Table 54.7Current strength of evidence∗ for a causal role of KSHV infection in various diseases

Disease Strength of evidence
Kaposi’s sarcoma + + +
Primary effusion lymphoma + +
Multicentric Castleman’s disease + +
Hemophagocytic lymphohistiocytosis + +
Pulmonary hypertension +
Prostate cancer +
Amyotrophic lateral sclerosis +
Multiple myeloma

+ denotes weak evidence; + + denotes moderate evidence;


*+ + + denotes strong evidence;


− denotes that initial claims have been largely refuted.

From: Chapter 54, The epidemiology of KSHV and its association with malignant disease

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.