Table 6.8Patient function

Patient function outcomeReferenceInterventionAssessment timeOutcome/effect size
Exercise vs control/other exercise
Aggregate locomotor function score; WOMAC function1 RCT (McCarthy et al. 2004) (N=214)Home + class-based exercise vs home-based exerciseOne year of follow-upFunction: p<0.001
WOMAC: p=0.014
Favours home + class exercise
Functionality (Lequesne Index); physical function1 RCT (Eyigor et al. 2004) (N=44)Progressive resistance exercise vs isokinetic exerciseStudy endpoint (6 weeks)NS
Social activity (AIMS2)1 RCT (Eyigor et al. 2004) (N=44)Progressive resistance exercise vs isokinetic exerciseStudy endpoint (6 weeks)p<0.05
Favours resistance exercise
AIMS2 items (self-care, mobility, walking, family support, level of tension, mood and household tasks) items; daily activities scores (Lequesne Index)1 RCT (Eyigor et al. 2004) (N=44)Progressive resistance exercise vs isokinetic exerciseStudy endpoint (6 weeks)NS
WOMAC physical function1 RCT (Lim 2002) (N=32)Open kinetic chain exercise vs closed kinetic chain exerciseStudy endpoint (6 weeks)NS
Risk of activities of daily living (ADL) disability (30-item questionnaire)1 RCT (Penninx et al. 2001) (N=250)Aerobic exercise vs attention control18 months follow-upCox proportional hazards: RR 0.53, %CI 0.33 to 0.85, p=0.009
Favours exercise
Risk of activities of daily living (ADL) disability (30-item questionnaire)1 RCT (Penninx et al. 2001) (N=250)Resistance exercise vs attention control18 months follow-upCox proportional hazards: RR 0.60, %CI 0.38 to 0.97, p=0.04
Favours exercise
Cumulative incidence of ADL disability1 RCT (Penninx et al. 2001) (N=250)Aerobic exercise vs resistance exercise18 months follow-upAerobic: 36.4%
Resistance: 37.8%
Both groups similar

From: 6, Non-pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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