Table 3Pharmacologic Properties of MLS-01014097, MLS-0107074

Cpd-IDAqueous Solubility (μg/mL) pH 5.0/6.2/7.4 (AID-1615)Permeability (×10−6 cm/s) pH 5.0/6.3/7.4 (AID-1557)Plasma Protein Binding (% Bound) (AID-1617)Plasma Stability (%Remaining) Human/Mouse (AID-1591/AID-1592)Microsomal Stability (%Remaining) Human/Mouse (AID-1555/pending)
Human (10μM/1μM)Mouse (10μM/1μM)
CID-665093

MLS-0014097
8.4/8.4/18.090/98/5898.6/98.787.9/89.5100.2/83.747.0/41.8
CID-2102207

MLS-0107074
0.3/0.3/0.998/91/75*99.9/99.199.7/99.382.4/77.517.0/1.8

From: Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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