FIGURE 4-4. Brain Dynamics and Memory.

FIGURE 4-4Brain Dynamics and Memory

Multistability in cortical networks has been proposed as a mechanism for spatial working memory. The top panel of the figure shows the spatiotemporal map of action potential firing rate in a computational model of monkey prefrontal cortex. The model network is presented with a cue at a 180-degree angle at time C and retains a memory in the form of a stable “bump” state during a delay period D until the memory is recalled at time R. The action potential firing pattern and spike rate histogram of an individual model neuron in the network (bottom right) closely resemble those of a cortical neuron in a monkey performing a cue-delay-recall task (bottom left). Action potential firing patterns in the bottom plots are represented as rastergrams, where each line shows the activity recorded during one experimental trial and each action potential is represented by a tick mark. SOURCE: Compte et al., 2000, reprinted with the permission of Oxford University Press.

From: 4, Common Themes at the Intersection of Biological and Physical Sciences

Cover of Research at the Intersection of the Physical and Life Sciences
Research at the Intersection of the Physical and Life Sciences.
National Research Council (US) Committee on Research at the Intersection of the Physical and Life Sciences.
Washington (DC): National Academies Press (US); 2010.
Copyright © 2010, National Academy of Sciences.

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