Table 4

Head-to-head comparison of eszopiclone compared with zolpidem on polysomnography-measured outcomes147

OutcomeMean (SD) at endpoint (P value compared with placebo)
1. Eszopiclone 2 mg
2. Eszopiclone 3 mg
3. Zolpidem 10 mg
4. Placebo
Eszopiclone 2 mg compared with zolpidem 10 mg, mean difference (95% CI)Eszopiclone 3 mg compared with zolpidem 10 mg, mean difference (95% CI)
Sleep latency1. 20.1 (17.6) min (P<0.0001)
2. 18.3 (19.6) min (P<0.0001)
3. 16.6 (14.4) min (P<0.0001)
4. 37.8 (31.1) min
1.70 min (−4.26 to 7.66)3.5 min (−2.10 to 6.74)
WASO1. 36.0 (25.0) min (P=0.1104)
2. 35.9 (31.7) min (P=0.0122)
3. 39.3 (28.5) min (P=0.3287)
4. 43.1 (32.5) min
−3.40 min (−13.84 to 7.04)−3.30 min (−12.62 to 6.02)
Number of awakenings1. 7.6 (4.5) times; (P=0.5983)
2. 6.5 (4.4) times; (P=0.0031)
3. 7.2 (4.3) times; (P=0.1838)
4. 7.7 (4.1) times
0.40 times (−1.13 to 1.93)−0.70 times (−1.23 to 0.92)

Abbreviations: SD, standard deviation; min, minutes; WASO, wake time after sleep onset.

From: Results

Cover of Drug Class Review: Newer Drugs for Insomnia
Drug Class Review: Newer Drugs for Insomnia: Final Report Update 2 [Internet].
Carson S, McDonagh MS, Thakurta S, et al.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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