Table 41Intake of various types of fat and risk of cognitive decline

StudySample (n)FollowupExposureCase definitionConfounding adjustmentResults
Morris et al., 2004252Community cohort (2560)5.6 yearsEstimates of total intake of various types of fat during the previous year were calculated from self-report responses on a modified Harvard food frequency questionnaireCognitive decline on standardized composite measure from all testsAge
Race
Sex
Educational level
Total energy from calories
Smoking
Alcohol use
Time between assessments
HTN
Vitamin C
Vitamin E
Higher intake of saturated fat (trend p = 0.04) and trans-unsaturated fat (trend p = 0.07) were linearly associated with greater decline in cognitive score over 6 years. When excluding individuals who changed pattern of fat intake in last 10 years and/or those scoring in lowest 15%, effect became stronger.

Total fat, vegetable and animal fat, and cholesterol not associated with cognitive change

Abbreviation: HTN = hypertension

From: 3, Results

Cover of Preventing Alzheimer's Disease and Cognitive Decline
Preventing Alzheimer's Disease and Cognitive Decline.
Evidence Reports/Technology Assessments, No. 193.
Williams JW, Plassman BL, Burke J, et al.

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