Table 48.1Cell Tropism of HHV-6A and HHV-6B

Cells Progeny virusb Virus tested Infected cells (%) References
HHV-6A HHV-6B
In vitro
astrocytes + + + (He et al., 1996)
epidermal cell line NT + (Yoshikawa et al., 2003a)
endothelial cells + + NT 1–38 (Caruso et al., 2003; Wu & Shanley, 1998)
CD34 positive stem cells NT + (Isomura et al., 2003)
immature thymocytes (Roffman and Frenkel, 1990)
mature thymocytes + + (Roffman and Frenkel, 1990)
thymocytes + anti-CD3 NT NT + (Roffman and Frenkel, 1991)
thymocytes + anti-CD3 + IL2 NT NT + (Roffman and Frenkel, 1991)
CBL + 5–77 (Black et al., 1989)
CBL + PHA + NT + (Black et al., 1989)
CBL + PHA + IL2 + NT + (Black et al., 1989)
CBMC + PHA NT NT + 5–6 (Kikuta et al., 1990a)
CBMC + anti-CD3 + IL2 NT NT + 50–90 (Kikuta et al., 1990a)
CBMC + PHA NT NT + 35–56 (Kikuta et al., 1990a)
PBMC NT NT (Kikuta et al., 1990a)
PBMC + anti-CD3 NT NT + 27–70 (Kikuta et al., 1990a)
PBMC + PHA NT NT (Kikuta et al., 1990a)
PBL 1 NT + 2–15 (Black et al., 1989; Frenkel et al., 1990)
PBL + PHA 5 NT + (Frenkel et al., 1990)
PBL + IL2 4 NT + (Frenkel et al., 1990)
PBL + IL2 + PHA 5 NT + (Frenkel et al., 1990)
CD28 positive T cells 0 NT + (Frenkel et al., 1990)
CD28 T cells + PHA 3 NT + (Frenkel et al., 1990)
CD28 T cells + IL2 1 NT + (Frenkel et al., 1990)
CD28 T cells + PHA + IL2 6 NT + (Frenkel et al., 1990)
tonsilar CD4+ T cells + + + (Grivel et al., 2003)
tonsilar CD8+ T cells + + + 5–20c (Grivel et al., 2003)
NK cells + NT (Lusso et al., 1993)
monocytes + + (Burd & Carrigan 1993)
macrophages
dendritic cells + + + 2 (Asada et al., 1999)
dendritic cells + + + >90 (Kakimoto et al., 2002)
dendritic cells + + + 30–95 (Hirata et al., 2001)
JJHAN cells + + >85 (Wyatt et al., 1990)
HSB-2 + + 28–90 (Ablashi et al., 1991; Wyatt et al., 1990)
Sup T1 + + >90 (Ablashi et al., 1991)
Molt-3 + + >90 (Ablashi et al., 1991)
MT-4 + NT + (Asada et al., 1989; Black et al., 1989)
MRC-5 fibroblast + + (Robert et al., 1996)
liver cell line + + + 50–90d (Cermelli et al., 1996)
mink lung epithelial cells + NT + (Simmons et al., 1992)
In vivo (ES patients)
ES patients
CD4+ T lymphocytes + + (Kondo et al., 2002a; Takahashi et al., 1989; Yasukawa et al., 1998)
CD8+ T lymphocytes + (Yasukawa et al., 1998)
Monocytes/macrophage + + 0.03–2 (Kondo et al., 2002a)
SCID-hu Thy/Liv mice
CD4+ T cell progenitors + + (Gobbi et al., 1999)
CD3+ cells + + + (Gobbi et al., 1999)
a

CBL (umbilical cord blood lymphocytes), CBMC (umbilical cord blood mononuclear cells),

PBL (peripheral blood lymphocytes), PBMC (peripheral blood mononuclear cells), NT (not tested)

b

log10 virus titer per ml of culture supernatant.

c

20% of tonsilar CD8+ T cells were infected with HHV-6A compared with 5% with HHV-6B viruses.

d

90% cells of a liver cell line were infected with HHV-6A, compared with 50% with HHV-6B viruses.

From: Chapter 48, HHV-6A, 6B, and 7: immunobiology and host response

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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