NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Gartlehner G, Thieda P, Morgan LC, et al. Drug Class Review: Targeted Immune Modulators: Final Report Update 2 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Nov.

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Drug Class Review: Targeted Immune Modulators

Drug Class Review: Targeted Immune Modulators: Final Report Update 2 [Internet].

Show details

Appendix ICharacteristics of studies with poor internal validity

StudyDesignSample sizeInterventionReason for poor rating
Bathon et al., 2006285Pooled data analysis2402EtanerceptNon-systematic pooling
Bejarano et al., 286RCT148AdalimumabHigh LTF, high differential LTF
Carmona et al., 2007287Retrospective cohort5248VariousBias
Fleischmann et al., 2003288Pooled data analysis1128EtanerceptNon-systematic pooling
Gerloni et al.289Open label prospective trial24InfliximabHigh LTF
Menter et al., 2008290Retrospective data analysis1373InfliximabNon-systematic pooling
Moreland et al., 2006291Pooled retrospective analysis714EtanerceptHigh LTF; no ITT analysis
Sandborn et al., 2007149RCT662CertoluzimabHigh LTF
Schreiber et al., 2007150RCT428CertoluzimabHigh LTF
Seong et al., 2007292Retrospective data analysis193Infliximab and etanerceptInadequate design
Venkateshan, et al., 2009293Systematic review25 studiesVariousNo dual review; no critical appraisal or component studies
Wolfe et al., 2007294Retrospective data analysis17598Infliximab and etanerceptInadequate analysis of a case control study

ITT, intention to treat; LTF, loss to follow-up; RCT, randomized controlled trial.

Copyright © 2009, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK47216

Views

Other titles in this collection

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...