Table 3Criteria for identifying liabilities of tau active series

LiabilityReference Assay ActivityNumber of Series
Inconsistent activityInactive in ThT assay (AID 1460)199
Fluorescence/absorbanceChanges in total fluorescence in FP assay (AID-1463) spectroscopic profiling (AID-587, AID-591)151
Promiscuous aggregatorsCruzain activity +/− detergent (AID-1476, AID-1478)104
Low potency/efficacyFP assay (AID-1468)313
Low percentage of activesFP assay (AID-1468)108

From: High Throughput Screening for Small Molecule Inhibitors of Heparin-induced Tau Fibril Formation

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