Table 10IMRT vs. 3DCRT: Summary of study design, quality, and key outcomes

SiteStudiesnRCTProspective ObservationalAssessor BlindedGroups ComparableTreatments in same time periodWell-done multi- variable analysis/intention- to-treatUSPSTF Good/Fair
NPC22880101100/0
OPH44101101210/0
PNS1680000000/0
UNP000000000/0
LAR000000000/0
MIX79860500300/0
Total1417521702610/0
OutcomeTotal No. studiesLarge (>15 pctg pts) IMRT-3DCRT differenceModerate (6–15 pctg pts) IMRT-3DCRT differenceSmall (0–5 pctg pts) IMRT-3DCRT differenceUnquantifiable IMRT-3DCRT difference
No. StudiesSigNSp NRNo. StudiesSigNSp NRNo. StudiesSigNSP NRNo. StudiesSigNSp NR
Acute xerostomia422+21?1+
Late xerostomia744+22+11+
Acute mucositis611+11+43+1−
Late mucositis211−11+
Acute dysphagia211+11?
Late dysphagia221−1−
Acute skin toxicity522+11−21−
1?
Late skin toxicity311+22+
Acute osteoradionecrosis/bone toxicity0
Late osteoradionecrosis/bone toxicity211+11−
Tumor control*822+22+53+
1?
1−
Patient survival*811+41+1+
1−
1+43+
1?

+: favors IMRT; −: favors 3DCRT; ?: unclear which group is favored;

*

Columns to the right may not sum to the total, because some studies reported more than one outcome for tumor control or patient survival, e.g., disease-specific survival and overall survival.

Abbreviations: NR: not reported; NS: not significant; pctg: percentage; pts: patients; RCT: randomized, controlled trial; sig: significant; USPSTF: U.S. Preventive Services Task force;

From: Results

Cover of Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer [Internet].
Comparative Effectiveness Reviews, No. 20.
Samson DJ, Ratko TA, Rothenberg BM, et al.

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