Table 6.79Symptoms: stiffness

Stiffness outcomeReferenceInterventionAssessment timeOutcome/effect size
Glucosamine hydrochloride
WOMAC stiffness score, change from baseline1 RCT (Clegg et al. 2006) (N=1583)GH vs placebo24 weeks (end of treatment)NS
Mixed (knee or mixed or unspecified sites)
Glucosamine (general)
WOMAC stiffness1 MA (Towheed et al. 2005) 5 RCTs, N=538Glucosamine vs placeboTrial length: range 3 weeks to 3 years; follow-up: range immediate to 8 weeksNS

From: 6, Non-pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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