≥2 ARMS/GROUPS: DICHOTOMOUS OUTCOMES (e.g. OR, RR, %death)

HPFS: adjusted for age, BMI, family history CRC, aspirin use, red meat consumption, physical activity; pack-years of smoking before age 30, alcohol consumption (5 out of 313 confirmed cancer case subjects were excluded for cancer from subsite analyses because of insufficient information on cancer location)

UI Author Year Outcome Exposure Categories(e.g., Tertiles)/Intervention Groups Mean Vit D level/dose Mean Ca level/dose No. of Cases (Event)* No. of Non- cases/Total N** Mean Follow-up, mo Crude or Adjusted analysis? Outcome Metric (e.g. OR, RR, HR, %) Outcome effect size CI ** P between groups*** P for trend****
11904316 Wu 2002 Primary adenocarcinoma (CRC) Cumulative average calcium intake (mg) ≤ 500 47 nd nd adjusted RR 1.00 nd 0.17
Cumulative average calcium intake (mg) 501– 600 48 nd nd adjusted RR 0.69 0.46– 1.04 nd
Cumulative average calcium intake (mg) 601– 700 58 nd nd adjusted RR 0.69 0.47– 1.01 nd
Cumulative average calcium intake (mg) 701– 800 51 nd nd adjusted RR 0.60 0.40– 0.90 nd
Cumulative average calcium intake (mg) 801– 100 81 nd nd adjusted RR 0.67 0.47– 0.97 nd
Cumulative average calcium intake (mg) 1001– 1250 84 nd nd adjusted RR 0.62 0.42– 0.92 nd
Cumulative average calcium intake (mg) >1250 60 nd nd adjusted RR 0.64 0.43– 0.95 nd
Proximal (right sided) colon cancer Cumulative average calcium intake (mg) ≤ 500 12 nd nd adjusted RR 1.00 nd 0.91
Cumulative average calcium intake (mg) 501– 600 15 nd nd adjusted RR 0.84 0.39– 1.81 nd
Cumulative average calcium intake (mg) 601– 700 19 nd nd adjusted RR 0.87 0.42– 1.79 nd
Cumulative average calcium intake (mg) 701– 800 22 nd nd adjusted RR 0.98 0.48– 1.99 nd
Cumulative average calcium intake (mg) 801– 100 34 nd nd adjusted RR 1.06 0.54– 2.07 nd
Cumulative average calcium intake (mg) 1001– 1250 24 nd nd adjusted RR 1.01 0.50– 2.05 nd
Cumulative average calcium intake (mg) >1250 24 nd nd adjusted RR 0.92 0.45– 1.87 nd
Distal (left sided) colon cancer Cumulative average calcium intake (mg) ≤ 500 22 nd nd adjusted RR 1.00 nd 0.12
Cumulative average calcium intake (mg) 501– 600 25 nd nd adjusted RR 0.77 0.43– 1.37 nd
Cumulative average calcium intake (mg) 601– 700 25 nd nd adjusted RR 0.64 0.36– 1.14 nd
Cumulative average calcium intake (mg) 701–800 16 nd nd adjusted RR 0.41 0.21–0.78 nd
Cumulative average calcium intake (mg) 801– 100 28 nd nd adjusted RR 0.51 0.29– 0.91 nd
Cumulative average calcium intake (mg) 1001– 1250 18 nd nd adjusted RR 0.46 0.24– 0.86 nd
Cumulative average calcium intake (mg) >1250 24 nd nd adjusted RR 0.58 0.32– 1.05 nd

From: Appendix C, Evidence Tables: R-Z

Cover of Vitamin D and Calcium
Vitamin D and Calcium: A Systematic Review of Health Outcomes.
Evidence Reports/Technology Assessments, No. 183.
Chung M, Balk EM, Brendel M, et al.

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