Table 213DCRT vs. 2DRT: Cancer of the nasal cavity/paranasal sinuses, mixed settings

StudySettingOutcomenUnivariate p valueMultivariable p valueStudy designInitial groups comparable?Treatments in same time period?Well-done multivariable analysis?Study quality rating
Dirix et al. 2007[68]Primary/preoperative/postoperative RTXerostomia127Permanent, Δ−20, .08RetrospectiveUnclearNoNot donePoor
Dirix et al. 2007[68]Mucositis127Late, Δ?, NSNot done
Chen et al. 2007[67]Primary/preoperative/postoperative RT ± post-RT/concurrent chemotherapyMucositis104Late, ≥ Gr 3, Δ−1, p NRRetrospectiveUnclearNoNot donePoor
Chen et al. 2007[67]Skin toxicity104Late, ≥ Gr 3, Δ−8, p NRNot done
Dirix et al. 2007[68]Osteoradionecrosis/bone toxicity127Late, ungraded, Δ=0, p NRNot done
Chen et al. 2007[67]Osteoradionecrosis/bone toxicity104Late, ≥ Gr 3, Δ+1, p NRNot done
Dirix et al. 2007[68]Local control127NSNo
Chen et al. 2007[67]Local control1045 yr., Δ+3, NSNot done
Dirix et al. 2007[68]Disease-free survival127NSNo
Chen et al. 2007[67]Disease-free survival104NSNot done
Dirix et al. 2007[68]Disease-specific survival127NSNo
Dirix et al. 2007[68]Overall survival127NSNo
Chen et al. 2007[67]Overall survival1045 yr., Δ+6, NSNot done

Abbreviations: Δ: change; Gr: grade; NR: not reported; NS: not significant; RT: radiotherapy; yr: year;

From: Results

Cover of Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer [Internet].
Comparative Effectiveness Reviews, No. 20.
Samson DJ, Ratko TA, Rothenberg BM, et al.

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