TABLE 3-23Studies of DBP and Hypospadias in Rats

StudyAnimal GroupLife Stage ExposedObservation TimeNOAEL (mg/kg-day)LOAEL (mg/kg-day)
Barlow et al. 2004Sprague-Dawley ratGD 12-21PND 180100500
Drake et al. 2009Wistar ratGD 13.5-21.5>12 weeks100500
Jiang et al. 2007Sprague-Dawley ratGD 14-18PND 1250500
Kim et al. 2010Sprague-Dawley ratGD 10-19PND 11500700
N. Li et al. 2015Wistar ratGD 12.5-20.5PND 63100300
Mylchreest et al. 1998Sprague-Dawley ratGD 3 to PND 20GD 100250500
Mylchreest et al. 1999Sprague-Dawley ratGD 12-21PND 100-105250500
Mylchreest et al. 2000Sprague-Dawley ratGD 12-21PND 110-120100500
*

Indicates that testes testosterone production was measured.

NOTES: The earliest life stage evaluated is shown when multiple observation times were assessed. GD, gestation day; LOAEL, lowest-observed-adverse-effect level; NOAEL, no-observed-adverse-effect level; PND, postnatal day.

From: 3, Phthalates and Male Reproductive-Tract Development

Cover of Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals
Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals.
National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee on Endocrine-Related Low-Dose Toxicity.
Washington (DC): National Academies Press (US); 2017 Jul 18.
Copyright 2017 by the National Academy of Sciences. All rights reserved.

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