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Glycerol Phenylbutyrate (Ravicti) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr.

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Glycerol Phenylbutyrate (Ravicti) [Internet].

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Table 7CDR Cost-Comparison Table

Drug/ComparatorStrengthDosage FormPrice ($)Recommended DoseAverage Daily Drug Cost ($)Average Annual Drug Cost ($)
Glycerol phenylbutyrate (Ravicti)1.1 g/mLoral liquid48.000a /mL (43.6364a/g)4.5 to 11.2 mL:/m2/day (5 to 12.4 g/m2/day) in 3 to 6 equally divided doses, rounded up to the nearest 0.5 mL$152.16 to $655.80b$55,012 to $239,367
Sodium phenylbutyrate (Pheburane)483 mg per gram of granulesgranule19.2000c/gPatient weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day
Patient weight ≥ 20 kg: 9.9 g/m2/day to 13.0 g/m2/day
$82.92 to $382.62d$29,853 to $137,743
Sodium phenylbutyrate (Buphenyl)500 mgtab powder48.7500e/gPatients weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day
Patient weight ≥ 20 kg:9.9 g/m2/day to 13.0 g/m2/day
$210.55 to $971.50d$75,798 to $349,739

CDR = CADTH Common Drug Review.


Manufacturer’s submission.2


Based on average daily dose of 7.85 mL/m2 per day and body surface areas of 0.4 m2 (< 2 years old) and 1.72 m2 (≥ 18 years old).2


Association Québécoise des Pharmaciens Propriétaires (AQPP) Price List, based on manufacturer’s submission.2


Based on average daily dose of 530 mg/kg/day (patients weighing < 20kg) and 11.45g/m2/day (≥ 20 kg). Upper and lower bounds are based on the body surface area of the youngest patients (< 2 years old, 0.4m2) and the weight of the oldest patients (≥ 18 years old, 62.50 kg).2


Hyperion Therapeutics Inc. US WAC price, converted to Canadian dollars, from the manufacturer’s submission.2


Copyright © CADTH 2017.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/


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