Fig. 56.4. KSHV infection of culture primary endothelial cells results in morphologic changes resembling spindling in vivo.

Fig. 56.4

KSHV infection of culture primary endothelial cells results in morphologic changes resembling spindling in vivo. Primary blood endothelial cells were mock infected(top) or infected with KSHV (botttom left); three weeks later, following spread of virus through the culture, the culture was 100% latently infected. Cells were then stained with phalloidin; note extensive spindling of the infected culture. Bottom right: cells were infected with KSHV and immediately carried in Phosphonofomate (PFA), an inhibitor of KSHV replication that blocks spread throught the culture; this blocks widespread establishment of latency and spindling.

From: Chapter 56, KSHV-induced oncogenesis

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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