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Institute of Medicine (US) Forum on Microbial Threats. Microbial Evolution and Co-Adaptation: A Tribute to the Life and Scientific Legacies of Joshua Lederberg: Workshop Summary. Washington (DC): National Academies Press (US); 2009.

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Microbial Evolution and Co-Adaptation: A Tribute to the Life and Scientific Legacies of Joshua Lederberg: Workshop Summary.

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Microbial Evolution and Co-Adaptation: A Workshop in Honor of Joshua Lederberg

May 20–21, 2008

The National Academies

500 Fifth Street, NW—Room 100

Washington, DC

DAY 1: MAY 20, 2008

9:00–9:30:Registration and continental breakfast
9:30–9:45:Welcoming remarks
 Forum Leadership
9:45–10:45:Reflections on the life and scientific legacies of Josh Lederberg

Moderator: Margaret “Peggy” Hamburg, M.D., Nuclear Threat Initiative

  • David A. Hamburg, M.D.
    Carnegie Corporation
  • Stephen S. Morse, Ph.D.
    Columbia University
10:45–11:15:Questions from Forum members and audience
11:30–12:30:Lunch and continuation of Day 1 morning discussion

Session I The Microbiome and Co-Evolution

Moderator: Jo Handelsman, Ph.D., University of Wisconsin, Madison

12:30–1:00:Evolutionary and ecological processes that shape natural microbial communities
 Jill Banfield, Ph.D.
 University of California, Berkeley
1:00–1:30:Plant-microbe symbioses: the good, the bad, and the cheater!
 Jean-Michel Ané, Ph.D.
 University of Wisconsin, Madison
1:30–2:00:The experimental deciphering of the complex molecular dialogue between host and bacterial symbiont
 Margaret McFall-Ngai, Ph.D.
 University of Wisconsin, Madison
2:00–2:30: War and peace: humans and their microbiome
 David Relman, M.D.
 Stanford University
2:30–3:15:Questions from Forum members and audience

Session II Microbial Evolution and the Emergence of Virulence

Moderator: P. Frederick Sparling, Ph.D., University of North Carolina, Chapel Hill

3:30–4:00:A schizophrenic view of bacterial pathogenicity
 Stanley Falkow, Ph.D.
 Stanford University
4:00–4:30:Recent evolution in invasive salmonellosis
 Gordon Dougan, Ph.D.
 The Sanger Institute
4:30–5:00:Whole genome analysis of pathogen evolution
 Julian Parkhill, Ph.D.
 The Sanger Institute
5:00–5:30:The evolution of virulence in bacteria and viruses: an opinionated rant
 Bruce Levin, Ph.D.
 Emory University
5:30–6:00:Questions from Forum members and audience
6:15:Adjourn—Day 1
7:00–9:00:Dinner with speakers and Forum members and continuing discussion of Day 1

DAY 2: MAY 21, 2008

8:30–9:00:Continental breakfast
9:00–9:15:Summary of Day 1
 David Relman, M.D.
 Chair, Forum on Microbial Threats
9:15–9:45:Further reflections on Josh Lederberg’s life and legacies
 Adel Mahmoud, M.D., Ph.D.
 Princeton University

Session III Mechanisms of Resistance

Moderator: Steven Brickner, Ph.D., Pfizer, Inc.

9:45–10:15:Microbial drug resistance: an old problem that requires new solutions
 Stanley N. Cohen, M.D.
 Stanford University
10:15–10:45:Antibiotic resistance and the future of antibiotics
 Julian Davies, Ph.D.
 University of British Columbia
11:00–11:30:Expanding the resistance universe with metagenomics
 Jo Handelsman, Ph.D.
 University of Wisconsin, Madison
11:30–12:15:Questions from Forum members and audience
12:15–1:00:Lunch and continuation of Day 2 morning discussion

Session IV Anticipation of Future Emerging Infectious Diseases—Is the Past, Prologue?

Moderator: Stanley Lemon, M.D., University of Texas, Galveston

1:00–1:30:Emerging infections: condemned to repeat?
 Stephen S. Morse, Ph.D.
 Columbia University
1:30–2:00:Can we predict future trends in disease emergence?
 Peter Daszak, Ph.D.
 Consortium for Conservation Medicine, Wildlife Trust
2:00–2:30:Pathogen emergence: ecology or evolution?
 Mark Woolhouse, Ph.D.
 University of Edinburgh
2:30–3:00:Genomic evolvability and the origin of novelty
 Jonathan Eisen, Ph.D.
 University of California, Davis
3:00–3:30:Questions from Forum members and audience
3:30–4:00:Open discussion and wrap-up
Copyright © 2009, National Academy of Sciences.
Bookshelf ID: NBK45708


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