Adjuncts to the use of CTG – fetal blood sampling (predictive value of fetal acid base, fetal-maternal pH difference and fetal-maternal base deficit difference)

Bibliographic information Study type Evidence level Number of women and prevalence Women’s characteristics Type of test Reference standard Sensitivity, specificity, PPV and NPV Source of funding Additional comments
Khazin AF;Hon EH;Quilligan EJ; 1969 Oct 516Cohort studyIIN=194fetus in labourfetal blood samplingApgar scoreHigh Apgar score at 1 minutes and fetal base: r=-0.15 p<0.05

High Apgar score at 5 minutes and fetal base: r=-0.092 p<0.05

Low Apgar score at 1 minutes and fetal base: r=0.039 p>0.05

Low Apgar score at 5 minutes and fetal base: r=-0.32 p<0.05
Not stated
Khazin AF;Hon EH; 1971 517Cohort studyIIN=88women and fetus in labourfetal blood samplingfetal-maternal pH difference fetal-maternal base deficit differencefetal-maternal pH difference &
low Apgar score at 1 minute r=0.5503, p<0.005
high Apgar score at 1 minute r=0.0029, p>0.05
low Apgar score at 5 minute r=0.4959, p<0.05
low Apgar score at 5 minute r=-0.1282, p>0.05

fetal-maternal base deficit difference
low Apgar score at 1 minute r=-0.4274, p<0.05
high Apgar score at 1 minute r=-0.0093, p>0.05
low Apgar score at 5 minute r=-0.0647, p>0.05
low Apgar score at 5 minute r=-0.7313, p>0.05
not stated

From: Evidence tables

Cover of Intrapartum Care
Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth.
NICE Clinical Guidelines, No. 55.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Sep.
Copyright © 2007, National Collaborating Centre for Women’s and Children’s Health.

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