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Glycerol Phenylbutyrate (Ravicti) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr.
| Drug/Comparator | Strength | Dosage Form | Price ($) | Recommended Dose | Average Daily Drug Cost ($) | Average Annual Drug Cost ($) |
|---|---|---|---|---|---|---|
| Glycerol phenylbutyrate (Ravicti) | 1.1 g/mL | oral liquid | 48.000a /mL (43.6364a/g) | 4.5 to 11.2 mL:/m2/day (5 to 12.4 g/m2/day) in 3 to 6 equally divided doses, rounded up to the nearest 0.5 mL | $152.16 to $655.80b | $55,012 to $239,367 |
| Sodium phenylbutyrate (Pheburane) | 483 mg per gram of granules | granule | 19.2000c/g | Patient weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day Patient weight ≥ 20 kg: 9.9 g/m2/day to 13.0 g/m2/day | $82.92 to $382.62d | $29,853 to $137,743 |
| Sodium phenylbutyrate (Buphenyl) | 500 mg | tab powder | 48.7500e/g | Patients weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day Patient weight ≥ 20 kg:9.9 g/m2/day to 13.0 g/m2/day | $210.55 to $971.50d | $75,798 to $349,739 |
CDR = CADTH Common Drug Review.
Manufacturer’s submission.2
Based on average daily dose of 7.85 mL/m2 per day and body surface areas of 0.4 m2 (< 2 years old) and 1.72 m2 (≥ 18 years old).2
Association Québécoise des Pharmaciens Propriétaires (AQPP) Price List, based on manufacturer’s submission.2
Based on average daily dose of 530 mg/kg/day (patients weighing < 20kg) and 11.45g/m2/day (≥ 20 kg). Upper and lower bounds are based on the body surface area of the youngest patients (< 2 years old, 0.4m2) and the weight of the oldest patients (≥ 18 years old, 62.50 kg).2
Hyperion Therapeutics Inc. US WAC price, converted to Canadian dollars, from the manufacturer’s submission.2
From: APPENDIX 1, COST COMPARISON
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