Table 2.1Sequenced herpesvirus genomes

Common name Straina Abbreviation Accession Size (bp)b Compositionc Reference
Common Formal G+C CG
Mammalian herpesvirus group d
Alphaherpesvirinae
Simplexvirus
Herpes simplex virus type 1 17 HSV-1 HHV-1 X14112 152261 68.3 1.01 McGeoch et al. (1988)
Herpes simplex virus type 2 HG52 HSV-2 HHV-2 Z86099 154746 70.4 1.06 Dolan et al. (1998)
B virus E2490 HVB CeHV-1 AF533768 156789 74.5 1.09 Perelygina et al. (2003)
SA8 B264 SA8 CeHV-2 AY714813 150715 76.0 1.09 Tyler et al. (2005)
Herpes papio 2 X313 HVP2 CeHV-16 DQ149153 156487 76.1 1.08 Tyler and Severini (2006)
Varicellovirus
Varicella-zoster virus Dumas VZV HHV-3 X04370 124884 46.0 1.14 Davison and Scott (1986)
Oka vaccine AB097932 125078 Gomi et al. (2002)
Oka parental AB097933 125125 Gomi et al. (2002)
MSP AY548170 124883 Grose et al. (2004)
BC AY548171 125459 Grose et al. (2004)
Varilrix DQ008354 124821 Vassilev (2005)
Varilrix DQ008355 124815 Vassilev (2005)
HJO AJ871403 124928 Fickenscher et al. (unpublished)
Simian varicella virus Delta SVV CeHV-9 AF275348 124138 40.4 1.12 Gray et al. (2001)
Bovine herpesvirus 1 [Cooper] BHV-1 BoHV-1 AJ004801 135301 72.4 1.19 Schwyzer & Ackermann (1996)
Bovine herpesvirus 5 SSV507/99 BHV-5 BoHV-5 AY261359 138390 74.9 1.17 Delhon et al. (2003)
Pseudorabies virus [Kaplan] PRV SuHV-1 BK001744 143461 73.6 1.12 Klupp et al. (2004)
Equine herpesvirus 1 Ab4 EHV-1 EHV-1 AY665713 150224 56.7 0.99 Telford et al. (1992)
V592 AY464052 149430 Nugent et al. (2006)
Equine herpesvirus 4 NS80567 EHV-4 EHV-4 AF030027 145597 50.5 0.93 Telford et al. (1998)
Mardivirus
Marek’s disease virus type 1 Md5 MDV-1 GaHV-2 AF243438 177874 44.1 1.01 Tulman et al. (2000)
GA AF147806 174077 Lee et al. (2000)
Md11 [AY510475] 170950 Niikura et al. (unpublished)
Marek’s disease virus type 2 HPRS24 MDV-2 GaHV-3 AB049735 164270 53.6 1.23 Izumiya et al. (2001)
Turkey herpesvirus FC126 HVT MeHV-1 AF291866 159160 47.6 1.11 Afonso et al. (2001)
Iltovirus
Infections laryngotracheitis virus [SA-2] ILTV GaHV-1 NC006623 148687 48.2 1.01 Thureen and Keeler (2006)
Psittacid herpesvirus 1e 97-0001 PsHV-1 PsHV-1 AY372243 163025 60.9 1.21 Thureen and Keeler (2006)
Betaherpesvirinae
Cytomegalovirus
Human cytomegalovirus Merlin HCMV HHV-5 AY446894 235645 57.5 1.19 Dolan et al. (2004)
AD169 X17403 229354 Chee et al. (1990)
AD169 BK000394 230287 Davison et al.(2003a)
AD169 [AC146999] [233739] Murphy et al. (2003b)
Towne [AY315197] [231236] Dunn et al. (2003)
Towne [AC146851] [229483] Murphy et al. (2003b)
Toledo [AC146905] [226889] Murphy et al. (2003b)
PH [AC146904] [229700] Murphy et al. (2003b)
TR [AC146906] [234881] Murphy et al. (2003b)
FIX [AC146907] [229209] Murphy et al. (2003b)
Chimpanzee cytomegalovirus CCMV PoHV-4 AF480884 241087 61.7 1.11 Davison et al. (2003a)
Rhesus cytomegalovirus 68-1 RhCMV CeHV-8 AY186194 221454 49.1 0.99 Hansen et al. (2003)
Unassigned
Tupaiid herpesvirus 2 THV TuHV-1 AF281817 195859 66.6 1.28 Bahr & Darai (2001)
Muromegalovirus
Murine cytomegalovirus Smith MCMV MuHV-1 U68299 230278 58.7 1.22 Rawlinson et al. (1996)
Rat cytomegalovirus Maastricht RCMV MuHV-2 AF232689 230138 61.0 1.25 Vink et al. (2000)
Roseolovirus
Human herpesvirus 6 U1102 HHV-6A HHV-6 X83413 159321 42.4 1.13 Gompels et al. (1995)
Z29 HHV-6B AF157706 162114 42.8 1.10 Dominguez et al. (1999)
HST AB021506 161573 Isegawa et al. (1999)
Human herpesvirus 7 JI HHV-7 HHV-7 U43400 144861 35.3 0.80 Nicholas (1996)
RK AF037218 153080 Megaw et al. (1998)
Gammaherpesvirinae
Lymphocryptovirus
Epstein–Barr virus [B95-8] EBV HHV-4 AJ507799 171823 59.5 0.61 de Jesus et al. (2003)
GD1 AY961628 171656 Zeng et al. (2005)
AG876 DQ279927 172764 Dolan et al. (2006)
B95-8 V01555 172281 Baer et al. (1984)
Marmoset lymphocryptovirus CJ0149 marmoset LCV CalHV-3 AF319782 149696 49.3 0.70 Rivailler et al. (2002a)
Rhesus lymphocryptovirus LCL8664 rhesus LCV CeHV-15 AY037858 171096 61.9 0.68 Rivailler et al. (2002b)
Rhadinovirus
Human herpesvirus 8 BC-1 HHV-8 HHV-8 U75698 [137508] 53.5 0.81
U75699 801 84.5 0.92 Russo et al. (1996)
U93872 [133661] Neipel et al. (1997)
Rhesus rhadinovirus 17577 RRV CeHV-17 AF083501 133719 52.2 1.11 Searles et al. (1999)
26-95 AF210726 130733 Alexander et al. (2000)
Murine herpesvirus 68f WUMS MHV-68 MuHV-4 U97553 119450 47.2 0.43 Virgin et al. (1997)
g2.4 AF105037 119550 Nash et al. (2001)
Bovine herpesvirus 4 66-p-347 BHV-4 BoHV-4 AF318573 108873 41.4 0.23 Zimmermann et al. (2001)
AF092919 2267 71.2 0.42
Herpesvirus ateles 73 HVA AtHV-3 AF083424 108409 36.6 0.40 Albrecht (2000)
AF126541 1582 77.1 0.79
Herpesvirus saimiri A11 HVS SaHV-2 X64346 112930 34.5 0.33 Albrecht et al. (1992)
K03361 1444 70.9 0.61
C488 AJ410493 113027 Ensser et al. (2003)
AJ410494 1458
Equine herpesvirus 2 86/67 EHV-2 EHV-2 U20824 184427 57.5 0.63 Telford et al. (1995)
Alcelaphine herpesvirus 1 C500 AHV-1 AlHV-1 AF005370 130608 46.2 0.42 Ensser et al. (1997)
AF005368 1113 72.0 0.69
Ovine herpesvirus 2 BJ1035 OvHV-2 OvHV-2 AY839756 135135 52.9 0.58 Stewart et al. (unpublished)
Fish herpesvirus group d
Undefined subfamily
Ictalurivirus
Channel catfish virus Auburn 1 CCV IcHV-1 M75136 134226 56.2 1.1 Davison (1992)
Bivalve herpesvirus group d
Undefined subfamily
Undefined genus
Ostreid herpesvirus 1 OHV OsHV-1 AY509253 207439 38.7 0.68 Davison et al. (2005)
a

Square brackets indicate the strain that was used most extensively in assembling a sequence combining data from several strains. A hyphen indicates that the strain was not specified.

b

Sizes were obtained from the latest version of the accessions, and may differ from those in the references through correction of errors. Square brackets indicate sequences that fall marginally short of full length: for MDV-1 and HCMV strains, sequences are for bacterial artificial chromosomes, the sizes representing a deleted form of the genome plus the vector; for HHV-8 strains, the sequence at the right end of the unique region was not determined. For members of subfamily Gammaherpesvirinae other than EHV-2, actual genome sizes are larger than those listed (approximately 150–180 kbp), owing to the presence of variable copy numbers of terminal repeats at both ends of the genome. Where a single value is given, this represents either the unique region flanked by partial terminal repeats or the unique region only. Where two values are given, the first is for the unique region and the second is for the terminal repeat.

c

G + C content is given as moles %, CG content is given as observed/expected frequency, taking into account overall nucleotide composition. Where multiple strains have been sequenced for a species, values are given for one strain only. For members of the Gammaherpesvirinae, values are given for the deposited sequences, which consist either of the unique region flanked by partial terminal repeat sequence, the unique region only, or separate accessions for the unique region and terminal repeat.

d

This taxon is used for the purposes of discussion, and, unlike the others in the Table, has no formal standing.

e

PsHV-1 is the closest relative of ILTV and is placed informally in this genus.

f

MHV-68 strains g2.4 and WUMS are essentially identical, since the latter was derived from the former.

From: Chapter 2, Comparative analysis of the genomes

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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