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Last Update: July 18, 2022.

Continuing Education Activity

Hyperuricemia is a common disorder that affects patients of all ages and genders. The most common manifestation of hyperuricemia is gout, which can be very painful and is easily treatable. This activity reviews the pathophysiology, presentation, evaluation, and treatment of hyperuricemia, and highlights the role of the interprofessional team in caring for affected patients.


  • Explain the pathophysiology of hyperuricemia.
  • Describe typical history and physical exam findings in a patient with hyperuricemia.
  • Identify treatment modalities for both acute and chronic hyperuricemia.
  • Describe the importance of improving patient care coordination amongst interprofessional care teams to improve the long-term outcomes for patients with hyperuricemia.
Access free multiple choice questions on this topic.


Hyperuricemia is an elevated uric acid level in the blood. The normal upper limit is 6.8mg/dL, and anything over 7 mg/dL is considered saturated, and symptoms can occur.

This elevated level is the result of increased production, decreased excretion of uric acid, or a combination of both processes.  

Elevated uric acid can also be seen in accelerated purine degradation, in high cell turnover states (hemolysis, rhabdomyolysis, and tumor lysis) and decreased excretion (renal insufficiency and metabolic acidosis). Hyperuricemia can lead to gout and nephrolithiasis. It has also been implicated as an indicator for diseases like metabolic syndrome, diabetes mellitus, cardiovascular disease, and chronic renal disease.[1]


Urate Overproduction

  • Purine rich diet
  • Error of purine metabolism: hypoxanthine phosphoribosyltransferase (HPRT) deficiency, phosphoribosylpyrophosphate (PRPP) synthetase over activity
  • Cell breakdown or turnover: lymphoproliferative diseases, myeloproliferative disease, polycythemia vera, Paget disease, psoriasis, tumor lysis, hemolysis, rhabdomyolysis, exercise

Decreased Uric acid Excretion 

  • Acute or chronic kidney disease, acidosis (lactic acidosis, ketoacidosis), hypovolemia, medication/toxin (diuretic, niacin, pyrazinamide, ethambutol, cyclosporin, beryllium, salicylates, lead, alcohol), sarcoidosis, hyperparathyroidism, hypothyroidism, Bartter syndrome, Down syndrome[2]


It is estimated as much as 21% of the general population and 25% of hospitalized patients have asymptomatic hyperuricemia. The most common complication of hyperuricemia is gout which is seen in 3.9% of the U.S. population. Hyperuricemia does not in itself indicate a pathological state because it is very prevalent in the general population.


Uric acid (2,6,8 trioxypurine-C5H4N4O3) is the result of purine breakdown. At the normal physiological pH of 7.4, uric acid circulates in the ionized form of urate. Purine metabolism mainly occurs in the liver, but it can also be produced in any other tissue that contains xanthine oxidase (intestines). About two-thirds of uric acid is excreted in the kidneys, and a third is excreted into the intestine. In the kidneys, it is filtered and secreted, and 90% is reabsorbed. Other mammals have lower uric acid levels due to the activity of uricase. This enzyme converts urate to the more water soluble form of allantoin.[3]

Urate production is accelerated by purine rich diets, endogenous purine production, and high cell breakdown, and it is responsible for a minority of cases of hyperuricemia. Foods rich in purine include all meats but specifically organ meats (kidneys, liver, “sweet bread”), game meats and some seafood (anchovies, herring, scallops). Beer, which is purine rich, also increases uric acid levels by decreasing kidney excretion. Endogenous production of the purine production can be accelerated by phosphoribosylpyrophosphate (PRPP) synthetase activity as well as a defect in the regulatory enzyme hypoxanthine phosphoribosyltransferase (HPRT). Conditions of accelerated cell breakdown or turnover such as rhabdomyolysis, hemolysis, and tumor lysis can also be a purine source and thus, increase urate production.

Urate excretion occurs primarily in the kidneys and is responsible for hyperuricemia in 90% of individuals. Underexcretion appears to be a combination of decreased glomerular filtration, decreased tubular secretion, and enhanced tubular reabsorption. The acute or chronic decrease in glomerular filtration can result in hyperuricemia. Proximal tubular reabsorption of uric acid is controlled by URAT1 (uric acid transporter 1). This transported can be stimulated by organic acids (lactate and acetoacetate, and beta-hydroxybutyrate), medications (niacin, pyrazinamide, ethambutol, cyclosporin, and chemotherapy) and reduced extracellular fluid volume resulting in hyperuricemia.[1]

History and Physical

Clinical Manifestations

Gout is a metabolic disorder that allows for the accumulation of uric acid in the blood and tissues. This leads to the precipitation of urate monohydrate crystals within a joint. When tissues are saturated with urate, crystals will precipitate. Precipitation is enhanced in acidic environments and cold environments, leading to increased precipitation in peripheral joints, such as the great toe. Gout has a male predominance in a 4:1 ratio of men to women. Uric acid levels can be elevated ten to 15 years before clinical manifestations of gout.[4]

In uric acid nephrolithiasis, uric acid is handled by the renal system, and three factors can influence uric acid stone formation. These factors are TH acidic urine, dehydration, and hyperuricosuria. Persistent acidic urine is the most common cause of uric acid stone formation. Hyperuricosuria is defined as uric acid levels that exceed 800 mg/day in men and 750 mg/day in women. It is most commonly associated with increased dietary intake. Uric acid stones are 5% to 10% of all urinary stones.[5]


Hyperuricemia does not represent a disease or a specific indication for therapy. The majority of patients with elevated uric acid are asymptomatic and require no long term therapy.  The patient may give a history of a purine rich diet or alcohol consumption, specifically beer. Past medical history, as well as current medications, should be reviewed to find a correlation with poor renal excretion of urate or increased production.

The two most common complaints associated with hyperuricemia are gout and uric acid nephrolithiasis.  

With gout, a patient will complain of red hot swollen joint, most commonly in the big toe.

With nephrolithiasis, patients will complain of flank pain, hematuria, nausea/vomiting, and colicky pain.

Physical Exam

There will be no specific physical exam finding that will indicate hyperuricemia unless the patient is presenting with complaints of gout or nephrolithiasis.

With gout, there is evidence of an erythematous, warm, and swollen joint. Most commonly affects the big toe, but can affect any joint in the body. Usually, gout affects one joint at a time.

Nephrolithiasis has no specific physical exam findings but may have costovertebral angle tenderness. Look for hematuria on urinalysis.


Lab studies will most likely reveal the following:

Serum uric acid: normal is less than 6.8 mg/dL

Twenty-four--hour urine uric acid collection should be less than 600 mg/day for an adult male on a purine free diet. A level above this implies elevated uric acid production.

Consider complete blood count (CBC), CMP, lipid profile, calcium and phosphate levels. These laboratory studies are to assess for underlying disease leading to elevated uric acid but are adjunct studies.

Consider joint x-rays to evaluate joint swelling; however, x-rays are not necessary for the diagnosis of gout.

Renal ultrasounds are indicated in patients with uric acid nephrolithiasis.


Consider joint aspiration to evaluate for uric acid crystals, look for negatively birefringent under polarized microscopy.

Routine screening for hyperuricemia is not recommended.[3]

Treatment / Management

The majority of patients are asymptomatic and do not need medical therapy for hyperuricemia as they will never develop gout or nephrolithiasis. The unnecessary cost of medication and potential for adverse effects outweighs the benefit of starting medication. Urate lowering medications in asymptomatic patients are only indicated in those undergoing cytolytic therapy for malignancy to prevent tumor lysis syndrome.[6][7][8][9]

Urate-lowering medications:

  • Allopurinol: xanthine oxidase inhibitors; used as prophylaxis against gouty arthritis, nephrolithiasis, and chemo related hyperuricemia
  • Probenecid: inhibits URAT1 result in increased uric acid secretion and used as second-line therapy for gout
  • Rasburicase: recombinant uricase that converts uric acid to allantoin which is much more water soluble and readily excreted from the kidneys and used as prophylaxis against chemo-related hyperuricemia[3]

Differential Diagnosis

  • Alcoholic ketoacidosis
  • Diabetic ketoacidosis
  • Gout and pseudogout
  • Hemolytic anaemia
  • Hodgkin lymphoma
  • Hyperparathyroidism
  • Hypothyroidism
  • Nephrolithiasis
  • Preeclampsia
  • Type 1a glycogen storage disease

Enhancing Healthcare Team Outcomes

Because there are many causes of hyperuricemia, the condition is best managed by an interprofessional team that includes an internist, primary care provider, nurse practitioner, endocrinologist, a rheumatologist and an oncologist. The majority of patients are asymptomatic and do not need medical therapy for hyperuricemia as they will never develop gout or nephrolithiasis. The unnecessary cost of medication and potential for adverse effects outweighs the benefit of starting medication. Urate-lowering medications in asymptomatic patients are only indicated in those undergoing cytolytic therapy for malignancy to prevent tumor lysis syndrome. [10][11]

The outlook for benign causes of hyperuricemia is good but those with a malignancy may develop complications like gout or renal stones. The majority of these patients need close monitoring to determine if the condition is improving with treatment.[12]

Review Questions


Barkas F, Elisaf M, Liberopoulos E, Kalaitzidis R, Liamis G. Uric acid and incident chronic kidney disease in dyslipidemic individuals. Curr Med Res Opin. 2018 Jul;34(7):1193-1199. [PubMed: 28836857]
Dong H, Xu Y, Zhang X, Tian S. Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes. Sci Rep. 2017 Aug 18;7(1):8822. [PMC free article: PMC5562916] [PubMed: 28821853]
Yakupova SP. Gout. New opportunities of diagnosis and treatment. Ter Arkh. 2018 May 11;90(5):88-92. [PubMed: 30701896]
Williams LA. The History, Symptoms, Causes, Risk Factors, Types, Diagnosis, Treatments, and Prevention of Gout, Part 2. Int J Pharm Compd. 2019 Jan-Feb;23(1):14-21. [PubMed: 30668531]
Paquot N, Scheen AJ. [DPP-4 or SGLT2 inhibitor added to metformin alone in type 2 diabetes]. Rev Med Suisse. 2017 Aug 23;13(571):1410-1415. [PubMed: 28837277]
Yang N, Yu Y, Zhang A, Estill J, Wang X, Zheng M, Zhou Q, Zhang J, Luo X, Qian C, Mao Y, Wang Q, Yang Y, Chen Y. Reporting, presentation and wording of recommendations in clinical practice guideline for gout: a systematic analysis. BMJ Open. 2019 Jan 29;9(1):e024315. [PMC free article: PMC6352818] [PubMed: 30700479]
Alqarni NA, Hassan AH. Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia. Saudi Med J. 2018 Dec;39(12):1218-1225. [PMC free article: PMC6344656] [PubMed: 30520504]
Engel B, Schacher S, Weckbecker K, Stausberg A, Gräff I. [Acute Gout in Emergency Admissions - Patient Characteristics and Adherence of Care Processes to Current Guidelines]. Z Orthop Unfall. 2018 Dec;156(6):653-661. [PubMed: 29986356]
Buzas R, Tautu OF, Dorobantu M, Ivan V, Lighezan D. Serum uric acid and arterial hypertension-Data from Sephar III survey. PLoS One. 2018;13(7):e0199865. [PMC free article: PMC6028095] [PubMed: 29966019]
Yu KH, Chen DY, Chen JH, Chen SY, Chen SM, Cheng TT, Hsieh SC, Hsieh TY, Hsu PF, Kuo CF, Kuo MC, Lam HC, Lee IT, Liang TH, Lin HY, Lin SC, Tsai WP, Tsay GJ, Wei JC, Yang CH, Tsai WC. Management of gout and hyperuricemia: Multidisciplinary consensus in Taiwan. Int J Rheum Dis. 2018 Apr;21(4):772-787. [PubMed: 29363262]
Janssen CA, Jansen TLTA, Oude Voshaar MAH, Vonkeman HE, van de Laar MAFJ. Quality of care in gout: a clinical audit on treating to the target with urate lowering therapy in real-world gout patients. Rheumatol Int. 2017 Sep;37(9):1435-1440. [PMC free article: PMC5570767] [PubMed: 28748426]
Huang G, Qin J, Deng X, Luo G, Yu D, Zhang M, Zhou S, Wang L. Prognostic value of serum uric acid in patients with acute heart failure: A meta-analysis. Medicine (Baltimore). 2019 Feb;98(8):e14525. [PMC free article: PMC6408052] [PubMed: 30813158]
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