Table 18Sensitivity analysis on cardiovascular risks for COX-2 inhibitors

Incremental cost-effectiveness ratio (£ per QALY) *
Celecoxib 200 mg + PPIEtoricoxib 60 mg + PPI
Base-case analysis
Age 55, 3 months£9,499£25,836
Age 55, 2 years£10,183£27,242
Age 65, 3 months£10,173£67,559
Age 65, 2 years£10,349£46,374
Equal stroke risks for all Cox-2s (MEDAL)
Age 55, 3 months£54,046£38,110
Age 55, 2 years£49,640£36,736
Age 65, 3 months£443,694£161,480
Age 65, 2 years£71,013£61,105

Compared with the next best, non-dominated option: diclofenac 100 mg + PPI for age 55 base-case analysis; Ibuprofen 1200 mg + PPI for age 55 equal stroke risks analysis; no treatment for age 65.

From: Appendix D, Details of the NSAID/COX-2 inhibitor health economic model

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