Figure 3. Pathway of ISGylation.

Figure 3

Pathway of ISGylation. ISG15, a ubiquitin-like molecule containing 2 conserved ubiquitin domains, is conjugated to proteins; this conjugation is similar to ubiquitination. In this system, the E1 (UBE1L), E2 (UbcH8) and E3 (Efp and Herc5) enzymes required for ISGylation have been hitherto identified.

From: TRIM PROTEINS AS RING FINGER E3 UBIQUITIN LIGASES

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