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Continuing Education Activity

Citalopram hydrobromide is a selective serotonin reuptake inhibitor. The primary FDA-approved clinical use for citalopram hydrobromide is for treating depression in adults. Off-label uses include alcohol use disorder, coronary arteriosclerosis, obsessive-compulsive disorder, panic disorder, postmenopausal flushing, and premenstrual dysphoric disorder. Citalopram is listed in the WHO model list of essential medicines to treat depressive disorders. Citalopram hydrobromide exerts its antidepressant action by potentiating serotonergic activity in the central nervous system. Multiple studies confirmed that citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that has minimal effects on norepinephrine and dopamine neuronal reuptake. This activity reviews the indications, mechanism of action, administration, contraindications, monitoring, toxicity associated with citalopram, and the interprofessional team's role in caring for patients with conditions treated with citalopram.


  • Identify the FDA-approved and off-label indications for citalopram.
  • Apply evidence-based guidelines and recommendations when selecting citalopram as a treatment option.
  • Assess patients for potential adverse effects associated with citalopram.
  • Collaborate with mental health specialists, pharmacists, and other healthcare team members to optimize citalopram therapy and ensure the best outcomes with minimal adverse events.
Access free multiple choice questions on this topic.


Citalopram hydrobromide, the most selective serotonin reuptake inhibitor (SSRI), received FDA approval in 1998.[1] Citalopram is listed in the WHO model list of essential medicines to treat depressive disorders. According to the 2022 NICE (National Institute for Health and Care Excellence) guidelines, SSRIs should be considered the initial choice for pharmacotherapy in patients with depression.[2]

FDA-Approved Indication

  • Citalopram hydrobromide is for the treatment of depression in adults 18 years or older[3]
  • Recommendation: Adult, class IIa
  • Strength of evidence: Adult, category B

Off-Label Use

  • Obsessive-compulsive disorder (OCD)[4][5]
  • Panic disorder[6]
  • Generalized anxiety disorder (GAD)[7]
  • Social anxiety disorder (SAD)
  • Separation anxiety disorder
  • Premenstrual dysphoric disorder (PMDD)[8]
  • Binge eating disorder[9]
  • Posttraumatic stress disorder (PTSD)[10]
  • Premature ejaculation[11]
  • Poststroke depression[12]

The advantages and disadvantages of off-label use of this drug depend on the patient's condition and the clinician's judgment.

Mechanism of Action

Citalopram hydrobromide exerts its antidepressant action by potentiating serotonergic activity in the central nervous system (CNS). Multiple studies confirm that citalopram hydrobromide, an SSRI, has minimal effects on norepinephrine and dopamine neuronal reuptake.[13] The drug has a low affinity for muscarinic acetylcholine receptors and mild antagonist action on histamine but no significant effect on alpha- or beta-adrenergic receptors or dopamine-1, dopamine-2, gamma-aminobutyric acid, opioid, or benzodiazepine receptors.[14][15] Citalopram is a racemic mixture of both (R)- and (S)-enantiomers, whereas escitalopram consists solely of the (S)-enantiomer.[16]

The neurotrophic hypothesis of depression emphasizes that depression results from reduced brain-derived neurotrophic factor (BDNF), leading to neuronal loss and reduced hippocampal neurogenesis. Antidepressants elevate BDNF levels, counteracting neuronal and cellular loss. Extensive research in both preclinical and clinical depression studies reveals reduced serum BDNF levels in depressed individuals. Antidepressants, including citalopram, raise the expression of BDNF in the hippocampus and preferential cortex.[17]


  • The onset of action for depression is about 1 to 4 weeks. However, the complete response may take 8 to 12 weeks after treatment initiation.
  • Bioavailability is 80%. Tablets and oral solutions are bioequivalent.
  • Half-life is 24 to 48 hours (average, 35 hours). However, in patients with hepatic impairment, mild-to-moderate renal impairment, older age (60 or older), and those who are poor CYP2C19 metabolizers, the drug's half-life notably extends.
  • Citalopram is metabolized primarily by CYP450 3A4 and 2C19, and it exhibits weak inhibitory effects on CYP450 2D6.[18]


Citalopram is available in multiple oral dosage forms, including 10 mg, 20 mg, and 40 mg tablets taken once daily, as well as an oral solution with a concentration of 10 mg/5 mL. It is typically administered orally for adult patients younger than 60.

  • An initial dosage of 20 mg once daily (morning or evening, with or without food)
  • Increase the dosage to 40 mg daily after one week (maximum dosage of 40 mg daily)
  • The maximum dosage is 20 mg daily for patients older than 60 or those who are poor metabolizers of CYP2C19.

Patients who are at risk of experiencing significant adverse effects or overstimulation with citalopram should be started with the lowest recommended dosage. The dose should be increased gradually in 10-mg increments to optimize therapy. Anecdotal reports propose potential benefits of higher citalopram doses for individuals with OCD. Nevertheless, caution is advised, as dosages surpassing 40 mg daily are not recommended due to the associated risk of QT prolongation.[19][20][21]

Specific Population

Hepatic impairment: According to product labeling, the dosage needs to be reduced to 20 mg daily for patients with hepatic impairment.

Renal impairment: No dose adjustment is necessary for patients with mild-to-moderate renal impairment. Patients with severe renal impairments should be closely monitored for possible adverse reactions.

Pregnancy considerations: Citalopram is an FDA pregnancy category C drug. Citalopram is not an absolute contraindication in pregnancy but is not generally recommended, especially during the first trimester. Clinicians treating women with psychiatric conditions must inform the patient whether these medicines are needed during pregnancy.[22] Some reports associate SSRIs with persistent pulmonary hypertension of the newborn (PPHN).[23][24] Manufacturers report neonates exposed to SSRIs or SNRIs late in the third trimester have developed complications requiring respiratory support, tube feeding, and prolonged hospitalization.

Breastfeeding considerations: Based on the safety scoring system, citalopram is considered acceptable for use during breastfeeding. In cases where the mother used citalopram during pregnancy or other psychotropic drugs have proven ineffective, most experts typically advise against switching medications while breastfeeding. Drugs with lower excretion into breast milk are generally preferred, especially while nursing preterm infants or newborns. Breastfed newborns should be monitored for poor feeding, excess drowsiness, restlessness, agitation, and poor weight gain. Extra care should be exercised in a younger and exclusively breastfed infant when a breastfeeding woman is on psychotropic drugs.[25]

Pediatric patients: According to the package insert, the drug is not approved for use in pediatric patients, although clinicians may use it off-label for major depressive disorder, generalized anxiety disorder, and OCD.

Older patients: Citalopram has been listed in the Beers Criteria (American Geriatric Society) as a potentially inappropriate medicine. Caution should be used in patients aged 65 and older as it can cause or worsen hyponatremia or syndrome of inappropriate antidiuretic hormone secretion (SIADH).[26]

Adverse Effects

Reports suggest that adverse reactions occur in up to 10% of patients.[4][27][28]

Most Common Adverse Effects

  • CNS: Drowsiness, insomnia, dizziness, headache (dose-dependent)
  • Dermatologic: Diaphoresis
  • Gastrointestinal: Nausea, vomiting, xerostomia, constipation, diarrhea
  • Sexual: Ejaculation disorder (dose-dependent)[29]

Less Common Adverse Effects

  • Cardiovascular: Myocardial infarction, prolonged QT interval, Torsades de pointes
  • Hematologic: Hemorrhage, abnormal
  • Neurologic: Cerebrovascular accident
  • Psychiatric: Suicidal ideation, suicide, induction of mania[30]
  • Other: Serotonin syndrome [31]

Hyponatremia resulting from SIADH is a rare adverse effect. Citalopram has been shown to induce hyponatremia in case reports involving older patients. In addition to advanced age, other factors such as female gender, concurrent diuretic use, low body weight, and recent pneumonia may increase the likelihood of hyponatremia.

Evidence indicates a direct correlation between the dosage and the severity of adverse effects such as impotence, fatigue, somnolence, insomnia, sweating, and yawning.

Abrupt Discontinuation of Antidepressant

Antidepressant discontinuation syndrome commonly results when patients suddenly stop antidepressant therapy. The most common discontinuation syndrome symptoms include nausea, vomiting, diarrhea, headaches, light-headedness, dizziness, diminished appetite, sweating, chills, tremors, fatigue, somnolence, and sleep disturbances. Less common symptoms include electric shock-like sensations, cardiac arrhythmias, myalgia, arthralgia, and balance difficulties. Due to these adverse effects, gradual tapering of the antidepressant therapy over several weeks to several months (based on the treatment duration) is strongly recommended. The half-life of drugs and duration of the therapy should factor in these decisions, as antidepressants with a shorter half-life may need to be tapered more conservatively.

Boxed Warning

Citalopram hydrobromide is correlated with suicidality and worsening depression, especially in children, adolescents, and young adults (younger than 24). Antidepressants may elevate the risk of suicidal ideation in children, adolescents, and young adults when compared to placebo administration. The decision to use citalopram hydrobromide or any other antidepressant in children through young adults depends on the patient's specific condition and the clinician's judgment, weighing the potential benefits and risks on a case-by-case basis.[32]

Patients of any age who start antidepressant therapy should be monitored and observed closely for clinical deterioration, suicidality, or unusual behavior changes. Citalopram hydrobromide is not FDA-approved for use in pediatric patients.

Increased risk of suicidal ideation and treatment-emergent suicidal ideation (TESI) are concerns in younger patients at the onset of therapy. However, an analysis of 17 controlled clinical trials comprising 5000 patients who were treated with citalopram, a tricyclic antidepressant, another SSRI, or a placebo revealed that the citalopram group had the lowest incidence of suicide. Furthermore, family and twin studies offer evidence of a genetic influence on suicidal behavior, leading to the hypothesis that genetic factors may also contribute to TESI.

Drug-Drug Interactions

Citalopram has significant drug interactions, and clinicians should monitor patients closely. Limit the dosage of citalopram to a maximum of 20 mg per day if the patient is using bupropion, omeprazole, esomeprazole, cimetidine, fexinidazole, voriconazole, fluoxetine, fluvoxamine, or fluconazole. Citalopram is a substrate for CYP2C19, while fluconazole inhibits CYP2C19, potentially resulting in serotonin toxicity.[33]

SSRIs, including citalopram, may increase the risk of bleeding. SSRIs inhibit the serotonin transporter responsible for serotonin uptake into platelets. Consequently, SSRIs can deplete platelet serotonin, decreasing the ability to form clots and increasing the risk of bleeding. In addition, concurrent use of aspirin, NSAIDs, and warfarin increases the risk of bleeding.[34][35]


Citalopram is contraindicated with the concomitant use of monoamine oxidase inhibitors (MAOIs). Evidence suggests that concurrent use of citalopram alongside an MAOI can result in serotonin syndrome (serotonergic hyperactivity). Symptoms of serotonin syndrome include rigidity, hyperthermia, autonomic instability, mental status changes, and coma. Similar adverse reactions are possible in patients who abruptly switched from an SSRI to an MAOI; therefore, the recommendation is to wait 14 days after discontinuing citalopram to initiate an MAOI.[36]

Citalopram is also contraindicated in patients with hypersensitivity to the drug or excipient.[37] Secondary to its inhibitory effects on CYP 2D6, it could hypothetically increase thioridazine concentrations, inducing dangerous arrhythmias.[38] Canadian labeling for citalopram includes additional contraindications, specifically mentioning known QT interval prolongation or congenital long QT syndrome, which are not listed in the United States labeling.[39] Citalopram should not be administered in patients using urokinase, pimozide, methylene blue, linezolid, or dapoxetine. Linezolid is a reversible, nonselective monoamine oxidase inhibitor that can lead to serotonin syndrome if administered with serotonergic drugs.[40][41]


Before Treatment

  • Electrolytes, especially potassium and sodium, should be monitored and evaluated. Reevaluating electrolytes in patients at risk for electrolyte disturbances during the treatment is recommended.  
  • QT-prolongation should be monitored. ECG is necessary for patients with congenital long QT syndrome, bradycardia, hypokalemia or hypomagnesemia, recent acute myocardial infarction, uncompensated heart failure, or concomitant use of other QT-prolonging drugs.[42]

During Treatment

  • Patients need to be assessed and monitored for worsening depression, suicidality, or unusual changes in behavior during the initial few months of therapy or when the dose increases or decreases. Weekly face-to-face contact with patients during the initial first month of treatment, followed by visits every other week for the next month and ultimately at 3-month intervals, is recommended.
  • Weight and growth should be monitored regularly by a clinician during treatment in children and adolescents.
  • According to the Beers Criteria, monitor sodium levels closely when starting or adjusting the dose of citalopram in patients aged 65 and older.[26][26]

Psychiatric Assessment for Depression and Anxiety

  • Various scales in clinical practice can assist in screening anxiety disorder and depression and response to citalopram therapy.    
  • Patient Health Questionnaire (PHQ-9)[43]   
  • Montgomery-Asberg Depression Rating Scale(MADRS)[44]  
  • Hamilton Rating Scale for Depression(HDRS-17)[45] 
  • Generalized Anxiety Disorder 7 score (GAD-7)[46] 
  • Hamilton Anxiety Scale (HAM-A)[47]


Studies reveal that citalopram toxicity is not common, even at doses up to 100 mg. However, there is a chance of developing serotonin hyperactivity at therapeutic doses, primarily if using another serotonergic medication concomitantly. 

In the event of an intentional overdose, the ingestion of more than 600 mg of citalopram requires 8 hours of cardiac monitoring. At the end of the observation period, the patient can be discharged if the patient is asymptomatic and QTc is less than 450 milliseconds. However, continued inpatient cardiac monitoring is necessary for patients with QTc greater than 450 milliseconds at the end of the observation period.[48] Case reports also describe recurrent seizures associated with massive citalopram overdose. Seizures should be treated with benzodiazepines.[49]

Management of serotonin syndrome requires withdrawal of the citalopram and aggressive supportive treatment for hyperthermia and autonomic dysfunction. Cyproheptadine, a serotonin antagonist (5HT2 receptors), can be administered.[50]

Enhancing Healthcare Team Outcomes

Citalopram hydrobromide is a widely prescribed antidepressant by nurse practitioners, primary care providers, psychiatrists, internists, and neurologists. While the drug is effective for depression, its use requires monitoring. Prescribers should be careful as citalopram correlates with suicidality and worsening depression, especially in children, adolescents, and young adults (younger than 24 years old). Also, clinicians should monitor electrolytes and obtain an ECG before starting treatment because of the risk of prolonged QT syndrome. Nurses and pharmacists should counsel and educate patients not to combine the drug with alcohol, sedatives, and other antidepressants.

In an overdose, the rapid response team and the emergency clinician should rapidly stabilize the patient. Thus, an interprofessional approach that includes clinicians and pharmacists who operate as an integrated team with open communication is optimal for employing citalopram therapy, resulting in better patient outcomes with fewer adverse events. 

Review Questions


Lochmann D, Richardson T. Selective Serotonin Reuptake Inhibitors. Handb Exp Pharmacol. 2019;250:135-144. [PubMed: 30838457]
Kendrick T, Pilling S, Mavranezouli I, Megnin-Viggars O, Ruane C, Eadon H, Kapur N., Guideline Committee. Management of depression in adults: summary of updated NICE guidance. BMJ. 2022 Jul 20;378:o1557. [PubMed: 35858703]
Cipriani A, Purgato M, Furukawa TA, Trespidi C, Imperadore G, Signoretti A, Churchill R, Watanabe N, Barbui C. Citalopram versus other anti-depressive agents for depression. Cochrane Database Syst Rev. 2012 Jul 11;7(7):CD006534. [PMC free article: PMC4204633] [PubMed: 22786497]
Bezchlibnyk-Butler K, Aleksic I, Kennedy SH. Citalopram--a review of pharmacological and clinical effects. J Psychiatry Neurosci. 2000 May;25(3):241-54. [PMC free article: PMC1407724] [PubMed: 10863884]
Thomsen PH. Child and adolescent obsessive-compulsive disorder treated with citalopram: findings from an open trial of 23 cases. J Child Adolesc Psychopharmacol. 1997;7(3):157-66. [PubMed: 9466233]
Perna G, Bertani A, Caldirola D, Smeraldi E, Bellodi L. A comparison of citalopram and paroxetine in the treatment of panic disorder: a randomized, single-blind study. Pharmacopsychiatry. 2001 May;34(3):85-90. [PubMed: 11434404]
Varia I, Rauscher F. Treatment of generalized anxiety disorder with citalopram. Int Clin Psychopharmacol. 2002 May;17(3):103-7. [PubMed: 11981350]
Nevatte T, O'Brien PM, Bäckström T, Brown C, Dennerstein L, Endicott J, Epperson CN, Eriksson E, Freeman EW, Halbreich U, Ismail K, Panay N, Pearlstein T, Rapkin A, Reid R, Rubinow D, Schmidt P, Steiner M, Studd J, Sundström-Poromaa I, Yonkers K., Consensus Group of the International Society for Premenstrual Disorders. ISPMD consensus on the management of premenstrual disorders. Arch Womens Ment Health. 2013 Aug;16(4):279-91. [PMC free article: PMC3955202] [PubMed: 23624686]
McElroy SL, Hudson JI, Malhotra S, Welge JA, Nelson EB, Keck PE. Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial. J Clin Psychiatry. 2003 Jul;64(7):807-13. [PubMed: 12934982]
English BA, Jewell M, Jewell G, Ambrose S, Davis LL. Treatment of chronic posttraumatic stress disorder in combat veterans with citalopram: an open trial. J Clin Psychopharmacol. 2006 Feb;26(1):84-8. [PubMed: 16415713]
Saleh R, Majzoub A, Abu El-Hamd M. An update on the treatment of premature ejaculation: A systematic review. Arab J Urol. 2021;19(3):281-302. [PMC free article: PMC8451625] [PubMed: 34552780]
Towfighi A, Ovbiagele B, El Husseini N, Hackett ML, Jorge RE, Kissela BM, Mitchell PH, Skolarus LE, Whooley MA, Williams LS., American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 Feb;48(2):e30-e43. [PubMed: 27932603]
Luo Y, Chaimani A, Kataoka Y, Ostinelli EG, Ogawa Y, Cipriani A, Salanti G, Furukawa TA. Evidence synthesis, practice guidelines and real-world prescriptions of new generation antidepressants in the treatment of depression: a protocol for cumulative network meta-analyses and meta-epidemiological study. BMJ Open. 2018 Dec 09;8(12):e023222. [PMC free article: PMC6303574] [PubMed: 30530583]
Hyttel J. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):277-95. [PubMed: 6128769]
Baumann P. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. [PubMed: 8968657]
Edinoff AN, Akuly HA, Hanna TA, Ochoa CO, Patti SJ, Ghaffar YA, Kaye AD, Viswanath O, Urits I, Boyer AG, Cornett EM, Kaye AM. Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. Neurol Int. 2021 Aug 05;13(3):387-401. [PMC free article: PMC8395812] [PubMed: 34449705]
Chakrapani S, Eskander N, De Los Santos LA, Omisore BA, Mostafa JA. Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression. Cureus. 2020 Nov 09;12(11):e11396. [PMC free article: PMC7725195] [PubMed: 33312794]
Ji Y, Schaid DJ, Desta Z, Kubo M, Batzler AJ, Snyder K, Mushiroda T, Kamatani N, Ogburn E, Hall-Flavin D, Flockhart D, Nakamura Y, Mrazek DA, Weinshilboum RM. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol. 2014 Aug;78(2):373-83. [PMC free article: PMC4137829] [PubMed: 24528284]
Wagner E, Löhrs L, Siskind D, Honer WG, Falkai P, Hasan A. Clozapine augmentation strategies - a systematic meta-review of available evidence. Treatment options for clozapine resistance. J Psychopharmacol. 2019 Apr;33(4):423-435. [PubMed: 30696332]
Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Apr 18, 2022. Escitalopram. [PubMed: 30000334]
Alušík Š, Paluch Z. [Citalopram and QT prolongation]. Vnitr Lek. 2018 Winter;63(12):952-956. [PubMed: 29334745]
Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P., Danish Psychiatric Society. Danish Society of Obstetrics and Gynecology. Danish Paediatric Society. Danish Society of Clinical Pharmacology. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl. 2015;(445):1-28. [PubMed: 26344706]
Munk-Olsen T, Bergink V, Rommel AS, Momen N, Liu X. Association of Persistent Pulmonary Hypertension in Infants With the Timing and Type of Antidepressants In Utero. JAMA Netw Open. 2021 Dec 01;4(12):e2136639. [PMC free article: PMC8637253] [PubMed: 34851402]
Temming LA, Cahill AG, Riley LE. Clinical management of medications in pregnancy and lactation. Am J Obstet Gynecol. 2016 Jun;214(6):698-702. [PMC free article: PMC4884467] [PubMed: 26844758]
Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Sep 15, 2023. Citalopram. [PubMed: 30000244]
By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019 Apr;67(4):674-694. [PubMed: 30693946]
Hekmatjah J, Tareen K, Tareen RS. Citalopram-Associated Alopecia: A Case Report and Brief Literature Review. Curr Drug Saf. 2019;14(2):167-170. [PubMed: 30767750]
Aboukarr A, Giudice M. Interaction between Monoamine Oxidase B Inhibitors and Selective Serotonin Reuptake Inhibitors. Can J Hosp Pharm. 2018 May-Jun;71(3):196-207. [PMC free article: PMC6019085] [PubMed: 29955193]
Milne RJ, Goa KL. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991 Mar;41(3):450-77. [PubMed: 1711447]
Beckwith AR. The precipitation of mania by citalopram in a patient with interferon-induced depression. Psychosomatics. 2008 Jul-Aug;49(4):362-3. [PubMed: 18621943]
Schult RF, Morris AJ, Picard L, Wiegand TJ. Citalopram overdose and severe serotonin syndrome in an intermediate metabolizing patient. Am J Emerg Med. 2019 Oct;37(10):1993.e5-1993.e6. [PubMed: 31257122]
Rahikainen AL, Vauhkonen P, Pett H, Palo JU, Haukka J, Ojanperä I, Niemi M, Sajantila A. Completed suicides of citalopram users-the role of CYP genotypes and adverse drug interactions. Int J Legal Med. 2019 Mar;133(2):353-363. [PubMed: 30173302]
Levin TT, Cortes-Ladino A, Weiss M, Palomba ML. Life-threatening serotonin toxicity due to a citalopram-fluconazole drug interaction: case reports and discussion. Gen Hosp Psychiatry. 2008 Jul-Aug;30(4):372-7. [PubMed: 18585543]
Paton C, Ferrier IN. SSRIs and gastrointestinal bleeding. BMJ. 2005 Sep 10;331(7516):529-30. [PMC free article: PMC1200576] [PubMed: 16150746]
Zeiss R, Connemann BJ, Schönfeldt-Lecuona C, Gahr M. Risk of Bleeding Associated With Antidepressants: Impact of Causality Assessment and Competition Bias on Signal Detection. Front Psychiatry. 2021;12:727687. [PMC free article: PMC8566746] [PubMed: 34744821]
Ferguson JM. SSRI Antidepressant Medications: Adverse Effects and Tolerability. Prim Care Companion J Clin Psychiatry. 2001 Feb;3(1):22-27. [PMC free article: PMC181155] [PubMed: 15014625]
Herstowska M, Komorowska O, Cubała WJ, Jakuszkowiak-Wojten K, Gałuszko-Węgielnik M, Landowski J. Severe skin complications in patients treated with antidepressants: a literature review. Postepy Dermatol Alergol. 2014 May;31(2):92-7. [PMC free article: PMC4112250] [PubMed: 25097474]
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC. QTc prolongation, torsades de pointes, and psychotropic medications. Psychosomatics. 2013 Jan-Feb;54(1):1-13. [PubMed: 23295003]
Shah SR, Park K, Alweis R. Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence. Curr Probl Cardiol. 2019 Mar;44(3):92-106. [PubMed: 29784533]
Gatti M, Raschi E, De Ponti F. Serotonin syndrome by drug interactions with linezolid: clues from pharmacovigilance-pharmacokinetic/pharmacodynamic analysis. Eur J Clin Pharmacol. 2021 Feb;77(2):233-239. [PMC free article: PMC7803711] [PubMed: 32901348]
Alotaibi MS, Yousuf AZ, Khan A, Alshammari NS. Late Presentation of Linezolid-Induced Serotonin Syndrome After Maprotiline and Mirtazapine Therapy: A Case Report. 2021 Mar-Apr 01Clin Neuropharmacol. 44(2):71-74. [PubMed: 33443942]
Montgomery SA, Rasmussen JG, Lyby K, Connor P, Tanghøj P. Dose response relationship of citalopram 20 mg, citalopram 40 mg and placebo in the treatment of moderate and severe depression. Int Clin Psychopharmacol. 1992 Jun;6 Suppl 5:65-70. [PubMed: 1431024]
Ford J, Thomas F, Byng R, McCabe R. Use of the Patient Health Questionnaire (PHQ-9) in Practice: Interactions between patients and physicians. Qual Health Res. 2020 Nov;30(13):2146-2159. [PMC free article: PMC7549295] [PubMed: 32564676]
Hengartner MP, Jakobsen JC, Sørensen A, Plöderl M. Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trials. PLoS One. 2020;15(2):e0229381. [PMC free article: PMC7043778] [PubMed: 32101579]
Bobo WV, Angleró GC, Jenkins G, Hall-Flavin DK, Weinshilboum R, Biernacka JM. Validation of the 17-item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) data. Hum Psychopharmacol. 2016 May;31(3):185-92. [PMC free article: PMC5008690] [PubMed: 26999588]
Moore MT, Anderson NL, Barnes JM, Haigh EA, Fresco DM. Using the GAD-Q-IV to identify generalized anxiety disorder in psychiatric treatment seeking and primary care medical samples. J Anxiety Disord. 2014 Jan;28(1):25-30. [PubMed: 24334213]
Stein DJ, Khoo JP, Ahokas A, Jarema M, Van Ameringen M, Vavrusova L, Hӧschl C, Bauer M, Bitter I, Mosolov SN, Olivier V, Matharan S, Picarel-Blanchot F, de Bodinat C. 12-week double-blind randomized multicenter study of efficacy and safety of agomelatine (25-50 mg/day) versus escitalopram (10-20 mg/day) in out-patients with severe generalized anxiety disorder. Eur Neuropsychopharmacol. 2018 Aug;28(8):970-979. [PubMed: 30135032]
Macaluso M, Preskorn SH. Knowledge of the Pharmacology of Antidepressants and Antipsychotics Yields Results Comparable With Pharmacogenetic Testing. J Psychiatr Pract. 2018 Nov;24(6):416-419. [PubMed: 30395549]
Zoofaghari S, Wong A, Kiarasi P, Gheshlaghi F. Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations. J Res Pharm Pract. 2020 Jul-Sep;9(3):161-164. [PMC free article: PMC7808186] [PubMed: 33489987]
Iqbal MM, Basil MJ, Kaplan J, Iqbal MT. Overview of serotonin syndrome. Ann Clin Psychiatry. 2012 Nov;24(4):310-8. [PubMed: 23145389]

Disclosure: Nazila Sharbaf Shoar declares no relevant financial relationships with ineligible companies.

Disclosure: Kamron Fariba declares no relevant financial relationships with ineligible companies.

Disclosure: Ranjit Padhy declares no relevant financial relationships with ineligible companies.

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    Shrestha P, Fariba KA, Abdijadid S. StatPearls. 2024 Jan
  • Review Selective serotonin reuptake inhibitor exposure.[Top Companion Anim Med. 2013]
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    Fitzgerald KT, Bronstein AC. Top Companion Anim Med. 2013 Feb; 28(1):13-7.
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    Schwasinger-Schmidt TE, Macaluso M. Handb Exp Pharmacol. 2019; 250:325-355.
  • Review Citalopram: a comprehensive review.[Expert Opin Pharmacother. 2001]
    Review Citalopram: a comprehensive review.
    Pollock BG. Expert Opin Pharmacother. 2001 Apr; 2(4):681-98.
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