Fig. 27.1. The Epstein–Barr virus (EBV) genome.

Fig. 27.1

The Epstein–Barr virus (EBV) genome. (a) General organization of linear, EBV virion DNA. U1 and U2 are the short and long unique regions of the genome, respectively. These are interspersed with the four internal repeat regions IR1–4. TR represent the terminal repeats. The origin of replication (Ori-P) of the intracellular, circular, episomal form of the genome is indicated by the grey circle whilst the lytic origins of replication (Ori-lyt) are shown as black circles. (b) EcoRI and BamHI restriction endonuclease maps of EBV DNA and the positions of the genes expressed in latency. The BamHI fragments are named according to the well-established B95–8 designations with the exception of I (which is larger than its B95–8 counterpart), I′ and I″ (which are absent in the B95–8 strain). The splicing patterns of the latent RNAs through the coding regions are indicated. EBNA-LP is transcribed from variable numbers of repetitive exons. The full transcriptional patterns of the remaining EBNA genes are more complex than shown here (see text) and the BARTs consist of a number of differently spliced RNA species emanating from the same promoter (Smith et al., 2000; de Jesus et al., 2003). Note that the LMP2 proteins are produced from mRNAs that splice across the terminal repeats in the intracellular, circularised EBV genome. This region has often been referred to as Nhet to denote the heterogeneity in this region according to the number of terminal repeats within different virus isolates.

From: Chapter 27, EBV gene expression and regulation

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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