Table 3Representative PHOSPHO1 inhibitors: SAR and selectivity

Structure/IDPubChem CIDPubChem SIDPHOSPHO1 IC50 (µM)PMM2 IC50(µM)PMI IC50 (µM)TNAP IC50 (µM)
Image ml086fu2.jpg

MLS-0390838
16749996 57287582 0.14 76.40 >100 >100
Image ml086fu3.jpg

MLS-0315803
4089709 56373872 0.81 5.17 0.71 >100
Image ml086fu4.jpg

MLS-0315794
2325813 56373857 1.07 62.8 8.58 >100
Image ml086fu5.jpg

MLS-0315861
25067463 56405542 0.82 12.2 4.93 >100
Image ml086fu6.jpg

MLS-0263839
5040456 56373499 0.50 13.2 2.79
Image ml086fu7.jpg

MLS-0315922
25181200 57287554 1.14 52.5 3.29 >100
Image ml086fu8.jpg

MLS-0315808
2467794 56373877 1.24 >100 23.6 >100
Image ml086fu9.jpg

MLS-0315805
2381612 56373874 0.56 >100 61.90 >100
Image ml086fu10.jpg

MLS-0390837
16749997 57287581 2.33 17.8 2.25 >100
Image ml086fu11.jpg

MLS-0022297
2327953 56373866 1.84 11.5 3.06 >100

From: The Role of PHOSPHO1 in the Initiation of Skeletal Calcification

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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