The research question is stated  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
The economic importance of the research question is stated  √  √  √  √  X  √  X  √  √  √  X  √  √  X  X  X  √  X  X  √  √ 
The view point(s) of the analysis are clearly stated and justified  X  √  √  X  X  √  X  √  √  √  X  √  √  X  √  X  X  X  X  X  X 
The rationale for choosing the alternative programmes or interventions compared is stated  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
The alternatives being compared are clearly described  √  √  √  √  P  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
The form of economic evaluation is stated  X  X  X  √  √  X  X  X  √  √  X  X  √  X  √  √  √  X  X  X  X 
The choice of form of economic evaluation is justified in relation to the questions addressed  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 

Data collection 

The source(s) of effectiveness estimates used are stated  √  √  U  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
Details of the design and results of effectiveness study are given (if based on single study)  √  √  NA  √  √  √  √  √  NA  NA  √  √  NA  √  √  √  √  √  √  √  √ 
Details of methods of synthesis or meta analysis of estimates are given (if based on an overview of a number of effectiveness studies)  NA  NA  U  NA  NA  NA  NA  NA  √  √  NA  NA  √  NA  NA  NA  NA  NA  NA  NA  NA 
The primary outcome measure(s) for the economic evaluation are clearly stated  √  √  NA  √  X  √  √  √  √  √  √  √  √  √  √  √  √  √  √  X  √ 
Methods to value health states and other benefits are stated  √  √  NA  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
Details of the subjects from whom valuations were obtained are given  √  √  NA  √  √  √  √  √  √  √  √  √  √  √  √  √  X  √  √  √  √ 
Productivity changes (if included) are reported separately  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA 
The relevance of productivity changes to the study question is discussed  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA  NA 
Quantities of resources are reported separately from their unit costs  X  √  √  √  X  √  √  X  X  √  √  √  X  √  √  √  X  X  X  X  √ 
Methods for the estimation of quantities and unit cost are described  √  √  U  √  U  √  X  √  √  √  √  √  √  P  √  X  √  X  X  X  √ 
Currency and price date are recorded  X  √  √  √  X  X  X  X  X  √  X  X  √  X  √  X  √  X  X  X  √ 
Details of currency of price adjustments for inflation or currency conversion are given  NA  NA  √  √  NA  NA  NA  NA  NA  NA  NA  √  NA  NA  NA  NA  NA  NA  NA  NA  NA 
Details of any model used are given  NA  NA  √  NA  NA  NA  NA  NA  √  √  NA  NA  √  NA  NA  NA  NA  NA  NA  NA  NA 
The choice of model used and the key parameters on which it is based are justified  NA  NA  U  NA  NA  NA  NA  NA  √  √  NA  NA  √  NA  NA  NA  NA  NA  NA  NA  NA 

Study number (refers to reference) 

Analysis and interpretation of results  1  2  3  4  5  6  7  8  9ab  10  11  12  13  14  15  16  17  18  19  20  21 

Time horizon of costs and benefits are stated  X  √  √  √  X  √  √  √  √  √  X  √  √  √  X  X  √  √  √  √  √ 
The discount rate(s) is stated  U  NA  NA  NA  NA  NA  NA  NA  NA  NA  U  NA  NA  NA  NA  U  NA  NA  NA  NA  NA 
The choice of rate(s) is justified  U  NA  NA  NA  NA  NA  NA  NA  NA  NA  U  NA  NA  NA  NA  U  NA  NA  NA  NA  NA 
An explanation is given if cost or benefits are not discounted  U  NA  NA  NA  NA  NA  NA  NA  NA  NA  U  NA  NA  NA  NA  U  NA  NA  NA  NA  NA 
Details of statistical tests and confidence intervals are given for stochastic data  X  √  √  √  √  P  P  P  X  X  P  √  X  P  √  X  P  √  P  √  √ 
The approach to sensitivity analysis is given  X  √  √  X  X  X  X  X  X  X  X  X  √  X  √  X  X  X  X  X  X 
The choice of variables for sensitivity analysis is justified  NA  √  √  NA  NA  NA  NA  NA  NA  NA  NA  NA  √  NA  √  NA  NA  NA  NA  NA  NA 
The ranges over which the variables are varied are stated  NA  √  √  NA  NA  NA  NA  NA  NA  NA  NA  NA  √  NA  √  NA  NA  NA  NA  NA  NA 
Relevant alternatives are compared  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
Incremental analysis is reported  NA  NA  √  X  NA  NA  NA  NA  X  X  NA  NA  √  NA  X  X  √  NA  NA  NA  NA 
Major outcomes are presented in a disaggregated as well as aggregated form  √  √  NA  √  X  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
The answer to the study question is given  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
Conclusions followed from the data reported  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √  √ 
Conclusions are accompanied by the appropriate caveats  P  √  P  P  X  √  P  √  X  X  P  P  √  √  √  X  √  P  P  P  √ 