FIGURE 4-2. Integron mechanism of gene capture.

FIGURE 4-2Integron mechanism of gene capture

Integron-mediated gene capture and the model for cassette exchange. Outline of the process by which circular antibiotic resistance gene cassettes (antR) are repeatedly inserted at the specific attI site in a class 1 integron downstream of the strong promoter Pc.intl1, integrase-encoding gene; Int = integrase Intl1.

SOURCE: Patrice Courvalin, Institut Pasteur, Paris, France.

From: 4, Antibiotic Resistance: Origins and Countermeasures

Cover of Microbial Evolution and Co-Adaptation
Microbial Evolution and Co-Adaptation: A Tribute to the Life and Scientific Legacies of Joshua Lederberg: Workshop Summary.
Institute of Medicine (US) Forum on Microbial Threats.
Washington (DC): National Academies Press (US); 2009.
Copyright © 2009, National Academy of Sciences.

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