Table 7

Risk differences in healing of esophagitis in head-to-head trials of esomeprazole 40 mg compared with lansoprazole 30 mg

StudyDifference in healinga at 4 weeks (95% CI)Difference in healinga at 8 weeks (95% CI)
Castell 200244% (2 to 6)3% (1 to 5)
Fennerty 2005298% (2 to 14)4% (−1 to 10)
Howden 200218Not reported−2% (−9 to 5)
Pooled estimates
Random effects5% (1 to 9)3% (0 to 5)
Fixed effects 5% (2 to 7)
number needed to treat = 20
3% (1 to 5)
number needed to treat = 33
a

Difference in healing was calculated as the difference between the esomeprazole group and the lansoprazole group in the percent in which esophagitis was healed.

From: Results

Cover of Drug Class Review: Proton Pump Inhibitors
Drug Class Review: Proton Pump Inhibitors: Final Report Update 5 [Internet].
McDonagh MS, Carson S, Thakurta S.
Portland (OR): Oregon Health & Science University; 2009 May.
Copyright © 2009, Oregon Health & Science University, Portland, Oregon.

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