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Helfand M, Peterson K. Drug Class Review: Triptans: Final Report Update 4 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Jun.

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Drug Class Review: Triptans: Final Report Update 4 [Internet].

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Appendix E. Pooled relative risks (95% confidence interval) for pain-free outcomes in placebo-controlled trials of early treatment with triptans

Triptan doseTriptan n/N (%)Placebo n/N (%)Relative risk (95% CI) NNTCochrane Q (degrees of freedom), P value
2-hour pain-free
Frovatriptan 2.5 mg67/241 (28%)48/241 (20%)1.40 (1.11, 1.76) NNT=12N/A
Almotriptan 12.5 mg110/265 (41%)64/262 (24%)1.71 (1.32, 2.21) NNT=60.67 (df=1) P=0.41
Rizatriptan 10 mg395/682 (60%)107/334 (31%)1.86 (1.57, 2.21) NNT=30.03 (df=1) P=0.86
Zolmitriptan 5 mg58/136 (43%)25/141 (18%)2.41 (1.81, 3.20) NNT=4N/A
Eletriptan 40 mg37/55 (68%)14/57 (25%)2.72 (1.92, 3.84) NNT=2N/A
 Treximet 85 mg/500 mg400/826 (48%)131/820 (16%)3.12 (2.64, 3.69) NNT=31.12 (df=3) P=0.77
 S-RT 100 mg94/142 (66%)30/153 (20%)3.38 (2.65, 4.30) NNT=2N/A
24-hour sustained pain-free
Almotriptan 12.5 mg87/265 (33%)42/262 (16%)2.08 (1.12, 3.86) NNT=63.49 (df=1) P=0.06
 Treximet 85 mg/500 mg313/826 (38%)92/820 (11%)3.21 (2.63, 3.91) NNT=41.18 (df=3) P=0.76
Eletriptan 40 mg34/55 (56%)10/57 (18%)3.21 (2.09, 4.94) NNT=3N/A
Rizatriptan 10 mg310/682 (45%)83/344 (24%)3.52 (1.67, 7.42) NNT=57.39 (df=1) P=0.01
 S-RT 100 mg57/142 (40%)15/153 (10%)4.09 (2.83, 5.92) NNT=3N/A
Copyright © 2009, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK47291

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