> fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.[Am J Emerg Med. 2021]Use of both Fab and F(ab')<sub>2</sub> fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.Martin AM, Wang GS, Poel K. Am J Emerg Med. 2021 Jul; 45:677.e1-677.e3. Epub 2020 Nov 24.
- Review Crotalidae polyvalent immune Fab: in patients with North American crotaline envenomation.[BioDrugs. 2011]Review Crotalidae polyvalent immune Fab: in patients with North American crotaline envenomation.Keating GM. BioDrugs. 2011 Apr 1; 25(2):69-76.
- Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri).[Ann Emerg Med. 2002]Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri).Bush SP, Green SM, Moynihan JA, Hayes WK, Cardwell MD. Ann Emerg Med. 2002 Dec; 40(6):619-24.