Table 4

Albuterol compared with levalbuterol: Demographic and study characteristics in adults (studies with effectiveness outcomes only)

Author YearStudy durationInterventionNMean age in years (SD)% FemaleOther medications permitted during studyQualityFunder
Hamilos 20076 to 12 monthsLevalbuterol metered dose inhaler 90 μg QID Albuterol metered dose inhaler 180 μg QID74639.0 (14.8)67Up to three 5- to10-day courses of oral steroidsPoorSepracor, Inc.
Nelson 1999
Pleskew 2004
4 weeksAlbuterol 1.25 mg
TID
Albuterol 2.5 mg
TID nebulizer
Levalbuterol 0.63 mg TID
nebulizer
Levalbuterol 1.25 mg TID nebulizer
36236.5 (15)60Medications for asthma or allergic rhinitis, including inhaled and intranasal corticosteroids, sodium cromoglycate and nedocromil sodium if withheld for a sufficient period before study visitsFairSepracor, Inc.
Nowak 20043 dosesAlbuterol 2.5 mg nebulizer
Albuterol 5.0 mg nebulizer
Levalbuterol 0.63 mg
Levalbuterol 1.25 mg
Levalbuterol 2.5 mg nebulizer

Levalbuterol 3.75 mg Levalbuterol 5.0 mg nebulizer
9133(12)54Medication restrictions: long-acting bronchodilators within 24 hours, ipratropium bromide and theophylline within 48 hours, astemizole within 7 days, and monoamine oxidase inhibitors, methylphenidate hydrochloride, and tricyclic antidepressants within 30 days.Fair (controlled clinical trial)Sepracor, Inc.
Nowak 200630 daysLevalbuterol 1.25 mg
Albuterol 2.5 mg
Drugs given every 20 min times 3, then every 40 min up to 3 doses, then as needed.
Discharged home on 5-day course of oral steroids and the study drug TID for 3 days then as needed up to TID for 7 days
62737.0 (13)61.2Oral prednisone 40 mg 1 doseFairSepracor, Inc.

Abbreviations: TID, three times a day; QID, four times a day.

From: Results

Cover of Drug Class Review: Quick-relief Medications for Asthma
Drug Class Review: Quick-relief Medications for Asthma: Final Report Update 1 [Internet].
Norris SL, McNally TK, Thakurta S.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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