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Nutrition
Nearly half of the world’s adult population is either clinically obese or overweight. Excess weight increases risk for multiple other chronic diseases and represents a major global health issue. Weight gain results from an imbalance between energy intake and expenditure, which can only be corrected if the physiologic and neuroendocrine systems that have the potential to control energy balance are identified.
The first edition of this book reviewed knowledge on the intake of microand macronutrients, food choice, and opposing views on whether or not there are mechanisms that control food intake. Appetite and Food Intake: Central Control, Second Edition contains all new chapters and serves as a companion to the first by reviewing current knowledge on neuroendocrine mechanisms that influence food intake and glucose metabolism, including environmental influences on their development, with an emphasis on recent progress in understanding forebrain and hindbrain control of ingestive behavior.
Features
- Provides overview of the importance of hindbrain in control of energy intake and glucose metabolism
- Identifies contributions made by new technologies to understanding central control of food intake
- Discusses advantages of novel models for studying ingestive behavior
- Presents current knowledge on environmental factors that influence development of neural circuits controlling energy balance
- Reviews current weight control drugs and current thinking on which aspect of body composition is controlled
In addition, there is a discussion on the benefits derived from novel models for exploring ingestive behavior and the progress that has been achieved due to new technologies. Although major progress is being made in understanding the complex interplay between different control systems, the limits of our knowledge are acknowledged in chapters that review the efficacy of current weight control drugs and the relative importance of fat free mass and body fat in driving food intake.
Contents
- Preface
- Contributors
- 1.
Appetite Control in C. elegans
Kristen Davis, Mi Cheong Cheong, Ji Su Park, and Young-Jai You.
- 2.
Central and Peripheral Regulation of Appetite and Food Intake in Drosophila
Audrey Branch and Ping Shen.
- 3. The Hamster as a Model for Human Ingestive BehaviorRuth B.S. Harris.
- 4. Beyond Homeostasis: Understanding the Impact of Psychosocial Factors on Appetite Using Nonhuman Primate ModelsMark E. Wilson and Vasiliki Michopoulos.
- 4.1. Introduction
- 4.2. Living in an Obesogenic Environment
- 4.3. Adverse Social Experience and Feeding Behavior
- 4.4. Estradiol and Diet Interact with Stress History to Shape Feeding Behavior
- 4.5. Signals Sustaining Emotional Feeding
- 4.6. Targets of Stress Signals Mediating Emotional Feeding
- 4.7. Missing Pieces Using Nonhuman Primate Models
- 4.8. Conclusion
- Acknowledgments
- Literature Cited
- 5. Untangling Appetite Circuits with Optogenetics and ChemogeneticsMichael J. Krashes.
- 5.1. Background
- 5.2. Introduction to Chemogenetic and Optogenetic Strategies
- 5.3. An Entry Point into Feeding Circuitry—ARCAgRP Neurons
- 5.4. Novel PBN Circuits Underlying Feeding
- 5.5. ARCAgRP Neural Plasticity
- 5.6. Intrahypothalamic and Extrahypothalamic Neural Modulation of Appetite
- 5.7. Conclusions
- Literature Cited
- 6. The Use of Functional Magnetic Resonance Imaging in the Study of Appetite and ObesitySelin Neseliler, Jung-Eun Han, and Alain Dagher.
- 7. Development of Hypothalamic Circuits That Control Food Intake and Energy BalanceSebastien G. Bouret.
- 8. Maternal and Epigenetic Factors That Influence Food Intake and Energy Balance in OffspringLin Song, Miranda D. Johnson, and Kellie L.K. Tamashiro.
- 9. Monitoring and Maintenance of Brain Glucose Supply: Importance of Hindbrain Catecholamine Neurons in This Multifaceted TaskSue Ritter.
- 9.1. Importance of Glucose Monitoring for Normal Brain Function
- 9.2. Glucose-Sensing Mechanisms
- 9.3. Peripheral Responses to Glucose Deficit
- 9.4. Central Responses to Glucose Deficit
- 9.5. Importance of Hindbrain Catecholamine Neurons in Systemic Glucoregulation
- 9.6. Interaction of CA Neurons with Forebrain Neurons
- 9.7. Challenges for Future Research
- Literature Cited
- 10. Hindbrain Astrocyte Glucodetectors and CounterregulationRichard C. Rogers, David H. McDougal, and Gerlinda E. Hermann.
- 11. Vagal Afferent Signaling and the Integration of Direct and Indirect Controls of Food IntakeRobert C. Ritter, Carlos A. Campos, Jason Nasse, and James H. Peters.
- 11.1. Integration of Sensory Information—The Foundation for Control of Food Intake
- 11.2. Leptin Acts on the Vagus to Modulate Direct Controls of Food Intake
- 11.3. Mechanisms for Integration of Direct and Indirect Controls of Feeding in the Hindbrain
- 11.4. Vagal Afferent Modulation and the Sensory Experience of Satiation
- Literature Cited
- 12. Energy Metabolism and Appetite Control: Separate Roles for Fat-Free Mass and Fat Mass in the Control of Food Intake in HumansMark Hopkins and John E. Blundell.
- 12.1. Introduction
- 12.2. Comment on the Lipostatic Theory of Appetite Control
- 12.3. Energy Expenditure and Energy intake
- 12.4. Role of Energy Expenditure and Body Composition in the Control of Food Intake
- 12.5. Fat free mass as an Orexigenic Driver
- 12.6. Resting Metabolic Rate and Total Daily Energy Expenditure as Drivers of Food Intake
- 12.7. Implications for the Control of Appetite
- 12.8. Summary
- Conflict of Interest
- Funding
- Literature Cited
- 13. Pharmacotherapy for Weight LossThomas A. Lutz and Lori Asarian.
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Version Date: 20161124
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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe.
Names: Harris, Ruth B. S.
Title: Appetite and food intake : central control / [edited by] Ruth B.S. Harris.
Description: Second edition. | Boca Raton : CRC Press, 2017. | Previous edition:
Appetite and food intake : behavioral and physiological considerations / edited by Ruth B.S. Harris, Richard D. Mattes (Boca Raton : CRC Press, 2008). | Includes bibliographical references.
Identifiers: LCCN 2016045823 | ISBN 9781498723169 (hardback : alk. paper)
Subjects: LCSH: Ingestion--Regulation. | Appetite--Physiological aspects. | Appetite disorders. | Food habits--Psychological aspects.
Classification: LCC QP147 .A66 2017 | DDC 612.3/1--dc23
LC record available at https://lccn.loc.gov/2016045823
T&F Books
- NLM CatalogRelated NLM Catalog Entries
- Review Control of food intake in the obese.[Obes Res. 2001]Review Control of food intake in the obese.Blundell JE, Gillett A. Obes Res. 2001 Nov; 9 Suppl 4:263S-270S.
- The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?[Physiol Behav. 2015]The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?Blundell JE, Finlayson G, Gibbons C, Caudwell P, Hopkins M. Physiol Behav. 2015 Dec 1; 152(Pt B):473-8. Epub 2015 May 31.
- Neuroendocrine regulation of food intake.[Curr Opin Gastroenterol. 2008]Neuroendocrine regulation of food intake.Chaptini L, Peikin S. Curr Opin Gastroenterol. 2008 Mar; 24(2):223-9.
- Review Hypothalamic Fatty Acid Sensing in the Normal and Disease States.[Fat Detection: Taste, Texture,...]Review Hypothalamic Fatty Acid Sensing in the Normal and Disease States.Chari M, Lam CKL, Lam TKT. Fat Detection: Taste, Texture, and Post Ingestive Effects. 2010
- Guest editor's introduction: Energy homeostasis in context.[Horm Behav. 2014]Guest editor's introduction: Energy homeostasis in context.Schneider JE. Horm Behav. 2014 Jun; 66(1):1-6. Epub 2014 May 9.
- Appetite and Food IntakeAppetite and Food Intake
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