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Peterson K, McDonagh M, Carson S, et al. Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Jan.

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Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet].

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Appendix F. Excluded studies

Original report

Exclusion codes 1: Foreign language, 2: Wrong outcome, 3: Wrong intervention, 4: Wrong population, 5: Wrong publication type, 6: Wrong study design, 8: Outdated systematic review

Excluded StudiesExclusion code #
Head-to-head trials
Adamo V, Aiello R, Altavilla G, et al. Ondansetron (OND) vs granisetron (GRA) in the control of chemotherapy-induced acute emesis. European Journal of Cancer. 1995;31Ÿ(Suppl 5):S256 Abs. 1225.5
Audhuy B, Cappelaeare P, Claverie N. Double-blind, comparative trial of the anti-emetic efficacy of two IV doses of dolasetron mesilate (DM) and granisetron (G) after infusion of high-dose cisplatin chemotherapy (CT). Eur-J-Cancer. 1995;31ƒ(Suppl 5):S253 Abs.1213.5
Audhuy B, Cappelaere P, Claverie N. Double-blind comparison of the antiemetic efficacy of two single IV doses of dolasetron and one IV dose of granisetron after cisplatin (80 mg/m2) chemotherapy. Supportive Care in Cancer. 1995;3(338):21.5
Beck T, Bryson J, Crawford K, McQuade B. Oral ondansetron (OND) for the prevention of nausea and vomiting (n&v) associated with cisplatin (CDDP) chemotherapy (CT). Ann-Oncol. 1998;9(Suppl 4):142.5
Bianchi A, Maccio A, Curreli L, Ghiani M, Santona MC, Astara G. Comparison of granisetron vs ondansetron vs tropisetron in the prophylaxis of acute nausea and vomiting induced by high-dose cisplatin for treatment of primary head and neck cancer: an open randomized controlled trial. Ann- Oncol. 1996;7(Suppl 5):135.5
Bonneterre J, Hecquet B, Fenaux I, et al. Granisetron (IV) compared with ondansetron (IV plus oral) in the prevention of nausea and vomiting induced by moderately-emetogenic chemotherapy. A cross-over study. Bulletin due Cancer. 1995;82(12):1038–1043.1
Brohee D, Mesina F. Comparison of dexamethasone (DXM) + granisetron (G) or + ondansetron (O) in cancer patients treated with moderately emetic cyctotoxics. European Journal of Cancer. 1995;31Ÿ(Suppl 5):S257 Abs.1231.5
Bubalo J, Seelig F, Karbowicz S, Maziarz RT. Randomized open-label trial of dolasetron for the control of nausea and vomiting associated with high-dose chemotherapy with hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2001;7(8):439–445.3
Cho JY, Park JO, Rha SY, Yoo NC, Kim JH, Roh JK. A comparative study of granisetron i.v. versus ondansetron i.v./oral in the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy. Ann-Oncol. 1996;7(Suppl 5):142.5
Del Favero A, Bergerat J, Chemaissani A, Dressler H. Single oral doses of dolasetron versus multiple doses of ondansetron in preventing emesis after 5 1995A;3(337):19.5
Fauser AA, Bergerat Cocquyt V, Chemaissani A, Del Favero A, Dressler HT. Double-blind, comparison trial of four single oral doses of dolasetron mesilate (DM) and multiple doses of ondansetron (OND) for emesis prevention after moderately emetogenic chemotherapy (CT). Eur-J-Cancer. 1995;31ƒ(Suppl 5):S254 Abs. 1217.5
Fumoleau P, Giovannini M, Rolland F, Votan B, Paillarse JM. Ondansetron suppository: An effective treatment for the prevention of emetic disorders induced by cisplatin-based chemotheraphy. Oral Oncology. 1997;33(5):354–358.6
Goode K, Laeder C. A comparison of the efficacy of intravenous granisetron and ondansetron in preventing postoperative vomiting in pediatric tonsillectomy and adenoidectomy procedures. Journal of the American Association of Nurse Anesthetists. 1997;65(4):385–386.5
Gralla RJ, Popovic W, et al. Can an oral antiemetic regimen be as effective as intravenous treatment against cisplatin: results of a 1054 patient randomized study of oral granisetron versus IV ondansetron. Proc Annu Meet Am Soc Clin Oncol. 1997.5
Huang XB, Hou M, Li H, et al. Randomized comparison of granisetron and ondansetron in the prevention of nausea and vomiting induced by cisplatin. West China Journal of Pharmaceutical Sciences. 2002;17(6):419–421.1
Huston CL, Sheridan CA, Ungard SD, et al. Comparison of oral granisetron, intravenous granisetron, and droperidol in the prevention of nausea and vomiting after outpatient laparoscopic procedures. Journal of the American Association of Nurse Anesthetists. 1996;64(5):437–438.5
Lacerda JF, Martins C, Carmo JA, et al. Randomized trial of ondansetron, granisetron, and tropisetron in the prevention of acute nausea and vomiting. Transplantation Proceedings. 2000;32(8):2680–2681.5
Lacerda JMF, Matrins C, Carmo JA, et al. Randomized trial of ondanestron (OND), granisetron (GRA) and tropisetron (TRO) in the prevention of acute nausea and vomiting in stem cell transplantation (SCT) [abstract]. Blood. 1999;94(10 Suppl 1):150a.5
Lofters WS, Zee B. Dolasetron (DOL) vs ondansetron (OND) with and without dexamethasone (DEX) in the prevention of nausea (N) and vomiting (V) in patients (PTS) receiving moderately emetogenic chemotherapy (MEC). The Symptom Control Commitee of the National Cancer Institute of Canada Clinical Trials Group and Nordic Merrel Dow Research Canada. Supportive Care in Cancer. 1995;3(338).5
Lofters WS, Zee B. Dolasetron (DOL) vs ondansetron (OND) with and without dexamethasone (DEX) in the prevention of nausea (N) and vomiting (V) in patients (pts) receiving moderately emetogenic chemotherapy (MEC). Eur-J-Cancer. 1995A;31?(Suppl 5):S252 Abs. 1205.5
Mabro M, Kerbrat P. Comparative trial of oral granisetron and intravenous ondansetron in patients receiving chemotherapy for breast cancer. Bulletin du Cancer. 1999;86(3):295–301.1
Mantovani G, Maccio A, Bianchi A, et al. Comparison of granisetron vs ondansetron vs tropisetron in the prophylaxis of acute nausea and vomiting induced by highly emetogenic chemotherapy (high-dose cisplatin) for treatment of primary head and neck cancer: an open cross-over randomized controlled trial. Eur-J-Cancer. 1995;31?(Suppl 5):S252 Abs. 1206.5
Massidda B, Ionta MT. Tropisetron vs granisetron vs ondansetron, all three in single i.v. bolus, in non-cisplatin acute and delayed emesis. A randomized study. Ann-Oncol. 1996;7(Suppl 1):141.5
Metaxari M, Petrou A, Zeaki M, Psaromichalaki M, Askitopoulou H. Prophylactic perioperative antiemesis in thyroid surgery: a randomised, double-blind comparison of granisetron, ondansetron and tropisetron [abstract]. Br J Anaesth. 1999;82(1):123.5
Muller D, Armbruster W, Unkel W, Apfel CC, Bornfeld N, Peters J. Blockade nozizeptiver ocularer Afferenzen durch Retrobulbaranasthesie vermindert nicht Ubelkeit und Erbrechen nach Propofol- Remifentanil-Anasthesie. [Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia]. Anasthesiol- Intensivmed-Notfallmed-Schmerzther. 2003;Anasthesiologie,- Intensivmedizin,-Notfallmedizin,-Schmerztherapie-AINS. 38(11):689–694.1
Roila F, De Angelis V, De Marinis F, et al. Ondansetron vs granisetron, both combined with dexamethasone in the prevention of cisplatin-induced emesis. The Italian Group for Antiemetic research. Supportive Care in Cancer. 1995;3(337).5
Scoponi CA, Torresi U, Di Giuseppe M, Giustozzi M. Are 5-HT3 antagonists a standard antiemetic treatment also in slightly and moderately emetogenic regimens? Oncologia. 1998;21(9):40–44.1
Spina M, Valentini M, Fedele P, et al. Randomized comparison of granisetron vs ondansetron in patients (PTS) with. Supportive Care in Cancer. 1995;3(343):38.5
Spina M, Valentini M, Fedele P, et al. Randomized comparison of granisetron vs ondansetron in patients (pts) with HIV-related non-Hodgkin's lymphoma (HIV-NHL) receiving moderately emetogenic chemotherapy (CT) regimens [abstract]. Proceedings of the American Society of Clinical Oncology. 1995;14(532).5
Stewart L, Crawford SM. A double-blind randomised trial of Granisetron + Dexamethasone (Dex) v Odansetrin-Dex in the treatment of cisplatin associated nausea and vomiting. British Journal of Cancer. 1996;73(Handsearch Br-J-Cancer Suppl XXVI):51.5
Tsavaris N, Kosmas C, Samarkos M, et al. Randomized comparative study of antiemetic activity of metoclopramide (M) vs ondansetron (Od) vs tropisetron vs granisetron (G) in patients receiving moderately emetogenic chemotherapy. Supportive Care in Cancer. 1996;4(252):114.5
Van Belle S, Hesketh PJ, Eldridge K, Carides A, Horgan K. An NK1 antagonist versus a 5-HT3 antagonist in patients receiving high dose cisplatin: comparison of the time course of acute emesis provides a rationale for combination therapy. Eur-J-Cancer. 2001;37(Suppl 6):362 Abs. 1349.5
Yelken BB, Gulec S, Hedbe L, Ekemen S, Tanriverdi B. Comparison of Ondansetron, Tropisetron, Granisetron and Droperidol for prevention of PONV after gyneocological laparoscopy in patients receiving TIVA with Remifentanyl and Propofol. Turk Anesteziyoloji Ve Reanimasyon Dernegi Dergisi. 2003;31(4):189–194.1
Active control trials
On the relationship between nausea and vomiting in patients undergoing chemotherapy. Italian Group for Antiemetic Research. Support Care Cancer. May 1994;2(3):171–176."2
Aapro MS, Thuerlimann B, Sessa C, de Pree C, Bernhard J, Maibach R. A randomized double-blind trial to compare the clinical efficacy of granisetron with metoclopramide, both combined with dexamethasone in the prophylaxis of chemotherapy-induced delayed emesis. Annals of Oncology. 2003;14(2):291–297.2
Abou Zeid H, Al-Gahamdi A, Abdul-Hadi M. Dolasetron decreases postoperative nausea and vomiting after breast surgery. Breast Journal. 2002;8(4):216–221.2
Adducci E, Gorgoglione M, Aceto P, et al. The prophylaxis of postoperative nausea and vomiting after laparoscopic cholecystectomy. Acta Medica Romana. 2002;40(4):331–339.2
Advani SH, Gopal R, Dhar AK, Lal HM, Cooverji ND. Comparative evaluation of the clinical efficacy and safety of ondansetron and metoclopramide in the prophylaxis of emesis induced by cancer chemotherapy regimens including cisplatin. Journal of the Association of Physicians of India. 1996;44(2):127- 130.2
Agarwal A, Bose N, Gaur A, Singh U, Gupta MK, Singh D. Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy. Canadian Journal of Anesthesia. 2002;49(6):554–560.2
Ahmed AB, Hobbs GJ, Curran JP. Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery. British Journal of Anaesthesia. 2000;85(5):678–682.2
Ahn MJ, Lee JS, Lee KH, Suh C, Choi SS, Kim SH. A randomized double- blind trial of ondansetron alone versus in combination with dexamethasone versus in combination with dexamethasone and lorazepam in the prevention of emesis due to cisplatin-based chemotherapy. American Journal of Clinical Oncology. 1994;17(2):150–156.2
Aksoylar S, Akman SA, Ozgenc F, Kansoy S. Comparison of tropisetron and granisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapy. Pediatric Hematology and Oncology. 2001;18(6):397–406.2
Alexander R, Fennelly M. Comparison of ondansetron, metoclopramide and placebo as premedicants to reduce nausea and vomiting after major surgery. Anaesthesia. 1997;52(7):695–698.2
Alexander R, Lovell AT, Seingry D, Jones RM. Comparison of ondansetron and droperidol in reducing postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia. 1995;50(12):1086–1088.2
Alfieri AB, Cubeddu LX. Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients. British Journal of Cancer. 1995;72(4):1013–1015.2
Alkaissi A, Gunnarsson H, Johnsson V, Evertsson K, Ofenbartl L, Kalman S. Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting. Acta Anaesthesiologica Scandinavica. 2004;48(6):761–771.2
Alon E, Himmelseher S. Ondansetron in the treatment of postoperative vomiting: A randomized, double-blind comparison with droperidol and metoclopramide. Anesthesia and Analgesia. 1992;75(4):561–565.2
An TT, Liu XY, Fang J, Wu MN. Randomized trial to compare the effect of ondansetron versus metopromide plus dexamethasone in controlling delayed emesis after high-dose cisplatin. Chinese Journal of Clinical Oncology. 2002;29(8):560–562.2
Anonymous. Persistence of efficacy of three antiemetic regimens and prognostic factors in patients undergoing moderately emetogenic chemotherapy. Italian Group for Antiemetic Research. Journal of Clinical Oncology. 1995;13(9):2417–2426.2
Anonymous. Delayed emesis induced by moderately emetogenic chemotherapy: do we need to treat all patients? The Italian Group for Antiemetic Research. Annals of Oncology. 1997;8(6):561–567.2
Anonymous. Ondansetron versus metoclopramide, both combined with dexamethasone, in the prevention of cisplatin-induced delayed emesis. The Italian Group for Antiemetic Research. Journal of Clinical Oncology. 1997;15(1):124–130.2
Apfel CC, Korttila K, Abdalla M, et al. An international multicenter protocol to assess the single and combined benefits of antiemetic interventions in a controlled clinical trial of a 2x2x2x2x2x2 factorial design (IMPACT). Controlled Clinical Trials. 2003;24(6):736–751.2
Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. New England Journal of Medicine. 2004;350(24):2441–2451.2
Arechevala E, Aulitzky W, Boeckmann W, Butcher ME, Dearnaley DP, Droz JP. A randomised, double-blind comparative study of ondansetron (OND) plus dexamethasone (DEX) with metoclopramide (MCP) plus dex as anti- emetic prophylaxis during multi-day cisplatin chemotherapy. Ann-Oncol. 1992;3(Suppl 5):183.2
Argiriadou H, Papaziogas B, Pavlidis T, et al. Tropisetron vs ondansetron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: A randomized double-blind, placebo-controlled study. Surgical Endoscopy. 2002;16(7):1087–1090.2
Ascaso FJ, Ayala I, Carbonell P, Castro FJ, Palomar A. Prophylactic intravenous ondansetron in patients undergoing cataract extraction under general anesthesia. Ophthalmologica. 1997;211(5):292–295.2
Badaoui R, Pouilly A, Yagoubi A, Carpentier F, Riboulot M, Ossart M. Comparison of ondansetron and droperidol in the prevention of postoperative nausea and vomiting. Cahiers D'Anesthesiologie. 1999;47(5):297–301.2
Ballatori E, Roila F, Salinaro F, et al. Ondansetron (OND) vs metoclopramide (MTC) both combined with dexamethasone (DEX) in the prevention of cisplatin (CDDP)-induced delayed emesis. The italian Group for Antiemetic Research. Supportive Care in Cancer. 1996;4(251).2
Basurto C, Corgna E, Picciafuoco M, et al. Cisplatin-induced delayed emesis: Pattern and prognostic factors during three subsequent cycles. Italian Group for Antiemetic Research. Annals of Oncology. 1994;5(7):585–589.2
Bhatia A, Tripathi KD, Sharma M. Comparison of ondansetron with metoclopramide in prevention of acute emesis associated with low dose & high dose cisplatin chemotherapy. Indian Journal of Medical Research. 2003;117(JULY):33–41.2
Bohn U, Aguiar J, Salinas J. Randomized cross-over trial of ondansetron (OND) and metoclopramide (MET) in the treatment of emesis induced by chemotherapy. Ann-Oncol. 1992;3(Suppl 5):187.2
Bohn U, Aguiar J, Salinas J. Randomized study comparing the efficacy of ondansetron and metoclopramide in the control of emesi induced by chemotherapy. Oncología. 1993;IV Congreso Nacional de la SEOM. 16(6):246.2
Bonneterre J, Chevallier B, Metz R, et al. A randomized double-blind comparison of ondansetron and metoclopramide in the prophylaxis of emesis induced by cyclophosphamide, fluorouracil, and doxorubucin or epirubicin chemotherapy. Journal of Clinical Oncology. 1990;8(6):1063–1069.2
Bonneterre J, Clavel M, the Ondansetron Breast Cancer Study G. Comparison between ondansetron (OND) tablet and alizapride (ALI) injection in the prevention of emesis induced by cytotoxic regimens in breast cancer patients. Ann-Oncol. 1992;3(Suppl 5):183.2
Bosi A, Guidi S, Messori A, et al. Ondansetron versus chlorpromazine for preventing emesis in bone marrow transplant recipients: A double-blind randomized study. Journal of Chemotherapy. 1993;5(3):191–196.2
Bosi A, Guidi S, Saccardi R, Vannucchi AM, Messori A, Rossi Ferrini P. Antiemetic prophylaxis with Ondansetron in BMT. European Journal of Cancer. 1991;27(Supp. 2):S297.5
Bosnjak SM, Neskovic-Konstantinovic ZB, Radulovic SS, Susnjar S, Mitrovic LB. High efficacy of a single oral dose of ondansetron 8 mg versus a metoclopramide regimen in the prevention of acute emesis induced by fluorouracil, doxorubicin and cyclophosphamide (FAC) chemotherapy for breast cancer. Journal of Chemotherapy. 2000;12(5):446–453.2
Bremer K. A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. The Granisetron Study Group. European Journal of Cancer. 1992;28A(6–7):1018- 1022.2
Bremer K, Hans K, Harjung H, Kurrle E, Uhlenbusch R. Granisetron (Gran), a selective 5-ht3-antagonist, compared to alizapride plus dexamethasone (comp) as antiemetics during five-day-cycles of cytotoxic chemotherapy. Ann-Oncol. 1990;1(Suppl):110.2
Bremer K, Hans K, Harjung H, Kurrle E, Uhlenbusch R. The antiemetic effectiveness of granisetron, compared with alizaprid + dexamethasone, in fractionated cytostatic therapy. Klinische Wochenschrift. 1991;69(Suppl 23):204.2
Bremer K, Smit P. Granisetron (G) compared to a combination of alizapride (A) plus dexamethason (D) for the prophylaxis and control of cytotoxic induce demesis over 5 days. Ann-Oncol. 1990;1(Suppl):109.2
Bremer K, Uhlenbusch R. 5-HT3-Receptor antagonist granisetron: antiemetic efficacy compared with alizaprid plus dexamethason during 5-day chemotherapy cycles. Onkologie. 1991;14(Suppl 3):20.2
Campora E, Giudici S, Merlini L, Rubagotti A, Rosso R. Ondansetron and dexamethasone versus standard combination antiemetic therapy: A randomized trial for the prevention of acute and delayed emesis induced by cyclophosphamide-doxorubicin chemotherapy and maintenance of antiemetic effect at subsequent courses. American Journal of Clinical Oncology: Cancer Clinical Trials. 1994;17(6):522–526.2
Campora E, Merlini L, Giudici S, Mammoliti S, Oliva C, Rosso R. Randomized trial of Ondansetron and Dexamethasone versus Metoclopramide, Dexamethasone and Orphenadrine for the control of acute and delayed FEC-FAC induced emesis. European Journal of Cancer. 1991;27(Supp. 2):S299.2
Campora E, Simoni C, Rosso R. Tropisetron versus ondansetron in the prevention and control of emesis in patients undergoing chemotherapy with FAC/FEC for metastatic or operated breast cancer. Minerva Med. 1994;85(1- 2):25–31.2
Carmichael J, Bessell EM, Harris AL, et al. Comparison of granisetron alone and granisetron plus dexamethasone in the prophylaxis of cytotoxic-induced emesis.[erratum appears in Br J Cancer 1995 May;71(5):1123]. British Journal of Cancer. 1994;70(6):1161–1164.2
Celik J, Reisli R, Tuncer S, Duman A, Okesli S. Prevention of postoperative nausea-vomiting in children: Comparison of granisetron and droperidol plus metoclopramide. Turk Anesteziyoloji Ve Reanimasyon. 2001;29(3):135–139.2
Celiker V, Celebi N, Canbay O, Basgul E, Aypar U. Minimum effective dose of dexamethasone after tonsillectomy. Paediatric Anaesthesia. 2004;14(8):666–669.2
Chang C-S, Chen L-T, Huang S-M, et al. Comparison of intravenous granisetron with metoclopramide plus dexamethasone in the prevention of nausea and vomiting associated with emetogenic cytotoxic chemotherapy. Kaohsiung Journal of Medical Sciences. 1997;13(2):97–102.2
Chen LJ, Xu L, Yang XC. Observation on curative effect of antinausea and antivomiting of ondansetron and droperidol in gynecology operation. Modern Medicine Health. 2002;18(3):177–178.2
Chen PP, Chui PT, Gin T. Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. European Journal of Anaesthesiology. 1996;13(5):485–491.2
Chevallier B. Efficacy and safety of granisetron compared with high-dose metoclopramide plus dexamethasone in patients receiving high-dose cisplatin in a single-blind study. European Journal of Cancer. 1990;26(SUPPL. 1):S33-S36.2
Chevallier B. The control of acute cisplatin-induced emesis - A comparative study of granisetron and a combination regimen of high-dose metoclopramide and dexamethasone. British Journal of Cancer. 1993;68(1):176–180.2
Chevallier B, Cappelaere P, Splinter T, Fabbro M, Claverie N. IV dolasetron (DM) vs IV metoclopramide (M) in emesis prevention after cisplatin chemotherapy (CT). Supportive Care in Cancer. 1995;3(336):16.2
Chevallier B, Cappelaere P, Splinter T, et al. A double-blind, multicentre comparison of intravenous dolasetron mesilate and metoclopramide in the prevention of nausea and vomiting in cancer patients receiving high-dose cisplatin chemotherapy. Supportive Care in Cancer. 7/7/2005 1997;5(1):22- 30.2
Chevallier B, Marty M, the Ondansetron Study g. A double blind randomized study to compare the efficacy and safety of ondansetron (ND) versus ondansetron plus methylprednisolone (MPD) in combination in the prophylaxis of cisplatin induced emesis. Ann-Oncol. 1992;3(Suppl 5):182.2
Chiou T-J, Wei C-H, Hsieh R-K, Fan FS, Liu J-H, Chen P-M. Comparison of intravenous granisetron with metoclopramide in the treatment of chemotherapy-induced emesis. Chinese Medical Journal (Taipei). 1995;56(1):23–30.2
Chiu EKW, Liang R, Lie A, Todd D, Chan TK. Comparison of ondansetron with metoclopramide in the control of emesis induced by moderately emetogenic chemotherapy used for lymphoma and leukaemia patients. Drug Investigation. 1994;8(2):104–109.2
Chung F, Lane R, Spraggs C, et al. Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. European Journal of Anaesthesiology. 1999;16(10):669–677.2
Climent MA, Palau J, Ruiz A, et al. The antiemetic efficacy of granisetron plus dexamethasone, haloperidol and loracepam in breast cancer patients treated with high-dose chemotherapy with peripheral blood stem-cell support. Supportive Care in Cancer. 1998;6(3):287–290.2
Collis Cea. The final assessment of a randomized double-blind comparative study of ondansetron vs metoclopramide in the prevention of nausea and vomiting following high-dose upper abdominal irradiation. Clinical Oncology (Royal College of Radiologists). 1991;3(4):241–242.5
Conte P, Ricci S, Antonuzzo A, et al. A double-blind randomized study comparing intramuscular (i.m.) granisetron with i.m. granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin. The Italian Multicenter Study Group. Anti-Cancer Drugs. 1999;10(5):465–470.2
Dabbous A, Itani M, Kawas N, et al. Post-laparoscopic vomiting in females versus males: comparison of prophylactic antiemetic action of ondansetron versus metoclopramide. Journal of the Society of Laparoendoscopic Surgeons. 1998;2(3):273–276.2
De Mulder PH, Seynaeve C, Vermorken JB, et al. Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin- induced nausea and vomiting. A multicenter, randomized, double-blind, crossover study. Annals of Internal Medicine. 1990;113(11):834–840.2
Del Favero A, Ballatori E, Olivieri A, et al. Difference in persistence of efficacy of two antiemetic regimens on acute emesis during cisplatin chemotherapy. Journal of Clinical Oncology. 1993;11(12):2396–2404.2
Depierre A, Lebeau B, Chevallier B, Votan B. Efficacy of ondansetron (O), metholprednisolone (M) plus metopimazine (MPZ) in patients previously uncontrolled with dual therapy in cisplatin containing chemotherapy. Ann- Oncol. 1996;7(Suppl 5):134.2
Depierre A, Lebeau B, d'Allens H. Comparison between the antiemetic efficacy of Ondansetron (OND) and Alizapride (ALI) plus Methylprednisolone (MPS) in patients receiving high dose Cisplatin in the treatment of lung cancer. European Journal of Cancer. 1991;27(Supp. 2):S172.2
Depierre A, Lebeau B, D'Allens H. A comparison of ondansetron with alizapride plus methylprednisolone in the control of cisplatin-induced emesis. Oncology. 1992;49(4):305–311.2
DeSilva PHDP, Darvish AH, McDonald SM, Cronin MK, Clark K. The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesthesia and Analgesia. 1995;81(1):139–143.2
Dick GS, Meller ST, Pinkerton CR. Randomised comparison of ondansetron and metoclopramide plus dexamethasone for chemotherapy induced emesis. Archives of Disease in Childhood. 1995;73(3):243–245.2
Diehl V. Fractionated chemotherapy - Granisetron or conventional antiemetics? European Journal of Cancer Part A: General Topics. 1992;28(SUPPL. 1):S 21-S 28.2
Dresner M, Dean S, Lumb A, Bellamy M. High-dose ondansetron regimen vs droperidol for morphine patient-controlled analgesia. British Journal of Anaesthesia. 1998;81(3):384–386.2
du Bois A, erson H, Lahousen M, et al. Efficacy of ondansetron and metoclopramide (with dexamethasone): in the prevention of carboplatin- induced emesis. Supportive Care in Cancer. 1995;3(343):39.2
du Bois A, McKenna CJ, Andersson H, et al. A randomised, double-blind, parallel-group study to compare the efficacy and safety of ondansetron (GR38032F) plus dexamethasone with metoclopramide plus dexamethasone in the prophylaxis of nausea and emesis induced by carboplatin chemotherapy. Oncology. 1997;54(1):7–14.2
Eberhart LHJ, Morin AM, Hoerle S, Wulf H, Geldner G. Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Ophthalmology. 2004;111(8):1569–1575.2
Esseboom EU, Rojer RA, Borm JJ, Statius van Eps LW. Prophylaxis of delayed nausea and vomiting after cancer chemotherapy. Netherlands Journal of Medicine. 1995;47(1):12–17.2
Evans C, Stein RC, Davenport J, Dougherty L, Carruthers L, Coombes RC. Comparison of antiemetic efficacy of ondansetron with dexamethasone plus domperidone in refractory nausea and vomiting in patients receiving non- cisplatinum chemotherapy regimens. Journal of Cancer Research & Clinical Oncology. 1990;116(Suppl):640.2
Evans C, Stein RC, Davenport J, Dougherty L, Carruthers L, Coombes RC. Comparison of enti-emetic efficacy of ondansetron with dexamethasone plus domperidone in refractory nausea and vomiting in patients receiving non- cisplatin chemotherapy regimens. European Journal of Cancer. 1991;27(Suppl. 1):S 25.2
Fanning J, Hilgers RD. Ondansetron and metoclopramide fail to prevent vomiting secondary to ultra-high-dose cisplatin-carboplatin chemotherapy. Obstetrics and Gynecology. 1994;83(4):601–604.2
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Ohmatsu H, Eguchi K, Shinkai T, et al. A randomized cross-over study of high-dose metoclopramide plus dexamethasone versus granisetron plus dexamethasone in patients receiving chemotherapy with high-dose cisplatin. Japanese Journal of Cancer Research. 1994;85(11):1151–1158.2
Ohwada M, Suzuki M, Ogawa S, Tamada T, Sato I. Efficacy and tolerability of granisetron with betamethasone, an antiemetic combination, in gynecologic cancer patients receiving cisplatin. Current Therapeutic Research - Clinical and Experimental. 1995;56(10):1059–1065.2
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Paech MJ, Lee BH, Evans SF. The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy. Anaesthesia & Intensive Care. 2002;30(2):153–159.2
Peixoto AJ, Peixoto Filho AJ, Leaes LF, Celich MF, Barros MAV. Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial. European Journal of Anaesthesiology. 2000;17(10):611–615.2
Piper SN, Triem JG, Waleck WH, Schmidt CC, Boldt J. Prophylaxis of PONV after hysterectomy with oral Dolasetron, intravenous Dehydrobenzperidol (DHB) or a combination therapy with both drugs. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 1999;34(Suppl 2):S116.2
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Prentice HG. Efficacy and safety of intravenous granisetron compared with a standard anti-emetic therapy in patients undergoing total body irradiation (TBI) prior to bone marrow transplantation (BMT). Ann-Oncol. 1992;3(Suppl 5):186.2
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Priestman TJ, Roberts JT, Upadhyaya BK. Randomised, double-blind trial of ondansetron (OND) and prochlorperazine (PCP) in the prevntion of fractionated radiotherapy (RT). Ann-Oncol. 1992;3(Suppl 5):185.5
Pugh SC, Jones NC, Barsoum LZ. A comparison of prophylactic ondansetron and metoclopramide administration in patients undergoing major neurosurgical procedures. Anaesthesia. 1996;51(12):1162–1164.2
Quaynor H, Raeder JC. Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiologica Scandinavica. 2002;46(1):109–113.2
Raphael JH, Norton AC. Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: Randomized, double-blind comparison with metoclopramide. British Journal of Anaesthesia. 1993;71(6):845–848.2
Rath U, Upadhyaya BK, Arechavala E, et al. Role of ondansetron plus dexamethasone in fractionated chemotherapy. Oncology. 1993;50(3):168–172.2
Raynov J, Danon S, Valerianova Z. Control of acute emesis in repeated courses of moderately emetogenic chemotherapy. Journal of B.U.ON. 2002;7(1):57–60.2
Roila F. Ondansetron plus dexamethasone compared to the 'standard' metoclopramide combination. Oncology. 1993;50(3):163–167.2
Roila F. Persistence of efficacy of three antiemetic regimens and prognostic factors in patients undergoing moderately emetogenic chemotherapy. Journal of Clinical Oncology. 1995;13(9):2417–2426.2
Roila F, Ballatori E, Contu A, et al. Ondansetron (OND) vs metoclopramide (MTC) both combined with dexametasone (DEX) in the prevention of cisplatin (CDDP)-induced delayed emesis. Tumori. 1996;82(60).2
Roila F, Ballatori E, De Angelis V, et al. Dexamethasone, granisetron, or both for the prevention of nausea and vomiting during chemotherapy for cancer. New England Journal of Medicine. 1995;332(1):1–5.2
Roila F, Tonato M, Ballatori E, et al. Ondansetron + dexamethasone vs metoclopramide + dexamethasone + diphenhydramine in prevention of cisplatin-induced emesis. Lancet. 1992;340(8811):96–99.2
Roila F, Tonato M, Favalli G, Scarfone G, Cognetti F, Buzzi F. A multicenter double-blind study comparing the antiemetic efficacy and safety of ondansetron (OND) plus dexamethasone (dex) vs metoclopramide (MTC) plus dex and diphenhydramine (DIP) in cisplatin (CDDP) treated cancer patients (Pts). Ann-Oncol. 1992;3(Suppl 5):183.2
Roila F, Tonato M, Favalli G, et al. Persistence of efficacy of Ondansetron (OND) plus Dexamethasone (DEX) vs Metoclopramide (MTC) plus DEX and Diphenhydramine (DIP) in acute emesis during three consecutive cycles of Cisplatin (CDDP) chemotherapy (CT). European Journal of Cancer. 1993;29Ÿ(Supp. 6):S207.2
Sanchez-Ledesma MJ, Lopez-Olaondo L, Pueyo FJ, Carrascosa F, Ortega A. A comparison of three antiemetic combinations for the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia. 2002;95(6):1590–1595.2
Sandoval C, Corbi D, Strobino B, Ozkaynak MF, Tugal O, Jayabose S. Randomized double-blind comparison of single high-dose ondansetron and multiple standard-dose ondansetron in chemotherapy-naive pediatric oncology patients. Cancer Investigation. 1999;17(5):309–313.2
Sands R, Roberts JT, Marsh M, Gill A. Low dose ondansetron and dexamethasone: a cost effective alternative to high dose metoclopramide/dexamethasone/lorazepam in the prevention of acute cisplatin induced emesis. Clin Oncol (R Coll Radiol). Jan 1992;4(1):67.2
Sanjay OP, Tauro DI. Midazolam: an effective antiemetic after cardiac surgery--a clinical trial. Anesthesia & Analgesia. 2004;99(2):339–343.2
Sigsgaard T, Herrstedt J, Andersen LJ, et al. Granisetron compared with prednisolone plus metopimazine as anti-emetic prophylaxis during multiple cycles of moderately emetogenic chemotherapy. British Journal of Cancer. 1999;80(3–4):412–418.2
Sigsgaard T, Herrstedt J, Christensen P, Andersen O, Dombernowsky P. Antiemetic efficacy of combination therapy with granisetron plus prednisolone plus the dopamine D2 antagonist metopimazine during multiple cycles of moderately emetogenic chemotherapy in patients refractory to previous antiemetic therapy. Supportive Care in Cancer. 2000;8(3):233–237.2
Sismondi P, Danese S, Giardina G, et al. Antiemetic efficacy of granisetron in patients with gynecological malignancies. Anti-Cancer Drugs. 1997;8(3):225–230.2
Skarlos DV, Pavlidis N, Fountzilas G, et al. Ondansetron (O) vs Metoclopramide in Carboplatinum containing regimens. European Journal of Cancer. 1991;27(Supp. 2):S296.2
Sledge GW, Jr., Einhorn L, Nagy C, House K. Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy. Cancer. 1992;70(10):2524–2528.2
Smith IE. Anti-emetic treatment with granisetron in patients receiving moderately emetogenic chemotherapy. European Journal of Clinical Research. 1994;5(-):193–202.2
Sniadach MS, Alberts MS. A comparison of the prophylactic antiemetic effect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy. Anesthesia and Analgesia. 1997;85(4):797–800.2
Solano JB, Becerra JB, Jimenez TD. Nausea and vomit in the immediate postoperative period. Propofol vs ondansetron. Anestesia en Mexico. 1999;11(5):172–177.2
Somri M, Vaida SJ, Sabo E, Yassain G, Gankin I, Gaitini LA. Acupuncture versus ondansetron in the prevention of postoperative vomiting: A study of children undergoing dental surgery. Anaesthesia. 2001;56(10):927–932.2
Sontakke S, Thawani V, Naik MS. Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study. Indian Journal of Pharmacology. 2003;35(1):32–36.2
Soukop M. Management of cyclophosphamide-induced emesis over repeat courses. Oncology. 1996;53(SUPPL. 1):39–45.5
Splinter WM, Rhine EJ, Roberts DJ. Vomiting after strabismus surgery in children: ondansetron vs propofol. Canadian Journal of Anaesthesia. 1997;44(8):825–829.2
Splinter WM, Rhine EJ, Roberts DW, et al. Ondansetron is a better prophylactic antiemetic than droperidol for tonsillectomy in children. Canadian Journal of Anaesthesia. 1995;42(10):848–851.2
Steinbrook RA, Gosnell JL, Freiberger D. Prophylactic antiemetics for laparoscopic cholecystectomy: A comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. Journal of Clinical Anesthesia. 1998;10(6):494–498.2
Stiakaki E, Savvas S, Lydaki E, et al. Ondansetron and tropisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapy. Pediatric Hematology and Oncology. 1999;16(2):101–108.2
Stienstra R, Samhan YM, El-Mofty M, De Bont LEA, Bovill JG. Double-blind comparison of alizapride, droperidol and ondansetron in the treatment of post-operative nausea. European Journal of Anaesthesiology. 1997;14(3):290–294.2
Sullivan CA, Johnson CA, Roach H, Martin RW, Stewart DK, Morrison JC. A prospective, randomized, double-blind comparison of the serotonin antagonist ondansetron to a standardized regimen of promethazine for hyperemesis gravidarum. A preliminary investigation. American Journal of Obstetrics and Gynecology. 1995;172(299).5
Sundstrom GM, Wahlin A. Comparison of efficacies of ondansetron and dixyrazine for prophylaxis of emesis during induction treatment in acute myelogenous leukemia - A pilot study. Acta Oncologica. 1997;36(2):229–230.2
Swiatkowski J, Goral A, Dzieciuch JA, Przesmycki K. Assessment of ondansetron and droperidol for the prevention of post-operative nausea and vomiting after cholecystectomy and minor gynaecological surgery performed by laparoscopy. European Journal of Anaesthesiology. 1999;16(11):766–772.2
Szarvas S, Chellapuri RS, Harmon DC, Owens J, Murphy D, Shorten GD. A comparison of dexamethasone, ondansetron, and dexamethasone plus ondansetron as prophylactic antiemetic and antipruritic therapy in patients receiving intrathecal morphine for major orthopedic surgery. Anesthesia and Analgesia. 2003;97(1):259–263.2
Terrey JP, Aapro M, Kirchner Z, Alberto P. Patient preference of antiemetic treatment: a placebo controlled double blind comparison of granisetron with granisetron plus dexamethasone. European Journal of Cancer. 1995;31Ÿ(Suppl 5):S186 Abs. 895.2
Thomas R, Jones N. Prospective randomized, double-blind comparative study of dexamethasone, ondansetron, and ondansetron plus dexamethasone as prophylactic antiemetic therapy in patients undergoing day-case gynaecological surgery. British Journal of Anaesthesia. 2001;87(4):588–592.2
Thompson JF, Malouf DJ, Merzliakov S, Kam PCA. Efficacy of single-dose ondansetron in the prevention of post-operative nausea and vomiting following isolated limb perfusion with cytotoxic agents. Regional Cancer Treatment. 1993;6(4):177–182.2
Tonato M. Ondansetron plus dexamethasone: An effective combination in high-dose cisplatin therapy. European Journal of Cancer. 1991;27(SUPPL. 1):S12–S14.2
Tramer MR, Sansonetti A, Fuchs-Buder T, Rifat K. Oculocardiac reflex and postoperative vomiting in paediatric strabismus surgery. A randomised controlled trial comparing four anaesthetic techniques. Acta Anaesthesiologica Scandinavica. 1998;42(1):117–123.2
Tsavaris N, Charalambidis G, Ganas N, et al. Ondansetron versus metoclopramide as antiemetic treatment during cisplatin-based chemotherapy. A prospective study with special regard to electrolyte imbalance. Acta Oncologica. 1995;34(2):243–246.2
Tsavaris N, Charalambidis G, Pagou M, et al. Comparison of ondansentron (GR 38032F) versus ondansentron plus alprazolam as antiemetic prophylaxis during cisplatin-containing chemotherapy. American Journal of Clinical Oncology: Cancer Clinical Trials. 1994;17(6):516–521.2
Tsavaris N, Mylonakis N, Bacoyiannis C, Katsikas M, Lioni A, Kosmidis P. Comparison of ondansentron versus ondansentron plus methylprednisolone as antiemetic prophylaxis during cisplatin-containing chemotherapy. Journal of Pain and Symptom Management. 1994;9(4):254–258.2
Tsavaris NB, Koufos C, Katsikas M, Dimitrakopoulos A, Athanasiou E, Linardaki G. Antiemetic prophylaxis with ondansetron and methylprednisolone vs metoclopramide and methylprednisolone in mild and moderately emetogenic chemotherapy. Journal of Pain and Symptom Management. 1999;18(3):218–222.2
Tsukada H, Hirose T, Yokoyama A, Kurita Y. Randomised comparison of ondansetron plus dexamethasone with dexamethasone alone for the control of delayed cisplatin-induced emesis. European Journal of Cancer. 2001;37(18):2398–2404.2
Tsukuda M, Furukawa S, Kokatsu T, Enomoto H, Kubota A, Furukawa M. Comparison of granisetron alone and granisetron plus hydroxyzine hydrochloride for prophylactic treatment of emesis induced by cisplatin chemotherapy. European Journal of Cancer Part A: General Topics. 1995;31(10):1647–1649.2
Tsukuda M, Kokatsu T, Furukawa S, et al. Comparison of granisetron alone and granisetron plus hydroxyzine hydrochloride for the prophylactic treatment of emesis induced by cisplatin- containing chemotherapy. Japanese Journal of Cancer and Chemotherapy. 1993;20(13):2037–2041.2
Turhanoglu S, Ozyilmaz MA, Tok D, Olmez G, Cinar FS, Bayhan N. A comparison of the effects of ondansetron with or without dimenhydrinate in the prevention of nausea and vomiting after major gynaecological surgery. Acta Anaesthesiologica Italica / Anaesthesia and Intensive Care in Italy. 1999;50(3):193–199.2
Uchida K, Akaza H, Shimazui T, et al. Comparison of clinical effects between granisetron alone and combination of granisetron and methylprednisolone against the nausea and vomiting induced by CDDP chemotherapy comparative study by the cross-over trial. Japanese Journal of Cancer and Chemotherapy. 1996;23(1):81–86.2
Ummenhofer W, Frei FJ, Urwyler A, Kern C, Drewe J. Effects of ondansetron in the prevention of postoperative nausea and vomiting in children. Anesthesiology. 1994;81(4):804–810.2
Unlugenc H, Guler T, Gunes Y, Isik G. Comparative study of the antiemetic efficacy of ondansetron, propofol and midazolam in the early postoperative period. European Journal of Anaesthesiology. 2003;20(8):668–673.2
Unlugenc H, Guler T, Gunes Y, Isik G. Comparative study of the antiemetic efficacy of ondansetron, propofol and midazolam in the early postoperative period. European Journal of Anaesthesiology. 2004;21(1):60–65.5
Usmani H, Quadir A, Siddiqui RA, Sharma SC. Ondansetron and dexamethasone in middle ear procedures. Indian Journal of Otolaryngology and Head and Neck Surgery. 2003;55(2):97–99.2
Van den Berg AA. Comparison of ondansetron and prochlorperazine for the prevention of nausea and vomiting after adenotonsillectomy. British Journal of Anaesthesia. 1996;76(3):449–451.2
van den Berg AA, Savva D. Prevention of PONV following ENT surgery: controlled comparison of ondansetron and prochlorperazine [abstract]. Br J Anaesth. 1995;74(1):91.2
Victor MA, Jorgensen M. Antiemetic efficacy of Ondansetron and Corticosteroid in patients receiving chemotherapy for malignant lymphoma. European Journal of Cancer. 1993;29Ÿ(Supp. 6):S210.2
Wan-Yong Z. Combined use of ondansetron and other anti-emetics to control cisplatin- induced nausea and vomiting. Chinese Journal of Oncology. 1993;15(2):118–121.2
Warr D, Wilan A, Venner P, et al. A randomised, double-blind comparison of granisetron with high-dose metoclopramide, dexamethasone and diphenhydramine for cisplatin-induced emesis. An NCI Canada Clinical Trials Group Phase III Trial. European Journal of Cancer. 1992;29A(1):33–36.2
Warr D, Willan A, Fine S, et al. Superiority of granisetron to dexamethasone plus prochlorperazine in the prevention of chemotherapy-induced emesis. Journal of the National Cancer Institute. 1991;83(16):1169–1173.2
Warrick PD, Belo SE. Treating 'rebound' emesis following outpatient gynecologic laparoscopy: The efficacy of a two-dose regimen of droperidol and ondansetron. Journal of Clinical Anesthesia. 1999;11(2):119–125.2
Watts SA. A randomized double-blinded comparison of metoclopramide, ondansetron and cyclizine in day-case laparoscopy. Anaesthesia and Intensive Care. 1996;24(5):546–551.2
Wattwil M, Thorn S-E, Lovqvist A, Wattwil L, Gupta A, Liljegren G. Dexamethasone is as effective as ondansetron for the prevention of postoperative nausea and vomiting following breast surgery. Acta Anaesthesiologica Scandinavica. 2003;47(7):823–827.2
Wilson EB, Bass CS, Abrameit W, Roberson R, Smith RW. Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy. American Journal of Surgery. 2001;181(2):138–141.2
Winston AW, Rinehart RS, Riley GP, Vacchiano CA, Pellegrini JE. Comparison of inhaled isopropyl alcohol and intravenous ondansetron for treatment of postoperative nausea. Journal of the American Association of Nurse Anesthetists. 2003;71(2):127–132.2
Woodward DK, Sherry KM, Harrison D. Antiemetic prophylaxis in cardiac surgery: Comparison of metoclopramide and ondansetron. British Journal of Anaesthesia. 1999;83(6):933–935.2
Wrench IJ, Ward JE, Walder AD, Hobbs GJ. The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol. Anaesthesia. 1996;51(8):776–778.2
Xynogalos S, Vaslamatzis M, Alexopoulos CG. Ondansetron (ODS) + metoclopramide (MTP) + dexamethasone (DXM) vs ondansetron + dexamethasone during CDDP based chemotherapy (CT). European Journal of Cancer. 1995;31Ÿ(Suppl 5):A261 Abs 1252.2
Yamaguchi T, Niitani H, Hasegawa K, Furue H. Randomized comparitor study with crossover of Granisetron versus high-dose Methylprednisolone (MP) in the treatment of Cisplatin-induced emesis. European Journal of Cancer. 1991;27(Supp. 2):S296.2
Yang MH, Zhang ZL. Comparison of ondansetron with droperidol in prophylaxis of nausea or vomiting during curative operation of gastric cancer. Chinese Journal of New Drugs and Clinical Remedies. 2002;21(11):669–671.2
Yoshizawa M, Chida M, Ichioka M, et al. Prevention of nausea and vomiting induced by chemotherapy with cisplatin plus vindesine in non-small cell lung cancer patients: A prospective randomized trial comparing granisetron with granisetron plus moderate-dose methylprednisolone. Japanese Journal of Lung Cancer. 1995;35(4):417–423.2
Zaluski J, Puistola U, Madej G. Ondansetron plus dexamethasone, ondansetron and tropisetron in the prophylaxis of cisplatin-induced acute emesis: a multicentre, double-blind, randomized, parallel group study. The Emesis Study Group. European Journal of Clinical Research. 1997;9:21–31.2
Placebo-controlled trials
Abouleish EI, Rashid S, Haque S, Giezentanner A, Joynton P, Chuang AZ. Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia. Anaesthesia. 1999;54(5):479–482.2
Akcabay M, Gunaydin B, Mahli A, Karadenizli Y. Ondansetron versus placebo to prevent postoperative nausea and vomiting in patients undergoing thyroidectomy. Gazi Medical Journal. 1997;8(2):54–57.1
Awad IT, Murphy D, Stack D, Swanton BJ, Meeke RI, Shorten GD. A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy. Journal of Clinical Anesthesia. 2002;14(7):481–485.2
Bacic A, Rumboldt Z, Gluncic I, Buklijas J. The impact of the menstrual cycle and ondansetron on postoperative nausea and vomiting. International Journal of Clinical Pharmacology Research. 1998;18(4):153–158.2
Barst SM, Leiderman JU, Markowitz A, Rosen AM, Abramson AL, Bienkowski RS. Ondansetron with propofol reduces the incidence of emesis in children following tonsillectomy. Canadian Journal of Anaesthesia. 1999;46(4):359–362.2
Beck T, York M, Chang A, et al. Oral ondansetron 8 MG BID is as effective as 8 MG TID in the prevention of nausea and vomiting associated with cyclophosphamide-based chemotherapy. Breast Cancer Research & Treatment. 1996;37(Suppl):92–92.5
Beck TM. Efficacy of ondansetron tablets in the management of chemotherapy-induced emesis: Review of clinical trials. Seminars in Oncology. 1992;19(6 SUPPL. 15):20–25.2
Beck TM. The pattern of emesis following high-dose cyclophosphamide and the anti-emetic efficacy of ondansetron. Anti-Cancer Drugs. 1995;6(2):237–242.2
Beck TM, Ciociola AA, Jones SE, et al. Efficacy of oral ondansetron in the prevention of emesis in outpatients receiving cyclophosphamide-based chemotherapy. The Ondansetron Study Group. Annals of Internal Medicine. 1993;118(6):407–413.2
Bey P, Wilkinson PM, Claverie N. IV dolasetron mesilate in the prevention of radiotherapy-induced nausea and vomiting. Supportive Care in Cancer. 1995;3(342).5
Bharti N, Shende D. Comparison of anti-emetic effects of ondansetron and low-dose droperidol in pediatric strabismus surgery. Journal of Pediatric Ophthalmology and Strabismus. 2003;40(1):23–26.2
Binstock W, Rubin R, Bachman C, Kahana M, Mcdade W, Lynch JP. The effect of premedication with OTFC, with or without ondansetron, on postoperative agitation, and nausea and vomiting in pediatric ambulatory patients. Paediatric Anaesthesia. 2004;14(9):759–767.2
Biswas BN, Rudra A, Mandal SK. Comparison of ondansetron, dexamethasone, ondansetron plus dexamethasone and placebo in the prevention of nausea and vomiting after laparoscopic tubal ligation. Journal of the Indian Medical Association. 2003;101(11):638–642.2
Bodner M, White PF. Antiemetic efficacy of ondansetron after outpatient laparoscopy. Anesthesia and Analgesia. 1991;73(3):250–254.2
Borgeat A, Tazlari G, Balmer A, Tramer M, Rifat K. Does ondansetron decrease the incidence of postoperative nausea/vomiting after strabismus surgery in children? [abstract]. Br J Anaesth. 1995;74(1):99.5
Bouly A, Nathan N, Feiss P. Prevention of post-operative nausea and vomiting using oral ondansetron [abstract]. Eur J Anaesthesiol. 1993;10(71).5
Bowhay AR, May HA, Rudnicka AR, Booker PD. A randomized controlled trial of the antiemetic effect of three doses of ondansetron after strabismus surgery in children. Paediatric Anaesthesia. 2001;11(2):215–221.2
Bugedo G, Gonzalez J, Asenjo C, et al. Ondansetron and droperidol in the prevention of postoperative nausea and vomiting. British Journal of Anaesthesia. 1999;83(5):813–814.2
Buser KS, Joss RA, Piquet D, et al. Oral ondansetron in the prophylaxis of nausea and vomiting induced by cyclophosphamide, methotrexate and 5–fluorouracil (CMF) in women with breast cancer. Results of a prospective, randomized, double-blind, placebo-controlled study. Annals of Oncology. 1993;4(6):475–479.2
Calamandrei M, Andreuccetti T, Crescioli M, et al. Effects of ondansetron and metoclopramide on postoperative nausea and vomiting after epidural anaesthesia in an infant. Cah Anesthesiol. 1994;42(1):19–23.1
Campbell C, Miller DD. Failure of ondansetron to control postoperative nausea and vomiting in ambulatory surgical patients. American Journal of Anesthesiology. 1995;22(2):81–86.2
Chen LK, Fan SZ, Huang CH, et al. Effects of ondansetron on postoperative emesis in Chinese children. Acta Anaesthesiologica Sinica. 1998;36(2):87–91.2
Claybon L. Single dose intravenous ondansetron for the 24-hour treatment of postoperative nausea and vomiting. Anaesthesia. 1994;49(SUPPL.):24–29.2
Creed M, Brogden J, Ames M, Bryson J. Oral ondansetron (OND) for the prevention of acute nausea and vomiting (N/V) in highly emetogenic cisplatin (CDDP)-based chemotherapy regimens. Supportive Care in Cancer. 1999;7(176):44.2
Cubeddu LX, Hoffman IS, Fuenmayor NT, Finn AL. Antagonism of serotonin S3 receptors with ondansetron prevents nausea and emesis induced by cyclophosphamide-containing chemotherapy regimens. Journal of Clinical Oncology. 1990;8(10):1721–1727.2
Cubeddu LX, Hoffmann IS, Fuenmayor NT, Finn AL. Efficacy of ondansetron (GR 38032F) and the role of serotonin in cisplatin-induced nausea and vomiting. New England Journal of Medicine. 1990;322(12):810–816.2
Cubeddu LX, Pendergrass K, Ryan T, et al. Efficacy of oral ondansetron, a selective antagonist of 5-HT3 receptors, in the treatment of nausea and vomiting associated with cyclophosphamide- based chemotherapies. American Journal of Clinical Oncology: Cancer Clinical Trials. 1994;17(2):137–146.2
Cupissol DR, Serrou B, Caubel M. The efficacy of granisetron as a prophylactic anti-emetic and intervention agent in high-dose cisplatin-induced emesis. European Journal of Cancer. 1990;26(1).2
Daftary S, Jagtap SR, Saksena S. Intravenous Ondansetron in prevention of PONV following tonsillectomy under ether anaesthesia. Journal of Anaesthesiology Clinical Pharmacology. 1998;14(1):51–54.2
Davies PR, Warwick P, O'Connor M. Antiemetic efficacy of ondansetron with patient-controlled analgesia. Anaesthesia. 1996;51(9):880–882.2
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Rodrigo C, Campbell R, Chow J, Tong A. The effect of a 4-Mg preoperative intravenous dose of ondansetron in preventing nausea and vomiting after maxillofacial surgery. Journal of Oral and Maxillofacial Surgery. 1996;54(10):1171–1175.2
Rodrigo MRC, Campbell RC, Chow JC, Tong A, Chow KC. Single pre-operative dose of ondansetron for nausea and vomiting following maxillofacial surgery. (Abstract - Hong Kong Congress). Int Dent J. 1995;45(Oct):304.2
Rodrigo MRC, Campbell RCH, Chow J, Tong CKA, Hui E, Lueveswanij S. Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: A double-blind randomized study. Anaesthesia and Intensive Care. 1994;22(5):576–579.2
Rose JB, Brenn BR, Corddry DH, Thomas PC. Preoperative oral ondansetron for pediatric tonsillectomy. Anesthesia and Analgesia. 1996;82(3):558–562.2
Rose JB, Martin TM. Posttonsillectomy vomiting. Ondansetron or metoclopramide during paediatric tonsillectomy: are two doses better than one? Paediatric Anaesthesia. 1996;6(1):39–44.2
Rung GW, Claybon L, Hord A, et al. Intravenous ondansetron for postsurgical opioid-induced nausea and vomiting. Anesthesia and Analgesia. 1997;84(4):832–838.2
Rust M, Cohen LA. Single oral dose ondansetron in the prevention of postoperative nausea and emesis. Anaesthesia. 1994;49(SUPPL.):16–23.2
Sadhasivam S, Shende D, Madan R. Prophylactic ondansetron in prevention of postoperative nausea and vomiting following pediatric strabismus surgery: A dose-response study. Anesthesiology. 2000;92(4):1035–1042.2
Samarkandi AH, Riad W, Altaf R, Fatani R. Dexamethasone-odansetron combination in prevention of nausea and vomiting after strabismus surgery in children. Egyptian Journal of Anaesthesia. 2004;20(4):399–403.2
Saur VP, Muhr C, Kazmaier S, Neumann P, Buhre W. Prophylaxis of postoperative nausea and vomiting using single and repetitive doses of ondansetron - An overview of literature on application methods. Anaesthesiologie Und Reanimation. 1996;21(5):131–135.2
Scholz J, Hennes HJ, Steinfath M, et al. Tropisetron or ondansetron compared with placebo for prevention of postoperative nausea and vomiting. European Journal of Anaesthesiology. 1998;15(6):676–685.2
Scuderi P, Wetchler B, Sung Y-F, et al. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology. 1993;78(1):15–20.2
Scuderi PE, James RL, Harris L, Mims III GR. Multimodal antiemetic management prevents early postoperative vomiting after outpatient laparoscopy. Anesthesia and Analgesia. 2000;91(6):1408–1414.6
Scuderi PE, Weaver Jr. RG, James RL, Mims G, Elliott WG, Weeks DB. A randomized, double-blind, placebo controlled comparison of droperidol, ondansetron, and metoclopramide for the prevention of vomiting following outpatient strabismus surgery in children. Journal of Clinical Anesthesia. 1997;9(7):551–558.2
Seynaeve C, Schuller J, Buser K, et al. Comparison of the anti-emetic efficacy of different doses of ondansetron, given as either a continuous infusion or a single intravenous dose, in acute cisplatin-induced emesis. A multicentre, double-blind, randomised, parallel group study. British Journal of Cancer. 1992;66(1):192–197.2
Sharma S, Abdullah N. A comparison of commonly used anti-emetics for the prevention of emetic sequelae after a major gynaecological surgery. Singapore Medical Journal. 2000;41(4):147–150.2
Shende D, Bharti N, Kathirvel S, Madan R. Combination of droperidol and ondansetron reduces PONV after pediatric strabismus surgery more than single drug therapy. Acta Anaesthesiologica Scandinavica. 2001;45(6):756–760.2
Shende D, Mandal NG. Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children. Anaesthesia. 1997;52(5):496–500.2
Sinha PK, Ambesh SP. Ondansetron in prophylaxis of postoperative nausea and vomiting in patients undergoing breast surgery: A placebo-controlled double blind study. Journal of the Indian Medical Association. 2004;102(2):73–79.2
Sinha PK, Tripathi M, Ambesh SP. Efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting in patients following infratentorial surgery: A placebo-controlled prospective double-blind study. Journal of Neurosurgical Anesthesiology. 1999;11(1):6–10.2
Skraastad O, Stubhaug A, Dodgson M, Breivik H. Antiemetic prophylaxis in pediatric strabismus surgery. A double-blind comparison of ondansetron, ephedrine and placebo. Acta Anaesthesiol Scand. 1995;39(suppl 105):159.2
So JBY, Cheong KF, Sng C, Cheah WK, Goh P. Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: A prospective randomized study. Surgical Endoscopy. 2002;16(2):286–288.2
Spitzer TR, Bryson JC, Cirenza E, et al. A randomized, double-blind, placebo-controlled trial of ondansetron (OND) in the prevention of total body irradiation (TBI) induced emesis. Blood. 1993;82(10 Suppl 1):419a.5
Splinter WM. Prevention of vomiting after strabismus surgery in children: Dexamethasone alone versus dexamethasone plus low-dose ondansetron. Paediatric Anaesthesia. 2001;11(5):591–595.2
Splinter WM, Baxter MR, Gould HM, et al. Oral ondansetron decreases vomiting after tonsillectomy in children. Canadian Journal of Anaesthesia. 1995;42(4):277–280.2
Suen TK, Gin TA, Chen PP, Rowbottom YM, Critchley LA, Ray AK. Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery. Anaesthesia & Intensive Care. 1994;22(2):142–146.2
Suminaga M, Furue H, Ohta K, Taguchi T, Niitani H, Ogawa N. Clinical evaluation of granisetron for nausea and vomiting induced by anticancer drugs - Multi centered placebo controlled double-blind comparative study. Japanese Journal of Cancer and Chemotherapy. 1993;20(9):1211–1219.2
Sung YF, Wetchler BV, Duncalf D, Joslyn AF. A double-blind, placebo-controlled pilot study examining the effectiveness of intravenous ondansetron in the prevention of postoperative nausea and emesis. Journal of Clinical Anesthesia. 1993;5(1):22–29.2
Taylor AM, Rosen M, Diemunsch PA, Thorin D, Houweling PL. A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia. Journal of Clinical Anesthesia. 1997;9(8):658–663.2
Triem JG, Piper SN, Maleck WH, Schenck A, Schmidt CC, Boldt J. Prevention of postoperative nausea and vomiting (PONV) with single oral dose of dolasetron, compared to single dose of intravenous droperidol and a combination of both substances in patients undergoing hysterectomy. Objective. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 1999;34(6):340–344.1
Tsui SL, Ng KFJ, Wong LC, Tang GWK, Pun TC, Yang JCS. Prevention of postoperative nausea and vomiting in gynaecological laparotomies: A comparison of tropisetron and ondansetron. Anaesthesia and Intensive Care. 1999;27(5):471–476.2
Tzeng JI, Chu KS, Ho ST, Cheng KI, Liu KS, Wang JJ. Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. Canadian Journal of Anaesthesia. 2003;50(10):1023–1026.2
Uchida K, Akaza H, Hattori K, et al. Antiemetic efficacy of granisetron: a randomized crossover study in patients receiving cisplatin-containing intraarterial chemotherapy. Japanese Journal of Clinical Oncology. 1999;29(2):87–91.2
Ulusoy HO, Akturk G, Luleci N, Kalac N, Albayrak D. Prophylactic administration of ondansetron in emergency intraabdominal operations. Middle East Journal of Anesthesiology. 1996;13(5):513–526.2
Ulusoy HO, Akturk G, Luleci N, Kalac N, Albayrak D. Prophylactic administration of ondansetron in emergency intraabdominal operations. Middle East Journal of Anesthesiology. 1997;14(1):45–58.2
Usha Rani P, Rama Raju GA, Naidu MUR, et al. Randomised, double blind, placebo controlled study of Ondansetron in female patients undergoing day case surgery. Journal of Anaesthesiology Clinical Pharmacology. 1996;12(1):31–34.2
Van Den Berg AA. The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: A randomized double-blind comparison. Anaesthesia and Intensive Care. 1996;24(5):538–545.2
Van den Berg AA. A comparison of ondansetron and prochlorperazine for the prevention of nausea and vomiting after tympanoplasty. Canadian Journal of Anaesthesia. 1996;43(9):939–945.2
Volpe N, Gesini A, Collini S, et al. Single dose ondansetron for prevention of postoperative nausea and vomiting. Results from the Italian Multicentre Ondansetron Study. Drug Investigation. 1994;8(2):67–72.2
Wagley C, Hackett C, Haug RH. The effect of preoperative ondansetron on the incidence of postoperative nausea and vomiting in patients undergoing outpatient dentoalveolar surgery and general anesthesia. Journal of Oral and Maxillofacial Surgery. 1999;57(10):1195–1200.2
Watcha MF, Bras PJ, Cieslak GD, Pennant JH. The dose-response relationship of ondansetron in preventing postoperative emesis in pediatric patients undergoing ambulatory surgery. Anesthesiology. 1995;82(1):47–52.2
White LA, Vanarase M, Brockbank K, Barrett RF. Patient-controlled analgesia and postoperative nausea and vomiting: Efficacy of a continuous infusion of ondansetron. Anaesthesia. 2001;56(4):365–369.2
Yazigi A, Chalhoub V, Madi-Jebara S, Haddad F, Hayek G. Prophylactic ondansetron is effective in the treatment of nausea and vomiting but not on pruritus after cesarean delivery with intrathecal sufentanil-morphine. Journal of Clinical Anesthesia. 2002;14(3):183–186.2
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Observational studies
Aapro M, Bourke JP. Rapid intravenous administration of granisetron prior to chemotherapy is not arythmogenic: Results of a pilot study. European Journal of Cancer. 2003;39(7):927–931.2
Baltzer L, Kris MG, Tyson LB, Rigas JR, Pisters KMW. The addition of ondansetron to the combination of metoclopramide, dexamethasone, and lorazepam did not improve vomiting prevention in patients receiving high-dose cisplatin. Cancer. 1994;73(3):720–723.2
Belkacemi Y, Ozsahin M, Pene F, et al. Total body irradiation prior to bone marrow transplantation: efficacy and safety of granisetron in the prophylaxis and control of radiation-induced emesis. International Journal of Radiation Oncology, Biology, Physics. 1996;36(1):77–82.2
Belle SV, Cocquyt V, Smet MD, et al. Comparison of a neurokinin-1 antagonist, L-758,298 {aprepitant}, to ondansetron in the prevention of cisplatin-induced emesis. Proc Annu Meet Am Soc Clin Oncol. Abstract # 198p. 1998.5
Bernstein BJ, Ong C. Efficacy of a single 8-mg i.v. dose of ondansetron hydrochloride for preventing chemotherapy-induced emesis. American Journal of Health-System Pharmacy. 2002;59(7):650–652.2
Berry WR, House KW, Lee JT, Plagge PB, Meshad MW, Grapski R. Results of a compassionate-use program using intravenous ondansetron to prevent nausea and vomiting in patients receiving emetogenic cancer chemotherapy. Seminars in Oncology. 1992;19(6 SUPPL. 15):33–37.2
Blijham GH. Does granisetron remain effective over multiple cycles? European Journal of Cancer Part A: General Topics. 1992;28(SUPPL. 1):S 17-S 21.2
Braken JB, Raemaekers JMM, Koopmans PP, De Pauw BE. Control of nausea and vomiting with ondansetron in patients treated with intensive non-cisplatin chemotherapy for acute myeloid leukaemia. European Journal of Cancer Part A: General Topics. 1993;29(4):515–518.2
Campora E, Oliva C, Mammoliti S, et al. Oral ondansetron (GR 38032F) for the control of CMF-induced emesis in the outpatient. Breast Cancer Research and Treatment. 1991;19(2):129–132.2
Campora E, Vidili G, Oliva C, Ardizzoni A, Rosso R. Control of refractory, chemotherapy-induced emesis with the serotonin antagonist ondansetron (GR38032F). Oncology. 1991;48(5):403–405.2
Carden PA, Mitchell SL, Waters KD, Tiedemann K, Ekert H. Prevention of cyclophosphamide/cytarabine-induced emesis with ondansetron in children with leukemia. Journal of Clinical Oncology. 1990;8(9):1531–1535.2
Carmichael J, Harris AL. High-dose i.v. granisetron for the prevention of chemotherapy-induced emesis: Cardiac safety and tolerability. Anti-Cancer Drugs. 2003;14(9):739–744.2
Carmichael J, Harris AL. The cardiovascular safety of high-dose intravenous granisetron in cancer patients receiving highly emetogenic chemotherapy. Cancer Chemotherapy and Pharmacology. 2004;53(2):123–128.2
Carmichael J, Keizer HJ, Cupissol D, Milliez J, Scheidel P, Schindler AE. Use of granisetron in patients refractory to previous treatment with antiemetics. Anti-Cancer Drugs. 1998;9(5):381–385.2
Casper J, Casper S, Kohne-Wompner CH, Bokemeyer C, Hecker H, Schmoll - HJ. 5-HT3 antagonist ondansetron for the treatment of chemotherapy induced nausea and vomiting in an outpatient population. International Journal of Oncology. 1994;4(6):1283–1289.2
Coates AS, Childs A, Cox K, et al. Severe vascular adverse effects with thrombocytopenia and renal failure following emetogenic chemotherapy and ondansetron. Annals of Oncology. 1992;3(9):719–722.2
Cohen IJ, Zehavi N, Buchwald I, et al. Oral ondansetron: An effective ambulatory complement to intravenous ondansetron in the control of chemotherapy-induced nausea and vomiting in children. Pediatric Hematology and Oncology. 1995;12(1):67–72.2
Conroy T, Cappelaere P, Fabbro M, et al. Acute antiemetic efficacy and safety of dolasetron mesylate, a 5-HT3 antagonist, in cancer patients treated with cisplatin. American Journal of Clinical Oncology: Cancer Clinical Trials. 1994;17(2):97–102.2
Currow DC, Coughlan M, Fardell B, Cooney NJ. Use of ondansetron in palliative medicine. Journal of Pain and Symptom Management. 1997;13(5):302–307.2
De Wet M, Falkson G, Rapoport BL. Repeated use of granisetron in patients receiving cytostatic agents. Cancer. 1993;71(12):4043–4049.2
Einhorn LH, Nagy C, Werner K, Finn AL. Ondansetron: a new antiemetic for patients receiving cisplatin chemotherapy. J Clin Oncol. Apr 1990;8(4):731–735.2
Eisenberg P, MacKintosh FR, Ritch P, Cornett PA, Macciocchi A. Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: A dose-ranging clinical study. Annals of Oncology. 2004;15(2):330–337.2
Farley PA, Dempsey CL, Shillington AA, Kulis-Robitaille C, Colgan K, Bernstein G. Patients' self-reported functional status after granisetron or ondansetron therapy to prevent chemotherapy-induced nausea and vomiting at six cancer centers. American Journal of Health-System Pharmacy. 1997;54(21):2478–2482.2
Fauser AA, Russ W, Bischoff M. Oral dolasetron mesilate (MDL 73,147EF) for the control of emesis during fractionated total-body irradiation and high-dose cyclophosphamide in patients undergoing allogeneic bone marrow transplantation. Supportive Care in Cancer. 1997;5(3):219–222.2
Framarino dei Malatesta M, Veneziano M, Fiorelli C, et al. Ondansetron in chemotherapy-induced emesis - Our experience. European Journal of Gynaecological Oncology. 1995;16(2):97–106.2
Franchi M, Donadello N, Zanaboni F, Tusei A, Scorbati E. Oral ondansetron and intravenous dexamethasone in the prevention of cisplatin-induced emesis. A phase II trial in women. Oncology. 1995;52(6):509–512.2
Gebbia V, Testa A, Valenza R, Gebbia N, Rausa L. Prophylaxis of cytotoxic chemotherapy induced emesis with the 5HT-3 receptor inhibitor ondansetron. International Journal of Experimental and Clinical Chemotherapy. 1992;5(3):181–184.2
Gratz I, Allen E, Afshar M, Joslyn AF, Buxbaum J, Prilliman B. The effects of the menstrual cycle on the incidence of emesis and efficacy of ondansetron. Anesthesia and Analgesia. 1996;83(3):565–569.6
Grote TH, Pineda LF, Figlin RA, et al. Oral dolasetron mesylate in patients receiving moderately emetogenic platinum-containing chemotherapy. Cancer Journal from Scientific American. 1997;3(1):45–51.6
Harvey VJ, Evans BD, Mitchell PLR, et al. Reduction of carboplatin induced emesis by ondansetron. British Journal of Cancer. 1991;63(6):942–944.2
Henriksson R, Lomberg H, Israelsson G, Zackrisson B, Franzen L. The effect of ondansetron on radiation-induced emesis and diarrhoea. Acta Oncologica. 1992;31(7):767–769.2
Hesketh PJ, Gandara DR, Hesketh AM, et al. Dose-ranging evaluation of the antiemetic efficacy of intravenous dolasetron in patients receiving chemotherapy with doxorubicin or cyclophosphamide. Supportive Care in Cancer. 1996;4(2):141–146.2
Hewitt M, Cornish J, Pamphilon D, Oakhill A. Effective emetic control during conditioning of children for bone marrow transplantation using ondansetron, a 5-HT3 antagonist. Bone Marrow Transplantation. 1991;7(6):431–433.2
Honkavaara P, Pyykko I, Rutanen EM. Increased incidence of retching and vomiting during periovulatory phase after middle ear surgery. Canadian Journal of Anaesthesia. 1996;43(11):1108–1114.2
Hunter AE, Prentice HG, Pothecary K, et al. Granisetron, a selective 5-HT3 receptor antagonist, for the prevention of radiation induced emesis during total body irradiation. Bone Marrow Transplantation. 1991;7(6):439–441.6
Jacobson SJ, Shore RW, Greenberg M, Spielberg SP. The efficacy and safety of granisetron in pediatric cancer patients who had failed standard antiemetic therapy during anticancer chemotherapy. American Journal of Pediatric Hematology/Oncology. 1994;16(3):231–235.2
Jantunen IT, Kataja VV, Uhonen TT, Parviainen T. Effects of granisetron with doxorubicin or epirubicin on ECG intervals. Cancer Chemotherapy and Pharmacology. 1996;37(5):502–504.2
Jichang Z, Binghe X, Aiping Z. Phase III clinical studies with ondansetron (Qilu) in the prophylaxis of nausea and vomiting induced by non-cisplatin chemotherapy. Chinese Journal of Oncology. 1997;19(6):460–462.1
Jurgens H, McQuade B. Ondansetron as prophylaxis for chemotherapy and radiotherapy-induced emesis in children. Oncology. 1992;49(4):279–285.6
Kris MG. Phase II trials of ondansetron with high-dose cisplatin. Seminars in Oncology. 1992;19(4 SUPPL. 10):23–27.2
Kris MG, Clark RA, Tyson LB, Hahne WF, Pisters KMW, Gralla RJ. Phase II trial of a single intravenous dose of ondansetron in patients receiving cisplatin (greater-than or equal to) 100 mg/m2. American Journal of Clinical Oncology: Cancer Clinical Trials. 1993;16(1):77–80.2
Kris MG, Grunberg SM, Gralla RJ, et al. Dose-ranging evaluation of the serotonin antagonist dolasetron mesylate in patients receiving high-dose cisplatin. Journal of Clinical Oncology. 1994;12(5):1045–1049.2
Lemerle J, Amaral D, Southall DP, Upward J, Murdoch RD. Efficacy and safety of granisetron in the prevention of chemotherapy-induced emesis in paediatric patients. European Journal of Cancer. 1991;27(9):1081–1083.2
Lippens RJJ, Broeders GCJM. Ondansetron in radiation therapy of brain tumor in children. Pediatric Hematology and Oncology. 1996;13(3):247–252.2
Martin AR, Carides AD, Pearson JD, et al. Functional relevance of antiemetic control. Experience using the FLIE questionnaire in a randomised study of the NK-1 antagonist aprepitant. European Journal of Cancer. 2003;39(10):1395–1401.2
Martini F, Milandri C, Turci P, Gentilini P. Vascular complications in patients receiving chemotherapy: What role do third generation antiemetics play? Oncology Reports. 1995;2(4):553–555.2
McQueen KD, Milton JD. Multicenter postmarketing surveillance of ondansetron therapy in pediatric patients. Annals of Pharmacotherapy. 1994;28(1):85–92.2
Merrouche Y, Catimel G, Rebattu P, et al. A phase I antiemetic study of MDL 73,147EF, a novel 5-hydroxytryptamine antagonist in cancer patients receiving emetogenic chemotherapy. Annals of Oncology. 1994;5(6):549–551.2
Parikh PM, Shah SR, Shah SC, et al. Preliminary experience with use of a selective 5HT3 receptor antagonist (ondansetron) to prevent high dose chemotherapy induced emesis. Indian Journal of Cancer. 1996;33(1):17–20.2
Peters II MD, Long KS, Patel HS, Reitz JA, Jessen LM, Emhart GC. Multicenter evaluation of ondansetron use in hospitalized oncology patients. American Journal of Hospital Pharmacy. 1993;50(6):1164–1170.2
Roberts JT. Ondansetron in the control of refractory emesis following radiotherapy. Clin Oncol (R Coll Radiol). Jan 1992;4(1):67–68.2
Roila F, Bracarda S, Tonato M, et al. Ondansetron (GR38032) in the prophylaxis of acute and delayed cisplatin-induced emesis. Clin Oncol (R Coll Radiol). Sep 1990;2(5):268–272.2
Rosso R, Campora E, Cetto G, Fosser V, Marangolo M, Oliva C. Oral ondansetron (GR 38032F) for the control of acute and delayed cyclophosphamide-induced emesis. Anticancer Research. 1991;11(2):937–939.2
Schwella N, Konig V, Schwerdtfeger R, et al. Ondansetron for efficient emesis control during total body irradiation. Bone Marrow Transplantation. 1994;13(2):169–171.2
Seynaeve C, de Mulder PH, Lane-Allman E, van Liessum PA, Verweij J. The 5-HT3 receptor antagonist ondansetron re-establishes control in refractory emesis induced by non-cisplatin chemotherapy. Clinical Oncology (Royal College of Radiologists). 1991;3(4):199–203.2
Smith DB, Newlands ES, Rustin GJS, et al. A phase I/II study of the 5-HT3 antagonist GR38032F in the anti-emetic prophylaxis of patients receiving high-dose cisplatin chemotherapy. Cancer Chemotherapy and Pharmacology. 1990;25(4):291–294.2
Smith DB, Rustin GJ, Howells N, Lambert HE, McQuade B. A phase II study of ondansetron as antiemetic prophylaxis in patients receiving carboplatin for advanced ovarian cancer. The North Thames Ovary Group. Ann Oncol. Sep 1991;2(8):607–608.2
Sohara N, Takagi H, Abe T, et al. Nausea and vomiting induced by arterial chemo-embolization in patients with hepatocellular carcinoma and the antiemetic effect of ondansetron hydrochloride. Supportive Care in Cancer. 1999;7(2):84–88.2
Steiner M, Yorgason RZ, Vermeulen LC, Theisen J. Patient outcomes after therapeutic interchange of dolasetron for granisetron. American Journal of Health-System Pharmacy. 2003;60(10):1023–1028.2
Stoltz R, Cyong J-C, Shah A, Parisi S. Pharmacokinetic and Safety Evaluation of Palonosetron, a 5-Hydroxytryptamine-3 Receptor Antagonist, in U.S. and Japanese Healthy Subjects. Journal of Clinical Pharmacology. 2004;44(5):520–531.4
Togo S, Akiyama H, Yamaguchi S, Ichikawa Y, Ike H, Shimada H. Clinical evaluation of granisetron as an inhibitor of nausea and vomiting induced by oral anticancer drugs. Oncology Reports. 2002;9(2):277–282.2
Tolan MM, Fuhrman TM, Tsueda K, Lippmann SB. Perioperative extrapyramidal reactions associated with ondansetron. Anesthesiology. 1999;90(1):340–341.6
Tzekova VI, Velikova MT, Koynov KD. Granisetron in repeated cycles of chemotherapy with platinum. Neoplasma. 1998;45(1):46–49.2
Veneziano M, Framarino dei Malatesta M, Bandiera AF, Fiorelli C, Galati M, Paolucci A. Ondansetron-induced headache Our experience in gynecological cancer. European Journal of Gynaecological Oncology. 1995;16(3):203–207.2
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Witherow P, Wilson K. Using ondansetron with pediatric patients undergoing total body irradiation. Oncol Nurs Forum. Nov–Dec 1991;18(8):1416–1417.5
Systematic Reviews
Antonarakis ES, Evans JL, Heard GF, Noonan LM, Pizer BL, Hain RDW. Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence? Pediatric Blood and Cancer. 2004;43(6):651–658.8
Aspinall RL, Goodman NW. Denial of effective treatment and poor quality of clinical information in placebo controlled trials of ondansetron for postoperative nausea and vomiting: A review of published trials. British Medical Journal. 1995;311(7009):844–846.8
Carlisle J, Schousboe BMB, Moller A, Pedersen T. Drugs for preventing postoperative nausea and vomiting. Cochrane Database of Systematic Reviews. 2004;4.2
Constenla M. 5-HT3 receptor antagonists for prevention of late acute-onset emesis. Annals of Pharmacotherapy. 2004;38(10):1683–1691.8
Cox F. Systematic review of ondansetron for the prevention and treatment of postoperative nausea and vomiting in adults. British Journal of Theatre Nursing. 1999;9(12):556–566.8
Del Giglio A, Soares HP, Caparroz C, Castro PC. Granisetron is equivalent to ondansetron for prophylaxis of chemotherapy-induced nausea and vomiting: Results of a meta-analysis of randomized controlled trials. Cancer. 2000;89(11):2301–2308.8
Figueredo ED, Canosa LG. Ondansetron in the prophylaxis of postoperative vomiting: A meta-analysis. Journal of Clinical Anesthesia. 1998;10(3):211–221.8
Jewell D, Young G, Hall PF. Review: Antiemetic drugs reduce nausea in early pregnancy. Evidence-Based Medicine. 2002;7:155%N 155.5
Kazemi-Kjellberg F, Henzi I, Tramer MR. Treatment of established postoperative nausea and vomiting: A quantitative systematic review. BMC Anesthesiology. 2001;1(−).8
Laplanche A, Gerondeau N. Role of ondansetron in cancerology PLACE DE L'ONDANSETRON EN CANCEROLOGIE. Bulletin du Cancer. 1993;80(7):568–576.”1
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Smith E, Wasiak J, Boyle M. Prophylactic antiemetic therapy in the emergency and ambulance setting for preventing opioid induced nausea and vomiting. Cochrane Database of Systematic Reviews. 2004;4.4
Tramer MR, Moore RA, Reynolds DJM, McQuay HJ. A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting. British Medical Journal. 1997;314(7087):1088–1092.2
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Excluded Studies: Update 1

Excluded studiesExclusion code #
Head-to-head trial
Buyukavci M, Olgun H, Ceviz N. The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia. American Journal of Clinical Oncology. Apr 2005;28(2):201–204.2
Active Control trials
Bolton CM, Myles PS, Carlin JB, Nolan T. Randomized, double-blind study comparing the efficacy of moderate-dose metoclopramide and ondansetron for the prophylactic control of postoperative vomiting in children after tonsillectomy. British Journal of Anaesthesia. Nov 2007;99(5):699–703.2
Boonmak P, Boonmak S, Bunsaengjaroen P, Srichaipanha S, Poomsawat S, Nonlhaopol D. Antiemetic effect of ondansetron 0.2 mg mL-1 in PCA morphine solution. European Journal of Anaesthesiology. 2007;24(8):664–667.6
Khamales S, Bethune-Volters A, Chidiac J, Bensaoula O, Delgado A, Di Palma M. A randomized, double-blind trial assessing the efficacy and safety of sublingual metopimazine and ondansetron in the prophylaxis of chemotherapy-induced delayed emesis.[erratum appears in Anticancer Drugs. 2006 Jun; 17(5):599 Note: Khamales, Slimane]. Anti-Cancer Drugs. Feb 2006;17(2):217–224.3
Lee Y, Wang PK, Lai HY, Yang YL, Chu CC, Wang JJ. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Canadian Journal of Anaesthesia. May 2007;54(5):349–354.2
Luisi FA, Petrilli AS, Tanaka C, Caran EM. Contribution to the treatment of nausea and emesis induced by chemotherapy in children and adolescents with osteosarcoma. Sao Paulo Medical Journal = Revista Paulista de Medicina. 2006;124(2):61–65.2
Peixoto AJ, Celich MF, Zardo L, Peixoto Filho AJ. Ondansetron or droperidol for prophylaxis of nausea and vomiting after intrathecal morphine. European Journal of Anaesthesiology. Aug 2006;23(8):670–675.4
Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesthesia & Analgesia. of contents, 2008 May 2008;106(5):1407–1409.2
Sarvela PJ, Halonen PM, Soikkeli AI, Kainu JP, Korttila KT. Ondansetron and tropisetron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective cesarean delivery. Acta Anaesthesiologica Scandinavica. Feb 2006;50(2):239–244.2
Teran L, Hawkins JK. The effectiveness of inhalation isopropyl alcohol vs granisetron for the prevention of postoperative nausea and vomiting. AANA Journal. Dec 2007;75(6):417–422.2
Placebo-controlled trials
Bano F, Zafar S, Aftab S, Haider S. Dexamethasone plus ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a comparison with dexamethasone alone. Jcpsp, Journal of the College of Physicians & Surgeons - Pakistan. May 2008;18(5):265–269.3
Cohen IT, Joffe D, Hummer K, Soluri A. Ondansetron oral disintegrating tablets: acceptability and efficacy in children undergoing adenotonsillectomy. Anesthesia & Analgesia. of contents, 2005 Jul 2005;101(1):59–63.2
D'Angelo R, Philip B, Gan TJ, et al. A randomized, double-blind, close-ranging, pilot study of intravenous granisetron in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy. European Journal of Anaesthesiology. Oct 2005;22(10):774–779.2
Davis PJ, Fertal KM, Boretsky KR, et al. The effects of oral ondansetron disintegrating tablets for prevention of at-home emesis in pediatric patients after ear-nose-throat surgery. Anesthesia & Analgesia. of contents, 2008 Apr 2008;106(4):1117–1121.2
Freedman SB, Adler M, Seshadri R, Powell EC. Oral ondansetron for gastroenteritis in a pediatric emergency department. New England Journal of Medicine. Apr 20 2006;354(16):1698–1705.4
Hartsell T, Long D, Kirsch JR. The efficacy of postoperative ondansetron (Zofran) orally disintegrating tablets for preventing nausea and vomiting after acoustic neuroma surgery. Anesthesia & Analgesia. Nov 2005;101(5):1492–1496.2
Jellish WS, Leonetti JP, Sawicki K, Anderson D, Origitano TC. Morphine/ondansetron PCA for postoperative pain, nausea, and vomiting after skull base surgery. Otolaryngology - Head & Neck Surgery. Aug 2006;135(2):175–181.4
Khalil SN, Roth AG, Cohen IT, et al. A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia. Anesthesia & Analgesia. of contents, 2005 Aug 2005;101(2):356–361.2
Kocamanoglu IS, Baris S, Karakaya D, Sener B, Tur A, Cetinkaya M. Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. Methods & Findings in Experimental & Clinical Pharmacology. Sep 2005;27(7):489–493.2
Kovac AL, Eberhart L, Kotarski J, Clerici G, Apfel C, Palonosetron 04–07 Study G. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesthesia & Analgesia. Aug 2008;107(2):439–444.2
Subramaniam K, Pandia MP, Dash M, et al. Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children. European Journal of Anaesthesiology. 2007;24(7):615–619.2
Observational studies
Arole A, Kroll HR, Brown M. Coronary vasospasm leading to an acute myocardial infarction after the administration of dolasetron. Journal of Clinical Anesthesia. Feb 2005;17(1):72–74.6
Einhorn LH, Brames, M.J., Dreicer, R., Nichols, C.R., Cullen, M.T. Jr., Bubalo, J. Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea adn vomiting in patients receiving multiple- day cisplatin chemotherapy for germ cell cancer. Supportive care in cancer 2007;15(11):1293–1300.6
Hasler SB, Hirt A, Ridolfi Luethy A, Leibundgut KK, Ammann RA. Safety of ondansetron loading doses in children with cancer. Supportive Care in Cancer. May 2008;16(5):469–475.2
Navari RM, Einhorn LH, Loehrer PJ, al. e. A phase II trial of olanzapine and palonosetron for the prevention of chemotherapy induced nausea and vomiting: a Hoosier oncology group study. . Support Care Cancer. 2007;15(11):1285–1291.3
Piwko C, Lasry A, Alanezi K, Coyte PC, Ungar WJ. Economic evaluation of ondansetron vs dimenhydrinate for prevention of postoperative vomiting in children undergoing strabismus surgery. Paediatric Anaesthesia. Sep 2005;15(9):755–761.2
Siu SS, Chan MT, Lau TK. Placental transfer of ondansetron during early human pregnancy. Clinical Pharmacokinetics. 2006;45(4):419–423.3
Systematic reviews
Alhashimi, Alhashimi, Fedorowicz. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents [Systematic Review]. Cochrane Database of Systematic Reviews. 2008;1:1.4
Carlisle, Jb, Stevenson, Ca. Drugs for preventing postoperative nausea and vomiting [Systematic Review]. Cochrane Database of Systematic Reviews. 2008;1:1.3
Figueredo E, Canosa L. Prophylactic ondansetron for postoperative emesis. Meta-analysis of its effectiveness in patients with previous history of postoperative nausea and vomiting. Acta Anaesthesiologica Scandinavica. 1999;43(6):637–644.6
Gupta A, Wu CL, Elkassabany N, Krug CE, Parker SD, Fleisher LA. Does the routine prophylactic use of antiemetics affect the incidence of postdischarge nausea and vomiting following ambulatory surgery?: A systematic review of randomized controlled trials. Anesthesiology. 2003;99(2):488–495.6
Huang JQ, Zheng GF, Chan GC, Karlberg J, Lam SK, Wong BC. Efficacy of current antietmetic treatment for preventing delayed chemotherapy-induced nausea and vomiting: a meta-analysis of randomized controlled trials. Clinical Research and Regulatory Affairs. 2004;21(3–4):191–212.6
Neufeld SM, Newburn-Cook CV. The efficacy of 5-HT3 receptor antagonists for the prevention of postoperative nausea and vomiting after craniotomy: a meta-analysis. Journal of Neurosurgical Anesthesiology. 2007;19(1):10–17.6
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK47163

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